Abstract TP454: Hemostatic Biomarkers Succeed While Inflammatory Biomarkers Fail To Differentiate Vascular Dementia From Alzheimer’S Disease (original) (raw)

Stroke, 2016

Abstract

Introduction: A reliable plasma biomarker in differentiating between Alzheimer’s disease (AD) and Vascular dementia (VaD) is the need of the hour, in most memory clinics. Hypothesis: We assessed the hypothesis that plasma inflammatory [Interleukin 6 (IL 6) and C-Reactive Protein (CRP)] and hemostatic (Fibrinogen and D dimer) biomarkers can aid in differentiating between AD and VaD. Methods: Neuropsychological assessment, MRI brain, FDG-PET brain and CSF biomarkers of AD (Aβ42 and total tau) were used for establishing the diagnosis of Mild Cognitive Impairment (MCI), AD or VaD. ELISA analyses for IL6, Fibrinogen, D dimer and CRP were performed according to the manufacturers’ protocols. Results: During the study period (January 2013-April 2014), 68 diagnosed patients of AD/MCI/VaD were included. FDG PET brain, plasma fibrinogen, D dimer, IL6 and CRP were done in all 68 patients while 48 patients underwent CSF biomarker analysis. Sixteen patients had MCI, of which 11 were MCI-AD and 5 ...

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