Association between duration of endogenous estrogen exposure and cardiovascular outcomes: A population – based cohort study (original) (raw)

Duration of endogenous estrogen exposure is apparently associated with risk of cardiovascular disease, the longer durations being more cardiovascular disease protective in women. We aimed to investigate the association of cumulative duration of endogenous estrogen exposure over women's reproductive lifespans with cardiovascular disease outcomes. Main methods For the purpose of the present study, of 10192 female participants, after excluding those using HRT (n=84), 3656 women, aged ≥ 30 years, who met eligibility criteria were selected and divided into three groups based on tertiles (T1,T2,T3) of exposure durations to endogenous estrogen. Cox proportional hazards regression model was used to estimate associations between exposure durations and cardiovascular disease outcomes. Key findings Cardiovascular events occurred in 352 participants over a median follow-up of 14.2(13.5, 14.6) years (7.7 per 1000 person years; 95%

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