The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models (original) (raw)

The study investigates the role of plasmacytoid dendritic cells (pDCs) in humanized mouse models, particularly focusing on how the tumor microenvironment influences pDC infiltration and functionality. Using his-NOG-EXL mice, the research demonstrates that while pDC numbers are increased in peripheral blood, their functional presence, characterized by responsiveness to TLR7/8 agonists, is dependent on the specific tumor type. This highlights the importance of the tumor milieu in regulating pDC behavior and suggests potential therapeutic implications for cancer immunotherapy targeting pDCs.