Site-Directed Mutagenesis of Cation Coordinating Residues in the Gastric H,K-ATPase (original) (raw)

Mutational Analysis of the K + -Competitive Inhibitor Site of Gastric H,K-ATPase †

Olga Vagin, Keith Munson

Biochemistry, 2001

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Comparison of Covalent with Reversible Inhibitor Binding Sites of the Gastric H,K-ATPase by Site-directed Mutagenesis

Nils Lambrecht

Journal of Biological Chemistry, 2000

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Structural Aspects of the Gastric H, K ATPase

Jay Shin

Annals of The New York Academy of Sciences, 1997

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Reconstruction of the Complete Ouabain-binding Pocket of Na,K-ATPase in Gastric H,K-ATPase by Substitution of Only Seven Amino Acids

Gijs Schaftenaar

Journal of Biological Chemistry, 2005

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Gastric (H+,K+)-ATPase

Annick Thomas

Biochimie, 1986

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Structural modifications in the membrane-bound regions of the gastric H + /K + -ATPase upon ligand binding

Vincent Raussens

European Journal of Biochemistry, 2001

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Glu-857 Moderates K+-dependent Stimulation and SCH 28080-dependent Inhibition of the Gastric H,K-ATPase

E. Skripnikova

Journal of Biological Chemistry, 1999

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Gastric H,K-ATPase topography: Amino acids 888–907 are cytoplasmic

Adam Smolka

Biochemical and Biophysical Research Communications, 1991

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MECHANISTIC ASPECTS OF GASTRIC (H + + K + )-ATPase

Adam Smolka

Annals of the New York Academy of Sciences, 1982

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Analysis of the membrane domain of the gastric H+/K+-ATPase

George Sachs, Keith Munson

Journal of Experimental Biology

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Extracellular Domains, Transmembrane Segments, and Intracellular Domains Interact To Determine the Cation Selectivity of Na,K- and Gastric H,K-ATPase †

Martin Mense

Biochemistry, 2002

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The Fourth Transmembrane Segment of the Na,K-ATPase ␣ Subunit A SYSTEMATIC MUTAGENESIS STUDY* Received for publication

Saida Guennoun Lehmann

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Deceleration of the E1P-E2P Transition and Ion Transport by Mutation of Potentially Salt Bridge-forming Residues Lys-791 and Glu-820 in Gastric H+/K+-ATPase

Katharina Duerr

Journal of Biological Chemistry, 2010

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Structural interactions between a- and β-subunits of the gastric H,K-ATPase

Adam Smolka

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1995

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Determination of the sidedness of the C-terminal region of the gastric H,K-ATPase α subunit

Keith Munson

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1992

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Changes in Steady-state Conformational Equilibrium Resulting from Cytoplasmic Mutations of the Na,K-ATPase α-Subunit

Stewart Daly

Journal of Biological Chemistry, 1998

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Eight Amino Acids Form the ATP Recognition Site of Na + /K + -ATPase †

Vladimír Kopecký

Biochemistry, 2003

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Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits

Curtis Okamoto

Journal of Biological Chemistry, 1990

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The Gastric H,K ATPase as a Drug Target: Past, Present, and Future

Jay Shin

Journal of Clinical Gastroenterology, 2007

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The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase

Gijs Schaftenaar

Pflügers Archiv - European Journal of Physiology, 2009

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Chemical Modification with Dihydro-4,4′-diisothiocyanostilbene-2,2′-disulfonate Reveals the Distance between K480and K501in the ATP-Binding Domain of the Na,K-ATPase

Jack Kaplan

Archives of Biochemistry and Biophysics, 1997

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Characterization of a Novel Potassium-Competitive Acid Blocker of the Gastric H,K-ATPase, 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438)

J. Shin, Olga Vagin, Keith Munson

Journal of Pharmacology and Experimental Therapeutics, 2011

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cDNA cloning and membrane topology of the rabbit gastric H+/K+-ATPase α-subunit

Keith Munson

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992

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Evidence for a Relationship between Activity and the Tetraprotomeric Assembly of Solubilized Pig Gastric H/K-ATPase

Kazuhiro Oiwa

Journal of Biochemistry, 2005

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Pharmacological profiles of the murine gastric and colonic H,K-ATPases

Michelle Gumz

Biochimica Et Biophysica Acta-general Subjects, 2010

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Functional Consequences of Various Leucine Mutations in the M3/M4 Loop of the Na+,K+-ATPase α-Subunit

yukichi hara

Journal of Membrane Biology, 2008

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Identification of an extracytoplasmic region of H+,K+-ATPase labeled by a K+-competitive photoaffinity inhibitor

Keith Munson

Journal of Biological Chemistry

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Prediction of epitopes and production of monoclonal antibodies against gastric H,K-ATPase

Annick Thomas

Protein Engineering Design and Selection, 1998

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The gastric HK-ATPase: structure, function, and inhibition

Jay Shin

Pflugers Archiv-european Journal of Physiology, 2009

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Ligand docking in the gastric H+/K+-ATPase: homology modeling of reversible inhibitor binding sites

Anthony Watts

2005

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Molecular modeling of the rabbit colonic (HK?2a) H+, K+ ATPase

David Duda

Journal of Molecular Modeling, 2003

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Interaction of α- and β-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase β-subunit

Curtis Okamoto

American Journal of Physiology-Cell Physiology, 2000

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Efficient solubilization and purification of the gastric H+,K+-ATPase for functional and structural studies

Jean-Jacques Lacapère

Biochemical Journal, 2000

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Solubilization and reconstitution of the gastric H,K-ATPase

Annick Thomas

Journal of Biological Chemistry, 1985

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Functional Consequences of a Posttransfection Mutation in the H2-H3 Cytoplasmic Loop of the alpha Subunit of Na,K-ATPase

Stewart Daly

Journal of Biological Chemistry, 1997

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