A study of comparing single dose granisetron with combination of granisetron with dexamethasone in preventing postoperative nausea vomiting in laparoscopic cholecystectomies (original) (raw)
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Journal of Evolution of medical and Dental Sciences, 2015
OBJECTIVE: To compare the efficacy and safety of Granisetron versus Ondansetron in prevention of post-operative nausea and vomiting in patients undergoing elective Laparoscopic Cholecystectomy under general anaesthesia. MATERIALS AND METHODS: After the approval from IEC, the study was started and conducted over a period of two years i.e., from 2010-2012. Data was collected from 100 ASA I and II patients scheduled for laparoscopic cholecystectomy aged between 20-60 years at Government General Hospital, Kakinada. Both the study groups were selected from these patients. Written informed consent was taken from all patients. Preanesthetic medication was given with Ranitidine 150mg and Lorazepam 1mg, the night before and morning of surgery. Patients were randomly allocated into 2 groups. Group A Received Inj. Ondansetron 8mg diluted in 5ml of normal saline. Group B Received Inj. Granisetron 1mg diluted in 5ml of normal saline. INJ. Glycopyrolate 0.01mg/kg & INJ. Fentanyl (1-2μ/Kg) given i...
2016
Postoperative nausea and vomiting (PONV) after laproscopic cholecystectomy remains a common problem in spite of introduction of newer antiemetics with better efficacy and safety profiles. None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade on a particular type of receptor. The addition of adjuvants like dexamethasone and promethazine to antiemetics like granisetron can improve the outcome. However, lack of knowledge limits its acceptance. The aim of the present study was to compare the effects of dexamethasone and promethazine as adjuvant to granisetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. In Method 120 patients, aged 25-55 years, scheduled for elective cholecystectomy were enrolled in a randomized, double blinded manner and assigned to one of three treatment regimens: granisetron 2mg + 5ml normal saline (Group I), granisetron 2mg + dexamethasone 8mg (Group ...
Surgical Endoscopy, 2008
Background Laparoscopic cholecystectomies are associated with an appreciably high rate of postoperative nausea and vomiting (PONV). This study was designed to compare the effectiveness of ondansetron, granisetron, and dexamethasone for the prevention of PONV in patients after laparoscopic cholecystectomy. Methods A total of 80 American Society of Anesthesiologists (ASA) physical class I-II patients scheduled for laparoscopic cholecystectomy were included in this randomized, double blind, placebo-controlled study. All patients received a similar standardized anesthesia and operative treatment. Patients were randomly divided into four groups (n = 20 each). Group 1, consisting of control patients, received 0.9% NaCl; group 2 patients received ondansetron 4 mg i.v.; group 3 patients received granisetron 3 mg i.v.; and group 4 patients received dexamethasone 8 mg i.v., all before the induction of anesthesia. Both nausea and vomiting were assessed during the first 24 h after the procedure. Results The total incidence of PONV was 75% with placebo, 35% with ondansetron, 30% with granisetron, and 25% with dexamethasone. The incidence of PONV was significantly less frequent in groups receiving antiemetics (p \ 0.05). The differences between dexamethasone, granisetron, and ondansetron were not significant. Conclusions Prophylactic dexamethasone 8 mg i.v. significantly reduced the incidence of PONV in patients undergoing laparoscopic cholecystectomy. Dexamethasone 8 mg was as effective as ondansetron 4 mg and granisetron 3 mg, and it was more effective than placebo.
IOSR Journal of Dental and Medical Sciences, 2013
Post operative nausea and vomiting (PONV) continue to be frequent occurrences, even when conventional antiemetics are prophylactically used. In a randomized double blind study, 100 female patients scheduled for elective laparoscopic cholecystectomy under general anaesthesia were divided into 2 groups of 50 patients each and received 0.1mg/Kg of Ondansetron (Group X) or 0.04mg/Kg of Granisetron (Group Y) preoperatively. Patients were observed for 24 hours post operatively and interpretation of symptoms of nausea and vomiting was done according to Gan and Alexander scale (0-2). 80% of patients in Group Y and 48 % patients in Group X did not experience PONV; the difference was statistically significant (p<0.001). 2 patients (4%) in Group Y and 15patients (30%) in Group X required rescue antiemetic medication during the 24 hour study period. The difference was found to be highly significant (p<0.001) The difference in the incidence of PONV between the two groups after 6 hours to 24 hours was highly significant (p<0.001). It was concluded that prophylactic administration of Granisetron is more effective than Ondansetron, in reducing in incidence of PONV with prolonged effects.
