Efficacy of rHVT-AI Vector Vaccine in Broilers with Passive Immunity Against Challenge with Two Antigenically Divergent Egyptian Clade 2.2.1 HPAI H5N1 Strains (original) (raw)
2014
Protection conferred by recombinant HVT avian influenza (rHVT-H5) vaccine in rearing period in two commercial layer chicken breeds in Egypt Walid Kilany, Gwenaelle Dauphin, Abdullah Selim, Astrid Tripodi, Mohamed Samy, Heba Sobhy, Sophie VonDobschuetz, Marwa Safwat, Mona Saad, Ahmed Erfan, Mohamed Hassan, Juan Lubroth & Yilma Jobre a Food and Agriculture Organization of the United Nations (FAO), Emergency Center of Transboundary Animal Diseases (ECTAD), Giza, Egypt b National Laboratory for Veterinary Quality Control on Poultry Production (NLQP), Animal Health Research Institute, Giza, Egypt c Food and Agriculture Organization (FAO), Rome, Italy d General Organization for Veterinary Services (GOVS), Giza, Egypt Accepted author version posted online: 23 Sep 2014.
Avian pathology : journal of the W.V.P.A, 2014
The effectiveness of recombinant turkey herpesvirus avian influenza (A/swan/Hungary/4999/2006(H5N1)) clade 2.2 virus (rHVT-H5) vaccine was evaluated in two layer chicken breeds (White Bovans [WB] and Brown Shaver [BS]). One dose of rHVT-H5 vaccine was administered at day 1 and birds were monitored serologically (haemagglutination inhibition test) and virologically for 19 weeks. Maternally-derived antibody and post-vaccination H5 antibody titres were measured using the Chinese (A/Goose/Guangdong/1/96(H5N1)) HA and the Egyptian (A/chicken/Egypt/128s/2012(H5N1)) HA as antigens. The challenge was conducted at 19 weeks of age and on six experimental groups: Groups I (WB) and II (BS), both vaccinated and challenged; Groups III (WB) and IV (BS), both vaccinated but not challenged; Groups V and VI, unvaccinated specific pathogen free chickens, serving respectively as positive and negative controls. The challenge virus was the clade 2.2.1 highly pathogenic avian influenza H5N1 A/chicken/Egyp...