Baseline and Interferon-Enhanced Natural Killer Cell Activity in Rheumatoid Arthritis (original) (raw)

Abstract

and interferon-enhanced natural killer cell activity in rheumatoid arthritis. Acta path. microbiol. immunol. scand. Sect. C, 93: 79-84, 1985. Natural killer (NK) cell activity against the leukemia cell line K-562 was tested in 45 patients with rheumatoid arthritis (RA) who either had not received any remission-inducing drugs for more than 6 months or had received penicillamine for at least 6 months. Baseline NK cell activity and interferon (IF)-enhanced NK cell activity did not differ from that observed in 45 controls matched for age and sex, and neither NSAID (non steroidal anti-inflammatory drugs) nor penicillamine influenced NK cell activity. There was no correlation between NK cell activity and acute-phase reactants.

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (22)

  1. Berge, R. J. M. Ten, Walbeck, H. K. van & Scalle- kens, Rh. A.: Evaluation of the immunosuppressive effects of cyclophosphamide in patients with multi- ple sclerosis. Clin. Exp. Immunol. 50: 495-502, 1982.
  2. Boyum, A,: Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21, suppl. 97, 1967.
  3. Brunda. M. J., Herberman, R. B. & Holden, H. 1:: Inhibition of murine natural killer cell activity by prostaglandins. J. Immunol. 124: 2682-2687, 1980. Droller, M. J., Schneider, M. U. & Perlman. P.: A possible role of prostaglandins in the inhibition of natural killer cell activity and antibody-dependent cell-mediated cytotoxicity against tumor cells. Cell. Immunol. 39: 165-177, 1978.
  4. Egan, M. L., Medelsohn, S. L., Abo, T. & Bakh, C. M.: Natural killer cells in systemic lupus erythema- tosus. Arthritis and Rheumatism 25: 623-629, 1983.
  5. Fauci, A. S., Dale, D. C. & Balow, J. E.: Glucocor- ticoid therapy: mechanisms of action and clinical considerations. Ann. Intern. Med. 84: 304, 1976.
  6. Herberman, R. B.: Natural Killer (NK) cells and their possible roles in resistance against disease. Clin. Immunol. Rev. I: 1-65, 1981.
  7. Hoffman, T.: Natural killer function in systemic lupus erythematosus. Arthritis and Rheumatism 23: Cantell, K. & Hirronen, S.: Large-scale production of human leukocyte interferon containing 10' units per ml. Gen. Virol. 39: 541-543, 1978. Karsch. J.. Dorval, G. & Osterland, C. K.: Natural cytotoxicity in rheumatoid arthritis and systemic lupus erythematosus. Clin. Immunol. Immunopa- Katz, P., Zaytown, A. M., Lee, J. H.. Panush. R. S. & Longley, S.: Abnormal natural killer cell activity in systemic lupus erythematosus -an intrinsic de- fect in the lytic event. J. Immunol. 129: 1966-1971, 1982.
  8. Kuufman, D. B.: Natural killer augmentation in systemic lupus erythematosus via a soluble media- tor derived from human lymphocytes. Arthritis and Rheumatism 25: 562-567, 1982. 30-35, 1981. thol. 19: 437-446, I98 1.
  9. Makoto, G., Kiyoaki, T., Tadao, C. & Yoshihiko, H.: Natural cell-mediated cytotoxicity in Sjogren's syndrome and rheumatoid arthritis. Arthritis and Rheumatism 24: 1274-1279, 1981.
  10. Makoto. G., Kiyoaki, T. & Yoshihiko, H.: Natural killer cell-mediated cytotoxicity in systemic lupus erythematosus -suppression by antilymphocyte antibody. Arthritis and Rheumatism 23: 1274- 1281, 1980.
  11. Miyasaka, N., Seaman, W., Bakshi, A., Sauvezie, B., Strand, V., Pope, R. & Talal, N.: Natural killing activity in Sjogren's syndrome -an analysis of defective mechanisms. Arthritis and Rheumatism Nagahiro, M.. Ahira, T., Shogo, K. & Fulmanaro, T.: Studies of the function of natural killer-inter- feron system in patients with Sjogren's syndrome. Clin. Invest. 69: 581-588, 1982.
  12. Neighbour, P. A , . Grayzel, A. I. & Miller, A . E.: Endogenous and interferon-augmented natural killer cell activity of human peripheral blood mono- nuclear cells in vitro. Studies of patients with multi- ple sclerosis, systemic lupus erythematosus, or rheu- matoid arthritis. Clin. Exp. Immunol. 49: 11-21, 1982.
  13. Oshimi, K., Gonda. N., Sumiva, M. & Kano, S.: Effects of corticosteroids on natural killer cell activ- ity in systemic lupus erythematosus. Clin. Exp. Im- munol. 40: 83, 1980.
  14. Oshimi, K., Suniya, M.. Gonda. N., Kano, S. & Tahaku, F.: Natural killer cells activity in systemic lupus erythematosus. Lancet ii: 1023, 1979.
  15. Parillo, J. E. & Fauci, A . S.: Comparison of the effector cells in human spontaneous cellular cytoto- xicity and antibody dependent cellular cytotoxicity: Differential sensitivity of effector cells to in vivo 26: 954-960, 1983. and in vitro corticosteroids. Scand. J. Immunol. 8:
  16. Pedersen, B. K., Beyer, J. M., Rasmussen. A., Klar- lund, K., Horslev-Pelersen, K., Pedersen, B. N. & Helin, P.: Azathioprine as single drug in the treat- ment of rheumatoid arthritis induces complete sup- pression of natural killer cell activity. Acta path. microbiol. immunol. scand. Sect. C, 92: 22 1-225, 1984.
  17. Pedersen, B. K., Beyer, J. M., Rasmussen. A,, Klar- lund, K., Pedersen, B. N. & Helin, P.: Methyl- prednisolone pulse therapy induced fall in natural killer cell activity in rheumatoid arthritis. Acta path. rnicrobiol. immunol. scand. Sect. C, 92: 319- 323, 1984.
  18. Penschow, J. & Mackay, I. R.: NK and K cell activity of human blood; differences according to sex, age and disease. Ann. Rheum. Dis. 39: 82-86, 1980.
  19. Sibbitt, W. L., Froelich, C. J. & Bankjurst, A. D.: Abnormal interferon modulation of natural cytoto- xicity in systemic lupus erythematosus. Arthritis and Rheumatism 26: 1452-1459, 1983.
  20. Strannegrird, O., Hermodsson, S. & Westberg, G.: Interferon and natural killer cells in systemic lupus erythematosus. Clin. Exp. Immunol. 50: 246-252, 1982.
  21. Wright, J. K., Hughes, P. & Rowell, N. R.: Lym- phocyte cytotoxicity in systemic sclerosis: no in- crease in short-term culture with established human cells lines. Ann. Rheum. Dis. 41: 414-416, 1982.
  22. Wright, J. K., Hughes, P. & Rowell, N . R.: Sponta- neous lymphocyte mediated (NK cell) cytotoxicity in systemic sclerosis: a comparison with antibody- dependent lymphocyte (K cell) cytotoxicity. Ann. Rheum. Dis. 41: 409-413, 1982. 99-107, 1978.