Factors Influencing Tuberculosis Medication Adherence in a Tertiary Health Institution in Nigeria (original) (raw)
Related papers
Adherence to tuberculosis (TB) treatment is a critical factor in determining treatment success. Knowledge about tuberculosis and the belief in the efficacy of the medication influence whether or not a patient chooses to adhere to the treatment. This study determined the factors that influence tuberculosis medication adherence and assessed the impact of a cognitive intervention. The prospective, cross sectional hospital based survey was carried out in Our Lady of Apostle (OLA) Hospital, Jos, Plateau state, Nigeria from October 2014 to January 2015. Structured, interviewer administered questionnaire was used to collect data from 301 respondents. Data collected was analyzed using Statistical Package for Social Sciences (SPSS) version 20.0. The adherence level was 80.5%. The factors significantly (p<0.05) associated with TB medication adherence were ethnicity, religion, alcohol consumption, knowledge of TB disease and DOTs. TB patients were educated on the cause, mode of transmission of tuberculosis and the objectives of the Directly Observed Therapy short course (DOTs) program, which yielded a significant impact (p<0.01). Adherence monitoring plans like home visits and care should be sustained and home based care should be encouraged. Keywords: Tuberculosis, Medication Adherence, Directly Observed Therapy, Cognitive Intervention, Resource Limited Setting
EAS journal of pharmacy and pharmacology, 2024
Background of the study: Tuberculosis is curable and preventable as long as the infected patients take their medication as prescribed without interruption and all preventive measures observed both within the hospital and the community. Adherence to tuberculosis treatment by tuberculosis patients is key to the global control of tuberculosis. Methods: This cross sectional study was carried out at the Mile-4 hospital, a tuberculosis treatment center in Abakaliki, Ebonyi State, Nigeria. A total of 125 tuberculosis patients were recruited for the study and self-administered questionnaires and focus group discussions were used to get responses from the patients. Descriptive and inferential statistics with the aid of SPSS version 20 was used for data analysis. Results: Major reasons given for missing appointment and not following treatment schedule closely were lack of money, long distance from health facility, inadequate health education and non provision of food. Lack of money and long distance from health facility accounted for 60.9% of the reasons for not adhering to the treatment schedule by the tuberculosis patients. Conclusion: Adherence to tuberculosis treatment can be facilitated by extensive health education, minimal financial support and provision of food to tuberculosis patients. Distance from health facilities is also very important in the adherence to anti tuberculosis therapy by tuberculosis patients.
Tuberculosis is a global threat that contributes to disease burden especially in developing countries including Nigeria. Effect of non adherence to directly observed treatments short course (DOTS) leads to continuous infectivity, development of drug resistance and increased mortality associated with Tuberculosis (TB). Therefore, the objective of this study is to identify factors influencing non adherence to directly observed treatments short course among patients with tuberculosis. The study utilized descriptive research design survey. The sample consisted of 163 patients with Tuberculosis using simple random sampling technique. A selfdeveloped structured questionnaire with reliability index of 0.832 was used to collect data. Data collected were coded and analysed using SPSS version 25. Descriptive statistics of frequencies, percentages were used to answer the research questions while the stated hypotheses were analysed using regression. The results from the study revealed high level of non-adherence to DOTS, low level of knowledge on TB treatment. The results further revealed a significant relationship between socio-demographic factors, knowledge of TB treatment and non-adherence to TB medications at 0.05 level of significance. Therefore, the study established a very high level of non-adherence of TB patients to DOTS which is associated with sociodemographic factors and level of knowledge on TB treatments. It is recommended that the stakeholders in the management of TB patient should ensure frequent health educations, increase the numbers of health worker, reduce the duration of time spent in the hospital, improve follow up strategies, and other policies that can lead to improve adherence of TB patients to DOTs
Abstract Tuberculosis remains one of the major health problems in many tropical countries. An estimated eight to ten million people develop overt tuberculosis annually worldwide as a result of primary infection, endogenous reactivation or exogenous re-infection. About half of all patients with TB do not complete treatment and this contributes to prolonged infectiousness, drug resistance, relapse and death. This study is aimed at assessing the adherence of TB patients to anti-TB medications as well as the factors influencing drug adherence in a tertiary health care institution in South-Eastern Nigeria. A descriptive cross-sectional study was conducted among 217 TB patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi. Information was obtained using a self-administered and interviewer administered semi-structured questionnaire. The mean age of the respondents is 36.1 ± 13.3 years. More of the respondents were females (58.1%), while 41.9% were males. It was observed that 74.2% had never failed to take their anti-TB drugs while 24.2% agreed they had failed to take their drugs. The major reasons for failure to take drugs were no money for transport to collect new drugs and forgetfulness by 32.7% of the respondents respectively. The factors which influenced drug adherence were educational qualification, average monthly income, illhealth as a financial burden and receiving HIV drugs (P < 0.05). Adherence towards anti-TB medications is good. However, efforts need to be intensified to educate and encourage TB patients to adhere strictly to their drugs as this will be of great value to them and the community at large.
