Haematological changes associated with typhoid fever (original) (raw)
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Haematological profile in typhoid fever
IP Innovative Publication Pvt.Ltd, 2017
Objective: 1. To determine haematological changes in typhoid fever. 2. To establish early diagnosis using haematological parameters for prompt treatment of the disease. Materials and Method: This study was conducted at Khaja Banda Nawaz Institute of Medical Sciences and Teaching Hospital Kalaburgi from March 2015 to May 2015. 130 patients with suspected typhoid fever were included in this study and were confirmed by Widal test. Complete blood count was carried out in all these patients. Results: A total of 130 cases of suspected typhoid fever were taken, out of which 58 (44.61%) were positive for typhoid fever and 72(55.38%) were negative. In majority of the positive cases, neutrophilia was seen in 23 cases (39.65%), anaemia in 20 cases (34.48%), leucocytosis in 13 cases (22.41%) and thrombocytopenia in 10 cases (17.24%). Conclusion: To conclude, usually anemia, neutropenia and thrombocytopenia are observed in typhoid fever but the present study demonstrated neutrophilia in patients who had complications like perforation, bronchopneumonia and urinary tract infection. Hence in patients with typhoid fever, neutrophilia indicates an evidence of complications.
2020
Background Typhoid or enteric fever is caused by Salmonella typhi. It is largely a disease of developing nations due to poor standard of hygiene and unavailability of potable water. The most prominent feature of the infection is fever which gradually rises to a high plateau. The prevalence of typhoid fever has been on the increase which is associated with several hematological parameters. Objectives This study was carried out to determine the changes in various hematological parameters in our study subjects. Method Four Hundred- (400) samples were obtained from volunteer subjects visiting the outpatient department of the Landmark University Medical Center. 200 typhoid positive samples were collected from subjects while 200 typhoid negative blood samples served as controls (From both male and female subjects each). Widal test was carried out as a confirmatory test for typhoid fever and evaluation of the hematological parameters were performed. The hematological parameters considered ...
Haematological Changes Associated with Male and Female Typhoid Fever Patients
This study was designed to determine the changes in packed cell volume (PCV), red blood cell count (RBC), haemoglobin content (HB), white blood cell count (WBC) and platelet (PLT) associated with typhoid fever male and female patients for its possible implication in anaemia, leucopenia, immune deficiency and thrombocytopenia. Twenty male and twenty female patients were divided into four experimental groups made up of ten typhoid positive males (TPM), ten typhoid negative male (TNM), ten typhoid positive female (TPF) and ten typhoid negative female (TNF). The haematological parameters were evaluated using sysmex KX-21N automated haematology analyzer. The result of the haematological changes associated with typhoid fever male patients showed no significant decrease (p < 0.05) in the mean values of white blood cell count of the typhoid positive male patients compared with the control, but there was significant decrease in the mean values of PCV, HB, RBC and PLT of the typhoid positive male patients compared to the control. Similarly the results for the female patients showed significant decrease in the mean values of PCV, HB, RBC, WBC and PLT of the typhoid positive female patients compared to the control. The result of the comparative hematological changes associated with typhoid fever male and female patients showed there was significant decrease in the mean values of PCV, HB, RBC and WBC of the typhoid positive female patients compared with the typhoid positive male patients and a significant decrease in platelet of typhoid positive males compared to typhoid positive females. This study has shown that typhoid fever decreased significantly all haematological parameters in male patients evaluated except WBC and all haematological parameters evaluated in female patients and comparatively it affected the females more than the males except for platelet which was affected more in males than females. The implication of the result is that typhoid fever could lead to anaemia and thrombocytopenia in males but wouldn't lead to leucopenia and immune deficiency. Likewise in females, typhoid fever can lead to anaemia, thrombocytopenia, immune deficiency and leucopenia. Except for platelet, typhoid fever affected females more than males. Further studies should be carried out to determine the nutritional status of the patients so that the result of this study can be pursued for its clinical relevance in the management of typhoid fever.
Introduction: The hematological and demographical changes due to multi-organ involvement in typhoid fever are not uncommon and they are also related with each other's. The objective of this study was to find out the frequency and brutality of the above changes in adult patients admitted to the hospital because of typhoid fever. Material & Methods: This was a cross sectional study conducted in the for a period of one year from July 2015 to June 2016. A total number of 100 children with typhoid fever were studied and diagnose were based on clinical features, Widal test and blood culture. Results: Out of 100 patients 60% were probable case and 40% were confirmed case of typhoid fever. Homogenous distribution of cases amongst the three age groups with a male to female ratio of 1.5:1. The gender distribution of the studied participant, where the 40% female and 60 % male were detected. Mostly (86%) of the children had abatement of fever < 5 days while 58.1% children achieved normal liver span between 3-5 days of treatment and mortality was 0%. Conclusion: The study concluded that clinical pattern of typhoid fever conforms well to that of known pattern of the disease in children. Blood culture profile shows widespread emergence of nalidixic acid related resistant strains and the sporadic occurrence of cephalosporin resistant strains of hematological chnages. However, the first line antibiotics such as chloramphenicol and cotrimoxazole still have a role to play in the treatment of typhoid.