Scholars Journal of Applied Medical Sciences, 2020
Original Research Article Objective: In this study our main goal is to comparison of the effectiveness of metoclopramide combined with dexamethasone and granisetron alone in preventing post-operative nausea and vomiting in high risk patients undergoing laparoscopic cholecystectomy. Method: It is a cross sectional observational study on 120 patients who underwent laparoscopic cholecystectomy. The study period was July, 2017 to June, 2018. The study was conducted in the department of Anesthesia, Analgesia and Intensive care medicine of BSMMU. All the patients were chosen by purposive sampling. The study population was divided into two groups by simple lottery method. Group A patients got Granisetron (1mg iv single dose) and Group B patients got Metoclopramide and Dexamethason (Inj. Metoclopramide (10mg) and Inj. Dexamethasone (8mg)) just before induction. The observations were plotted into tabular and figure form. The categorical variable was analyzed by chi square test and the quantitative variables were analyzed by unpaired student's t test. Results: The mean age of Group A and B patients were 33.73±6.97 and 34.62±7.16 years respectively. The sex ratio showed 21:39 and 15:45 in case of Male: Female respectively.out of 60 patients in each group PONV was reported in 20 (33.33%) and 16(26.67%) patients in Group A and Group B respectively. No PONV was reported in 40 (66.67%) and 44 (73.33%) patients in Group A and B respectively. 40(66.67%) and 44(73.33%) in Group A and B respectively showed no nausea and vomiting. 8(13.33%) and 7(11.67%) patients showed score 1 (nausea) in Group A and B respectively. On the contrary, 7(11.67%) and 5(8.33%) patients in Group-A and B respectively were categorized PONV score 2 (who experienced both nausea and vomiting. Only 5(8.33%) and 4(6.67%) patients experienced repeated vomiting ≥2 times who were categorized as PONV score 3.(p= 0.872). Among rescue antiemetic drug, analgesic drug use and postoperative hospital stay nothing but the hospital stay showed the statistically significant difference between the groups (P=0.000044). Conclusion: From our results we can conclude that, no statistically significant difference was observed between metoclopramide combined with dexamethasone group and granisetron alone except the granisetron from the point of view of short hospital stay.
International Journal of Research in Medical Sciences, 2019
Background: In laparoscopic surgeries, insufflation with carbon dioxide triggers vagal afferents on the bowel and peritoneum which induces emesis by activating the vomiting center. It is hypothesized that combined antiemetics with different sites of activity would be more effective than one drug alone for the prophylaxis against PONV. So, the present study was planned to compare the efficacy of granisetron, dexamethasone and combination of granisetron with dexamethasone to prevent PONV.Methods: This randomized prospective double-blind study was performed on 120 patients, aged between 18 and 58 years of ASA physical status I and II of either sex undergoing laparoscopic surgeries under general anesthesia. Patients were randomized in three groups, group I (granisetrone 2 mg I.V.), group II (dexamethasone) 8 mg I.V., group III (granisetrone+dexamethasone) 2 mg+8 mg I.V. with 40 patients in each group. Complete response, incidence of nausea, vomiting, and rescue antiemetic were recorded ...
Journal of the Bangladesh Society of Anaesthesiologists, 2009
Postoperative nausea and vomiting are the common morbidity after general anaesthesia and surgery 1. One of the essential goals of anaesthetic management is to prevent postoperative nausea and vomiting. The consequence of prolonged postoperative nausea and vomiting (PONV) ranges from unexpected admission of day patients with its economic implications to physical, metabolic and psychological effects on the patients which slow their recovery and reduced their confidence in future surgery and anaesthesia 2. The present study was designed to compare the efficacy of Granisetron with that of Ondansetron and Metoclopramide in the treatment and prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. This study was also done to observe the incidence of nausea and vomiting in the postoperative period, to observe the requirement of rescue antiemetic, to find out the haemodynamic stability, saturation of arterial oxygen in these groups of subject and to detect the patients satisfaction by verbal rating scale after 24 hours of surgery. A total number of 90 patients, sex female, age range 30-50 years undergoing laparoscopic cholecystectomy were selected. They were equally divided into three groups of 30 patients. They received a standard general anaesthesia. Group I received injection Granisetron (1mg), Group II received injection Ondansetron (8mg), Group III received injection Metoclopramide (10mg) 10 minutes before reversal of anaesthesia. Postoperative analgesia was provided with injection pethidine (1.5mg/kg/bd.wt.) intramuscularly 8 hourly.
Birat Journal of Health Sciences
IntroductionLaparoscopic cholecystectomy has higher incidence of postoperative nausea and vomiting (PONV). In routine practice single dose of drug is given prophylactically during the surgery.ObjectiveThis study aimed to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 (5HT3) receptor antagonists, Ondansetron and Granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy.MethodologyIt was a randomized, single blind study, conducted in 75 patients undergoing laparoscopic cholecystectomy. Patients were divided into two groups: Group O and Group G. Patients in group O were given 0.1 mg/kg Ondansetron intravenously (IV) and patients in Group G were given 0.04 mg/kg Granisetron. The standard general anesthetic technique was administered to all the patients. Episodes of nausea, retching and vomiting were assessed during the first 24 hours after anesthesia. Collected data was applied with appropriate test in SPSS 16 and overall signif...
JNMA; journal of the Nepal Medical Association
Laparoscopic surgeries are known to be associated with a higher incidence of postoperative nausea and vomiting (PONV). Prophylaxis of PONV is usually achieved with a single-dose antiemetic drug administered during the surgical procedure. The aim of this study was to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 (5HT3) receptor antagonists, ondansetron and granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy. It was a randomized, double blind study, conducted in 90 patients. Patients were divided into two groups: Group A and Group B with 45 patients in each group. Patients in groupA were given 100 microgram/kg ondansetron intravenously (IV), and patients in Group B were given 40 microgram/kg granisetron. Both the drugs were diluted in 10 ml of 0.9% NaCl and were given at the end of surgery. The standard general anesthetic technique was administered to all the patients. Episodes of nausea, retching and vomiting were asses...