Multiorgan dysfunction due to colchicine (original) (raw)

Colchicine Toxicity: A Patient With Pneumopericardium

Colchicine is a highly active alkoloid with antiinflammatory properties. It is effective in gout, BehetÕs disease, familial Mediterranean fever, cirrhosisi and may be effective in scleroderma, sarcoidosis and skin disorders. Colchicine overdose is a rare but serious problem. Gastrointestinal distress is the earliest and most common manifestation and myelosuppression, cardiovascular collapse and respiratory failure are common life-threatenning side effects (1, 2). We report a patient with colchicine toxicity who developed pneumopericardium during his clinical course. Pneumopericardium has not been reported before and should be considered in the case of colchicine overdose.

Lethal Colchicine Intoxication Öldürücü Kolşisin Zehirlenmesi

2015

Colchicine is a well-recognized drug, that is used for the treatment of familial Mediterranean Fever, acute gout arthritis, amyloidosis and primary biliary cirrhosis. Colchicine is an alkaloid drug that is derived from Colchium autumnale.Diarrhea, sickness, vomiting, abdominal pain, excessive deficiency of electrolytes and fluid are common symptoms of intoxication due to higher absorption of colchicine from gastrointestinal surface. Colchicine has a narrow therapeutic index and suicide attempted with this drug has a higher mortality.Colchicine intoxication is a critical and life-threatening condition for patients so that pyhsicians should be aware of over dose and complications of this drug. Herein, we reported a case of colchicine overdose for suicide attempt.

Acute colchicine intoxication complicated with complete AV block

The Turkish journal of pediatrics

Colchicine, is an old and well-known drug, used for treatment of rheumatic diseases. Nausea, vomiting, abdominal pain, and diarrhea are the clinical symptoms of colchicine poisoning. Cardiotoxicity can lead to mortality. We report a case of colchicine intoxication complicated with complete heart block. A 9-year-old patient ingesting colchicine 0.4-0.5 mg/kg was transferred because of elevation of liver enzymes, and deterioration of kidney functions and cytopenia. History of colchicine ingestion had been unknown at time of admission. After initial fluid and electrolyte treatment electrolyte imbalance ameliorated but kidney and liver functions worsened. In the third day of admission (7th day of ingestion), she confessed taking colchicine pills. Her state of consciousness became comatose and endotracheal intubation required. She developed complete heart block requiring temporary transvenous pacemaker implantation in the fifth day of admission. One day after pacemaker implantation, card...

Clinical Manifestations and Outcomes of Colchicine Poisoning Cases; a Cross Sectional Study

Archives of Academic Emergency Medicine, 2020

Introduction: Colchicine is a medication with narrow therapeutic index, leading to both accidental and suicidal poisonings incidents. This study aimed to investigate the clinical and laboratory manifestations, as well as outcomes of colchicine poisoning patients referred to emergency department. Methods: In this retrospective cross sectional study, demographics, clinical features, laboratory parameters, and outcomes of colchicine poisoned patients who were admitted to an academic referral center, Tehran, Iran, during 7 years were extracted from the patients’ profiles and analyzed. Results: 21 patients with the mean age of 25.48 ± 12.65 years were studied (61.9% female; 85.7% suicidal). The mean ingested colchicine dose was 30.25 ± 21.09 mg. The most common symptoms were nausea and vomiting observed in 19 (90.5%) cases, followed by abdominal pain in 10 (47.6%) and diarrhea in 9 (42.8%) cases. 3 (14.3%) had died, the cause being disseminated intravascular coagulation (DIC) in two case...

Case Report: Colchicine Overdose in a Suicidal Attempt A B S T R A C T

2019

Colchicine overdose is uncommon; however, it can cause serious adverse effects and even death. Colchicine inhibits microtubule polymerization, causing mitotic spindle disruption. Ingesting ˃0.5 mg of colchicine per kilogram bodyweight causes severe adverse effects and can even be fatal. Therefore, colchicine toxicity must be accurately monitored and managed. In this case report, we described a 21-year-old woman who attempted suicide by the ingestion of an estimated 30 mg colchicine. She was admitted to the hospital due to severe abdominal and chest pain, vomiting, lethargy, and weakness. The patient was medicated with ondansetron, apotel, antibiotics, platelet transfusions, sodium phosphate, calcium gluconate, calcitriol, desmopressin acetate, Granulocyte-Colony Stimulating Factor (G-CSF), and sodium bicarbonate. Fortunately, through the appropriate medical treatment, the signs and symptoms of colchicine toxicity were relieved and the patient survived despite the high colchicine serum level.