Pre-emptive Diclofenac Versus Ketoprofen as a Transdermal Drug Delivery System: How They Face (original) (raw)

Dicofenac patch is a novel approach to a less invasive advent of analgesia. Most of the older versions of analgesia were one or other way invasive, which needs the assistance of medical or para medical staff.In older methods like intramuscular or intravenous strict sterile precautions are necessary for proper outcome, sterility of the needle or person who is administering it is needed. Here this method eliminates the need for multiple injections, avoids first pass metabolism and is unaffected by first pass metabolism, definitive role in topical anaesthesia, acute pain management musculoskeletal and neuropathic pain. Diclofenac patches are available at strengths of 100mg, 200mg. Materials and MethodsSample size of 50 each selected for the study randomised by computer generated random number table method study group (I) administered 100 mgm transdermal patch of 100 mgm diclofenac and the control Group (II) patch is not administered.Result and ConclusionQuality of analgesia in the two groups compared by duration of post operative analgesia provided, VAS scoring and the mean dose of rescue analgesic needed. Standard deviation being 1 and 0.2 respectively for Group I and Group II patients. Group I patients mean duration of analgesia being 4.5 hrs and 0.7 hrs respectively. Mean VAS score and mean dose of the rescue analgesic shows from the study that transdermal patch is a comparably good analgesic than control patients. More than this study group peritoneum being a highly painful structure, being breached compared to musculoskeletal structures may be the reason for lesser duration of analgesia for the patch when compared to other clinical conditions.

Aim: This study aimed to compare the analgesic effect of transdermal Diclofenac with oral Diclofenac tablets. Method: In this randomised controlled clinical trial a total of 80 patients were divided randomly in two groups with one group of patients (N1)were given Transdermal diclofenac patch(200 mg) and other group of patients(N2) were given diclofenac tablets after extraction Patients were assessed for pain at various intervals and the assessment of side effects. Results: Significant results were seen at 6 hours with higher number of subjects reporting VAS score 0 and 1-3 in group NI, while subjects reported higher VAS score 4-6 and 7-10 in group N2. Also 20 % of the patients in group N2 (Diclofenac tablet group) complains of gastric irritation after 24 hrs. Statistically no significant difference exists in uniformity of pain control and interference in routine activities during past 24 hours among both the groups. Conclusion: We can conclude that diclofenac patch is more effec...

Newer drug delivery systems such as transdermal patches using pain relieving or modifying agents emerged as a mainstream treatment protocol for management of pain on the outpatient basis. The administration of diclofenac 100 mg in the transdermal patch in the patients having dental pain due to periapical/periodontal infections was evaluated. Ninety patients of either gender, between 18 and 80 years were divided into 3 groups (Group A - oral medication, Group B - transdermal patch, Group C - intramuscular group). Patients at the Dental Department with pain from periapical/periodontal pathologies were explained about the procedure of analgesia. With written consent, 100 mg diclofenac sodium transdermal patches were prescribed to patients who opted their use in pain control for 2 consecutive days. A visual analog scale was provided for all patients assessing the pain intensity during the study. Significant difference in the mean percentage reduction in visual analog scale (VAS) score a...