Histopathological Spectrum of Urinary Bladder Tumors: One Year Study in a Tertiary Health Care Centre (original) (raw)
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https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.6\_June2020/Abstract\_IJRR0021.html, 2020
Background: Urothelial carcinoma of urinary bladder cancer is the fourth most common cancer in men and eighth most common malignancy in women in the Western world. It is three times more common in men than in women and 90% of the bladder tumours are transitional cell carcinoma (TCC).Cystoscopic examination has a limited role in staging process for which transurethral resection (TURBT) of visible tumour down to the base is required which can accurately assess depth of tumour invasion. Design: This record based cross sectional study was carried out in the department of Pathology, Indira Gandhi Medical College, Shimla over a period of one year from January to December 2018. Data was collected from records using a structured clinical Performa which included various sociodemographic and clinical variables. WHO (2016)/ISUP classification was used to classify bladder tumours. Result and Discussion: The mean age of presentation was 60 years with male female ratio 3.8:1. Majority (94.5%) of the malignancies were papillary urothelial carcinoma with equal proportion of high and low grade. Muscle invasion was significantly higher in high grade (78%) as compared to low grade papillary urothelial carcinoma (1.6%). These parameters were comparable to other studies. Conclusion: Among Urothelial tumours the most common bladder tumours, primary epithelial malignancies are more common. High grade urothelial carcinomas are usually associated with muscle invasion supporting correlation of histologic grade with aggressiveness. These findings were also seen in various other studies in literature.
PARIPEX INDIAN JOURNAL OF RESEARCH, 2023
BACKGROUND:-Urinary bladder carcinoma is well known to show many histological divergent differentiation. The histological variants have important diagnostic, prognostic and therapeutic implications. The aim of the study was to find the prevalence of urothelial carcinoma in a tertiary care centre and to find the proportion of different histological grades and types of urothelial carcinoma. A retrospective monocentric study was done MATERIAL AND METHODS:between April 2020 and April 2022 which includes 37 bladder biopsies which were received in the histopathology section of the Department of Pathology, Gajra raja medical college. Patients who refuse to give consent and those having cystitis were excluded from the study. Out of total 37 cases which were reviewed, the RESULTS AND OBSERVATIONS :mean age was 62 years, with a male predominance (M:F ratio-3.16). Out of 37 cases, there were 8 cases each of highgrade urothelial carcinoma(21.6 %), high grade urothelial carcinoma with invasion (21.6 %) and high grade papillary urothelial carcinoma with invasion (21.6 %). There were 4 cases of high grade urothelial carcinoma with invasion with squamous differentiation (10.8 %), one case each of recurrent high grade urothelial carcinoma with invasion (2.7 %), well differentiated invasive glandular adenocarcinoma NOS (2.7%) and invasive micropapillary urothelial carcinoma with squamous differentiation (2.7 %), two cases each of low grade urothelial carcinoma-2 cases (5.4 %), low grade papillary urothelial carcinoma (5.4%) and papillary urothelial neoplasm of low malignant potential (PUNLMP) (5.4 %). CONCLUSION Urinary bladder carcinoma is more common in male than females. Average age of presentation is 62 years in present study. High grade urothelial carcinoma (83.8 %) is more common compared to low grade (10.8%). H&E staining with ancillary techniques like immunohistochemistry or molecular it can be very effective in to analyse histological variants to better understand this invasive disease hence aiding in further management of patients.
Urinary Bladder Cancer-Epidemiological and Histopathological Study
INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS, 2023
Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). To investigate the epidemiological and histopathological aspects in Libyan patients suffering from urinary bladder cancer, we performed a study on 39 bladder cancer biopsies from transurethral resection of bladder tumor (TURBT) and cystoscopic samples obtained from Oncology Department
Histopathological Gamut of Urinary Bladder Tumors: An Institutional Study
Introduction: The present study was taken up to assess the incidence of different histological variants of bladder tumors, site, age and sex distribution, presenting symptoms and a brief comparison was done about the histopathological features of the tumors occurring in young and old individuals. Material and methods: The present study is a retrospective two year descriptive study conducted in the Department of Pathology, tertiary care hospital in Guntur. The biological materials included in the study were Trans-urethral resection of bladder tumor (TURBT) specimens, complete and partial cystectomies. The formalin fixed specimens were routinely processed and haematoxylin and eosin stained slides were retrieved from the departmental archives and reviewed. Results: The most common location for bladder tumors in the present study was lateral wall constituting 40.9% of the cases followed by posterior wall (20.4%), trigone (13.6%), neck (11.3%), anterior wall (9.1%) and ureteric orifice (4.5%). Conclusion: To conclude, urothelial carcinomas are rare and prognostically better in the age group below 40 years, as most present with non invasive low grade papillary urothelial carcinomas.
British Biomedical Bulletin, 2014
Urinary bladder (or bladder) cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. A total of 355 cases of urinary bladder cancer were studied at the Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir, India over a period of 6 years (May 2006 to May 2012). Tumors were evaluated as per Age, Sex, smoking history, Histological type and grade of tumor. Males were more commonly affected than females. The commonest type of tumor observed was Transitional cell carcinoma (TCC) (98.5%), and peak age of incidence was 51- 60 years. In TCC 51.4% were low grade, 27.1% were papillomas and 21.4% were high grade. Smoking was found to be an important risk factor.
