Polyphenols-Loaded Sericin Self-Assembling Nanoparticles: A Slow-Release for Regeneration by Tissue-Resident Mesenchymal Stem/Stromal Cells (original) (raw)
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Materials (Basel, Switzerland), 2017
Some natural compounds have recently been widely employed in wound healing applications due to their biological properties. One such compound is sericin, which is produced by, while active polyphenols, polysaccharides and proteins are synthetized byandmicroalgae. Our hypothesis was that sericin, as an optimal bioactive polymeric carrier for microencapsulation process, could also improve the regenerative effect of the microalgae. A solvent-free extraction method and spray drying technique were combined to obtain five formulations, based on algal extracts (and, Chl and Art, respectively) or silk sericin (Ser) or their mixtures (Chl-Ser and Art-Ser). The spray drying was a suitable method to produce microspheres with similar dimensions, characterized by collapsed morphology with a rough surface. Art and Art-Ser showed higher antioxidant properties than other formulations. All microspheres resulted in cytocompatibility on fibroblasts until 1.25 mg/mL and promoted cell migration and the ...
polyphenols nanoencapsulation for therapeutic applications-2167-7956-1000139.pdf
Natural polyphenols are valuable compounds present in plants, fruits, legumes, chocolate, tea, wine and marine organisms possessing scavenging properties towards radical oxygen species. These abilities make polyphenols interesting either for the treatment of various diseases like inflammation and cancer or for anti-ageing purposes in cosmetic formulations. Unfortunately, such compounds lack in long-term stability, are very sensitive to light, and often present a low water solubility and poor bioavailability. To overcome these limitations and enhance polyphenols therapeutic applications, nanotechnology-based delivery systems have been developed, and among all, nanoencapsulation represented a promising strategy. This review described a recent overview of physicochemical nanoencapsulated polyphenols focusing on the most representative molecules such as resveratrol, quercetin, epigallocatechin-3-gallate, and curcumin.
Natural silk fibroin micro- and nanoparticles with potential uses in drug delivery systems
UPB Scientific Bulletin, Series B: Chemistry and Materials Science
Export Date: 29 April 2015, CODEN: SBPSF, Correspondence Address: Tudora, M.-R.; Department of Bioresources and Polymer Science, University POLITEHNICA of BucharestRomania; email: mihaelaramona.tudora@gmail.com, References: Vasil'Ev, A.E., Krasnyuk, I.I., Ravikumar, S., Tockmakhchi, V.N., Drug synthesis methods and manufacturing technology transdermal therapeutic systems for controlled drug release (a review) (2001) Pharmaceutical Chemistry Journal, 35 (1), pp. 613-626;