Lipid–Polymer Hybrid Nanoparticles: Synthesis, Characterization and Applications (original) (raw)
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International Journal of Nanomedicine, 2019
Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs.
Pharmaceutics, 2021
Polymeric lipid hybrid nanoparticles (PLNs) are core–shell nanoparticles made up of a polymeric kernel and lipid/lipid–PEG shells that have the physical stability and biocompatibility of both polymeric nanoparticles and liposomes. PLNs have emerged as a highly potent and promising nanocarrier for a variety of biomedical uses, including drug delivery and biomedical imaging, owing to recent developments in nanomedicine. In contrast with other forms of drug delivery systems, PLNs have been regarded as seamless and stable because they are simple to prepare and exhibit excellent stability. Natural, semi-synthetic, and synthetic polymers have been used to make these nanocarriers. Due to their small scale, PLNs can be used in a number of applications, including anticancer therapy, gene delivery, vaccine delivery, and bioimaging. These nanoparticles are also self-assembled in a reproducible and predictable manner using a single or two-step nanoprecipitation process, making them significantl...
Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery
Journal of Functional Biomaterials
Lipid nanoparticles (LNPs) are spherical vesicles composed of ionizable lipids that are neutral at physiological pH. Despite their benefits, unmodified LNP drug delivery systems have substantial drawbacks, including a lack of targeted selectivity, a short blood circulation period, and in vivo instability. lipid–polymer hybrid nanoparticles (LPHNPs) are the next generation of nanoparticles, having the combined benefits of polymeric nanoparticles and liposomes. LPHNPs are being prepared from both natural and synthetic polymers with various techniques, including one- or two-step methods, emulsification solvent evaporation (ESE) method, and the nanoprecipitation method. Varieties of LPHNPs, including monolithic hybrid nanoparticles, core–shell nanoparticles, hollow core–shell nanoparticles, biomimetic lipid–polymer hybrid nanoparticles, and polymer-caged liposomes, have been investigated for various drug delivery applications. However, core–shell nanoparticles having a polymeric core su...
Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery
Role of Novel Drug Delivery Vehicles in Nanobiomedicine [Working Title], 2019
Applications of nanotechnology and material sciences emerge in the development of various novel drug delivery systems that have been proven as promising clinically. Among these, liposomes, noisome, polymeric carriers and lipid-based delivery system were extensively explored and enter into clinical trials and clinical applications. However, each system has its own pros and cons in term of different physicochemical, pharmacokinetics and therapeutics aspects. Lipid-polymer hybrid carriers merge the potential benefit of these structural components and can be prepared by different approaches to improve the therapeutic outcomes. In this chapter, we provide the useful insight about the lipid-polymer hybrid nanoparticles (LPHNPs) that can be prepared by using the different structural components including the synthetic and natural polymers and lipids. Among these, we also explain the various methods to prepare the LPHNPs with various desired characteristics. Finally, the various therapeutic and clinical applications have been presented briefly.
A Review on Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery
International Journal of Pharmaceutical Sciences Review and Research, 2021
The lipid polymer hybrid nanoparticles have revolutionized the field of nanomedicine through its advantageous features of both the polymeric nanoparticles and liposomes. They exhibit high stability, biocompatibility, selective targeting, prolonged circulation time, greater drug encapsulation efficiency, and significant biological response. These unique properties enable them to be potentially applied in the field of drug and gene delivery.
Insights into the Self assembled Lipid-Polymer hybrid Nanoparticles as Drug Delivery system
International Journal of Scientific Research and Management, 2017
The Use of polymeric nanoparticles and lipid carrier systems, including liposomes, solid lipid nanoparticles and nanostructured lipid carriers has limitations such as drug leakage and high water content of dispersions. Thus, lipid polymer hybrid nanoparticles have been explored by the researchers to provide a better effect using biomimetic characteristics of lipids and architectural advantage of polymeric core and finally producing a system which overcomes the limitations of both polymeric nanoparticles and lipid carrier systems. The system composed of biodegradable polymeric core surrounded by layers of phospholipids, additional compounds and mixtures may also be added to the phospholipids in the amphiphilic coating as for example fatty acids, steroids (such as cholesterol), triglycerides, lipoproteins, glycolipids, vitamins, detergents, and surface active agents. They are generally prepared by mixing liposomes and Polymeric nanoparticles to form lipid-polymer complexes in which a lipid bilayer or lipid multilayers cover the surface of the polymeric core. The space between polymeric core and lipid layer is usually occupied by water or aqueous buffer. The obtained particle size of the final particles remained in the desirable range with narrow distribution. The lipid-polymer hybrid nanoparticle by design has the capacity to co-encapsulate both hydrophobic and lipophilic drugs. The metabolic pathway of lipids in the body has led to the site specific delivery of such system with the modification of the pharmacokinetics and biodistribution of active ingredients for increased efficacy. This hybrid structure provides an advantages of controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on Lipid Polymer hybrid nanoparticles including methods of preparation and physicochemical characteristics.
Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform
ACS Nano, 2008
We report the engineering of a novel lipid؊polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. The NP comprises three distinct functional components: (i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) a hydrophilic polymeric shell with antibiofouling properties to enhance NP stability and systemic circulation half-life;
Scientific Reports, 2017
With recent advances in the field of diagnostics and theranostics, liposomal technology has secured a fortified position as a potential nanocarrier. Specifically, radiation/photo-sensitive liposomes containing photo-polymerizable cross-linking lipids are intriguing as they can impart the vesicles with highly interesting properties such as response to stimulus and improved shell stability. In this work, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine (DTPE) is used as a photo-polymerizable lipid to form functional hybrid-liposomes as it can form intermolecular crosslinking through the diacetylenic groups. Hybrid-liposomes were formulated using mixtures of DTPE and saturated lipids of different chain lengths (dipalmitoylphosphatidylcholine (DPPC) and dimirystoilphosphatidylcholine (DMPC)) at different molar ratios. The physico-chemical characteristics of the liposomes has been studied before and after UV irradiation using a combination of techniques: DSC, QCM-D and solid-state NMR. The results signify the importance of a subtle modification in alkyl chain length on the phase behavior of the hybrid-liposomes and on the degree of crosslinking in the shell. Over decades liposomes have emerged as versatile and promising nanocarrier platforms in the biomedical field as they can be used for encapsulating hydrophobic as well as hydrophilic payloads 1. Despite offering several attractive qualities such as convenient surface functionality incorporation, carrier for wide range of cargo molecules (drugs, vaccines, imaging markers) and possibilities for various routes of administration, the mechanical stability and the inherent leaky nature of the liposomes hinders their potential in the nanomedicine field 2,3. Therefore, improving the shell properties of liposomes and incorporation of controlled release with site-specific delivery aspects have stimulated lot of interests where design of nanocarriers with useful properties has been of great focus 4-7. In this regard, efforts to safely transport drugs/other payloads to the target site by improving shell stability has been paralled by attempts to impart better control on release by rendering liposomes with properties such as response to stimulus or release on trigger 1,8-10. The properties of the liposomes depend on lipid composition, surface charge, size, and the method of preparation 11,12. The 'rigidity' or 'fluidity' of the liposomes depends on the composition of the bilayer 13,14. As compared to conventional liposomes, photo-polymerized vesicles (containing unsaturated phosphatidylcholine species) display enhanced mechanical stability and enhanced retention of lipophilic compounds 15,16. The photo-polymerizable lipids in liposomes upon UV exposure are crosslinked and form polymeric chains which restrict the fluid nature of the membrane 8. Although membrane fluidity of liposomes is an essential cell membrane characteristic for functional interaction with extracellular proteins, rigidity is in turn also important for delivery of drugs at a specific rate 17,18. Generally the polymerization is related to rigidity which gives the membrane enhanced stability 19. In this regard, polymer conjugation or crosslinking of lipids in the membrane can enhance the impermeability of the shell against leakage of active ingredients from the carriers. The latter aspect is very crucial in the design of nanocarriers for drug delivery. As an advantage for the crosslinking lipids, previously, Chen et al. with their liposomal formulation have shown that polymerized liposomes have significantly improved
Self-Assembled LipidPolymer Hybrid Nanoparticles: A Robust Drug Delivery
2008
We report the engineering of a novel lipidpolymer hybrid nanoparticle (NP) as a robust drug deliveryplatform,withhighdrugencapsulationyield,tunableandsustaineddrugreleaseprofile,excellentserum stability, and potential for differential targeting of cells or tissues. The NP comprises three distinct functional components: (i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) a hydrophilicpolymericshellwithantibiofoulingpropertiestoenhanceNPstabilityandsystemiccirculationhalf-life; and (iii) a lipid monolayer at the interface of the core and
Journal of innovations in applied pharmaceutical sciences, 2024
Lipid-based nanoparticles (LNPs) are nano-sized particles composed of lipids, which are natural or synthetic molecules. It comprises of phospholipid bilayer in its structure. The unique properties of lipids such as biocompatibility and versatility, have spurred the development of various lipid based nano formulations. It has different types of lipid-based nanoparticles including liposomes, lipid nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-polymer hybrid nanoparticles. This review focused on the preparation methods and applications of LNPs. The various production techniques, such as injection, sonication, microfluidization, homogenization, microemulsion, nanoprecipitation, and evaporation methods were discussed. Among the various nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and therapeutic outcomes. Additionally, these carriers can enhance the drug distribution, bioavailability, encapsulation efficiency, drug loading capacity, pharmacokinetic properties and thus, results in minimizing the adverse side effects. The LNPs as promising carriers for targeted drug delivery in gene therapy and cancer therapy.