Haematological alterations due to typhoid fever in mayiladuthurai area, Nagapattinam
Typhoid fever is an acute systemic disease caused by salmonella typhi and is a serious problem in developing countries. Typhoid is known to affect all systems of our body. The effect of typhoid fever (enteric fever) were studied on basic haematological parameter of patient WBC, RBC, SGOT, SGPT, Hb, Alkaline phosphates, Total bilirubin, platelets, PCV, Eosinophil, Neutrophils, Lymphocytes. The comprehensive study of 50 sample were collected from culturally confirmed salmonella patient and apparently healthy individuals were used as control. Results obtained show that there was a significant decreases in the PCV, Hb, WBC, Total protein, Platelets, and PCV in typhoid patients compared with healthy individuals. But there was a significant increase in SGOT and SGPT as against those of apparently healthy [control] individuals.
Different Diagnostic Procedure of Typhoid Fever: A Review Update
Journal of Current and Advance Medical Research, 2014
Typhoid fever is diagnosed by using a combination of the clinical presentation, the isolation of Salmonella typhi from body fluids and by Widal test. In the first week of illness, the diagnosis may be more difficult because in this invasive stage with bacteraemia; the symptoms are those of generalized infections without localizing feature. Cultures of stool, urine, rose spots, bone marrow, gastric and intestinal secretions can all be useful for diagnosis. The efficacy of culture varies with the specimen being tested. In addition, the prehospital antibiotic therapy frequently used in developing countries complicates the isolation of infectious agents from clinical specimens especially from blood. Bone marrow appears to be the most suitable specimen because bone marrow culture has a higher sensitivity than blood culture. The methods of bacterial isolation are inherently slow and take more than 48 hours. That is why, serologic analysis becomes more important. The Widal test has got lim...
Histopathological and Haematological Manifestations of Typhoid Fever in Pediatric Age Group
Pakistan Journal of Medical and Health Sciences, 2022
Background: Typhoid fever is an acute systemic infection caused by Salmonella Enterica Serovar Typhi. Organism is transmitted by fecal-oral route. Aim: To determine frequency of various histopathological & hematological manifestations of typhoid fever in pediatric age group. Study design: Cross-sectional survey. Methodology: Complete blood count, pro-thrombin time and activated partial thromboplastin time were performed on the patients (n=140) to find out various hematological manifestations. Histopathological findings of patients undergoing colonoscopy and biopsy due to gastrointestinal presentations were also noted. Results: Present study had 65% males with 35% females. Almost 65.7% cases presented with anemia. Around 50.7% patients had leucopenia while eosinopenia was 67.1%. Cases (39.3%) presented with prolonged activated partial thromboplastin time while 32.1% cases had prolonged pro-thrombin time. Among histopathological manifestation, 3(2.14%) presented with Typhoid colitis/e...
Leukocyte counts of typhoid fever patients in Kano, Nigeria
niseb.org
The leukocyte counts of 73 patients with proven cases of typhoid fever were compared with that of 80 healthy individuals and 68 non-typhoid febrile patients in order to determine the diagnostic value of the leucocyte counts for typhoid fever. The mean total white blood count (WBC) of 5.9 ± 4.3 10 9 /l; differential neutrophil count of 65 ± 13.3% and lymphocyte counts of 34.17 ± 13% recorded in patients with typhoid infections were found to be significantly different (p < 0.05) from the corresponding counts obtained in healthy subjects. However, only the mean differential neutrophil and lymphocyte counts of these patients were found to have significant differences (p < 0.05) from those of the patients with other febrile illnesses. The mean total WBC showed no statistical difference (p > 0.05). These findings suggest that typhoid fever in adult in Kano is characterized by normal leukocyte count and relative neutrophilia.
The study was conducted to estimate the incidence of typhoid fever among patients attending Aminu Kano Teaching Hospital (AKTH) Laboratory, Kano, Nigeria, in the month of October, 2011. 115 Patients blood sample from various units of the Hospital where used. These units include GOPD, D/care, POPD, A/E etc. The Serum Were prepared from the blood samples and widal test was carried out using slide screen method for the detection of agglutination in serum samples. The results obtained are; (87 %) are positive to typhoid fever infection, (13%) are negative. Statistical analysis has shown that there was no significant difference between females and males typhoid fever positive on the bases of sex distribution of the patients attending Aminu Kano Teaching Hospital laboratory, for typhoid fever diagnosis in October, 2011.
International Journal of Medical and Biomedical Studies
India has a very high disease burden (214.2 per 1,00,000 individuals/year), primarily affecting children 5 to 15 years. Recently, there have been concerns of increasing proportion of infections in very young children, rising paratyphoid infections, and emerging drug resistance. Also, there are challenges in diagnosis and management of enteric fever due to lack of laboratory-based investigations. While blood culture remains the gold standard of diagnosis, the mainstays in developing countries are serological tests, which are suboptimal due to lack of standardization and uniformity. Hence based on above condition the present study was planned for Assessment of Clinical and Laboratory Parameters in Typhoid Fever in Pediatric Cases Admitted to NMCH, Patna. The present study was planned in Department of Pediatrics, Nalanda Medical College and Hospital, Patna, Bihar, India. The study was planned from January 2018 to November 2018. In the present study 50 childrens of age up to 18 years ha...