Urothelial tumors of the urinary bladder in Manipur: a histopathological perspective
Asian Pacific journal of cancer prevention : APJCP, 2012
To study the histomorphological pattern of urothelial tumors of the urinary bladder in Manipur and to evaluate whether any correlation exists between tumor grade and muscle invasion. A 10 year retrospective study of all consecutive cases diagnosed in the Department of Pathology RIMS - Imphal, between 1st January 2001 to 31st December 2010. The study included 26 cases of transitional cell tumors of urinary bladder. The male to female ratio was 1.5: 1 and the ages ranged from 38 years to 73 years (medians of 60 and 64 years, respectively). Of the total, 14 (53.9%) cases were low grade, 9 (34.6%) were high grade, 2 (7.7%) were papillomas and 1 (3.9%) was a papillary urothelial neoplasm of low malignant potential (PUNLMP). Pathological staging showed that 14 (53.9%) of the cases were stage PTa, four (15.4%) PT1, and eight (30.9%) PT2. Some 18.2% of low grade tumors and 75% of high grade tumors were invasive to the detrusor muscle layer. Bladder cancer is an uncommon disease, transitiona...
Urinary Bladder Tumors Clinical and Statistical Retrospective Study
Current Health Sciences Journal, 2018
Nowadays, urinary bladder cancer represents a major health problem, due to very high medical and social costs. This disease affects mainly the elderly. We performed a study on 1073 patients admitted to the Urology Clinic within the Emergency Clinical Hospital of Craiova, between 2013-2015 with bladder cancer. Of the 1073 cases, 741(69.06%) were diagnosed in men, and 332 (30.94%) were found in women, the men/ women ratio being of 2.23/1. The highest incidence of bladder tumors was recorded in individuals aged between 60 and 79 years old. In this age group, there were admitted 734 patients with bladder cancer, representing 68.44%. Regarding the tumor recurrence, out of 1073 bladder tumors, a number of 608 (56.66%) patients were diagnosed with primary tumors, while a number of 465 (43.34%) patients presented recurrent tumors. Of the symptoms presented by the patients, the most frequent were haematuria (present in about 87% of the patients), pollakiuria (present in 64% of the patients),...
International Urology and Nephrology, 2006
Bladder carcinoma is most common urological malignancy in Pakistan. The objective of the study was to determine the clinico-pathological characteristics of histologically confirmed bladder carcinoma at a tertiary care hospital of South Punjab, Pakistan. Methods: In two hundreds and twenty one patients (172 male and 49 female) bladder carcinoma was diagnosed from Jan 1998 to June 2005. All patients were evaluated with regards to clinical presentation, cystoscopic findings and histo-pathological data. Results: Male female ratio was 3.5:1. The median age was 58 years (range 18–87 years). 65% men had history of cigarette smoking while 51% women had long history of smokeless tobacco (nasal snuff or chewable) use. Most patients presented with painless hematuria. Primary transitional cell carcinoma was the most common (i.e. 96%) histological variety of bladder carcinoma. 63% patients had muscle invasive disease at the time of presentation. Even in superficial bladder carcinoma, most patients had invasion of lamina propria (pT1 disease). Conclusion: More than 90% of primary bladder carcinoma are of transitional cell variety and over 60% having muscle invasive disease at the time of diagnosis. Even in patients with superficial disease, majority (i.e. 98%) have invasion of lamina propria.
A gamut of Histopathological Lesions of Carcinoma of Urinary Bladder-A study of 43 cases
Aims/Objective: Urinary bladder cancer is the 7 th most common cancer seen worldwide, and is considerably more common in males than females worldwide. The present study was done to determine the age, sex incidence of the tumour occurrence and to study histopathological features of urinary bladder carcinoma with clinical background and to analyse the data descriptively. Materials and Methods: This prospective study was done with the biopsy and resected specimen of the urinary bladder carcinoma during a period of two years (October 2012-June 2014) from Yenepoya Medical College hospital, Mangalore. The specimens were received in 10% formalin and subjected to macroscopic description and appropriate relevant clinical details were noted. Standard tissue sections were given. Microscopic features were studied with H&E stained tissue sections using the parameters described in the proforma. Results: The present study was done on 43 cases of urinary bladder carcinomas. Cases occurred in age range of 42-91 years, peak incidence was seen in 6th decade of life, with a male to female ration of 3.1:1.No case was seen below 40 years of age. Haematuria was the most common presenting symptom, while lateral wall of urinary bladder was the commonest site of urinary bladder carcinoma with 58% of cases. Transitional cell carcinomas were the most common histological type found. 23 cases of non-invasive papillary urothelial carcinomas and 20 cases of invasive urothelial carcinomas were seen. Among non-invasive papillary urothelial carcinoma 15 cases were of low grade non-invasive carcinoma and 8 cases were of high grade non-invasive carcinoma. Conclusion: Urinary bladder carcinoma patients present in advanced stages with an overall poor survival. Incidence and prognosis can be improved by reduction of risk factors and early detection. Few of the most promising patient approaches for improving patient prognosis focus on techniques that allow early diagnosis in their early stages.