Heart transplantation in systemic (AL) amyloidosis: A retrospective study of eight French patients (original) (raw)

2008, Archives of Cardiovascular Diseases

Background.-Immunoglobulinic (AL) amyloidosis is a complication of plasma cell dyscrasia, characterized by widespread deposition of amyloid fibrils derived from monoclonal light chains. Cardiac amyloid is the main prognostic factor, with a median survival of six months. Cardiac transplantation in AL amyloidosis is associated with high mortality, due to disease recurrence in the allograft and systemic progression. Suppression of light chain (LC) production

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