Adherence to Tuberculosis Therapy in Unilorin Teaching Hospital, Ilorin, North-Central Nigeria
2013
Introduction: Non-adherence to treatment has been one of the main obstacles to the control of tuberculosis. The objective of this study is to investigate the rate of adherence to medication among Tuberculosis (TB) patients. Methodology: This study was a descriptive, cross-sectional survey with analysis of the observed variables in tuberculosis patients. All adults aged 18years and above who were accessing treatment for tuberculosis at the chest clinic of the University of Ilorin Teaching Hospital, Kwara Statewere recruited for the study until the desired sample size of 544 was obtained. The sample size was determined using Fisher’s Formula. Structured, pre-tested interviewer – administered questionnaire was used for data collection and data were analyzed using SPSS version 16. Frequency tables and cross-tabulation of variables were done and pvalue <0.05 was used to determine statistical significance. Result: Respondents who had taken Anti-Tuberculosis drugs for 3-6 months [mean d...
BMC Public Health, 2021
BackgroundTuberculosis (TB) remains one of the most common infectious diseases worldwide. Although TB is curable provided the treatment commenced quickly, appropriately and uninterrupted throughout TB treatment duration. However, high default rate, treatment interruption and therapy non-adherence coupled with inadequate disease knowledge significantly contribute to poor TB treatment outcome, especially in developing countries. This study therefore assessed knowledge about TB and possible reasons for treatment non-adherence among drug-sensitive TB (DS-TB) patients, as well as evaluated treatment outcomes for the DS-TB managed within a 5-year period.MethodsA mixed-method design comprising a cross-sectional questionnaire-guided survey among 140-ambulatory DS-TB patients from January–March 2019, and a retrospective review of medical-records of DS-TB managed from 2013 to 2017 in two WHO-certified TB directly-observed-treatment centres. Data were summarized using descriptive statistics, w...
Adherence to Tuberculosis in Unilorin Teaching Hospital, Ilorin, North Central Nigeria
Abstract: Introduction: Non-adherence to treatment has been one of the main obstacles to the control of tuberculosis. The objective of this study is to investigate the rate of adherence to medication among Tuberculosis (TB) patients. Methodology: This study was a descriptive, cross-sectional survey with analysis of the observed variables in tuberculosis patients. All adults aged 18years and above who were accessing treatment for tuberculosis at the chest clinic of the University of Ilorin Teaching Hospital, Kwara Statewere recruited for the study until the desired sample size of 544 was obtained. The sample size was determined using Fisher’s Formula. Structured, pre-tested interviewer – administered questionnaire was used for data collection and data were analyzed using SPSS version 16. Frequency tables and cross-tabulation of variables were done and p- value <0.05 was used to determine statistical significance. Result: Respondents who had taken Anti-Tuberculosis drugs for 3-6 mo...
Texila International Journal of Public Health, 2020
The aim of this study was to investigate Tuberculosis medication adherence among patients undergoing concomitant treatment for HIV and TB in selected Local Government Areas of Benue State, Nigeria. The study adopts a cross-sectional descriptive survey design using a quantitative instrument to generate information on factors that have significant influence on TB medication adherence among persons using concurrent TB-HIV medication. The overall rate of adherence was 72.7%. Perception of TB disease and TB medication, Family and peer support, Health Service factors, Media and Policy were positively and significantly associated with adherence practice among participants in the study. The study revealed a high prevalence of knowledge (96%) (9.6±0.86) about TB disease among respondents, although knowledge had no significant association with TB medication adherence among the study group. In relation to the socio-demographic characteristics of respondents, analysis of age, gender and level of education did not reveal any significant association with medication adherence and likewise marital status or living arrangement. The study concluded that factors associated with adherence TB medication adherence among persons undergoing concomitant treatment are factors that could be modified with concerted efforts and strategies by stakeholders and health programs to improve adherence levels and cause a decline in the level of non-adherence (27.3%) reported in the study. The study recommends further studies to assess factors that could provide evidence for interventions to help persons suffering from co-morbidities like TB and HIV.
Journal of Tuberculosis Research, 2020
Background: The WHO recommended DOTS has been proven to be very effective in the treatment of tuberculosis (TB) patients. However, despite its effectiveness, non-adherence to the treatment regimen remains a major concern in TB management. This has great consequences which include persistent infectiousness, higher rates of treatment failure, continued transmission, drug resistance, and untimely death. The aim of this study is to examine the factors and behavioural patterns that contribute to treatment adherence among TB patients in Kano State, Nigeria. Methods: A qualitative study design which included two focus group discussions (FGDs) and four key informant interviews (KIIs) were adopted for this study. In total, 20 participants were interviewed comprising 16 focus group discussion participants (8 patients on treatment and 8 individuals who have been cured) divided into two groups and four key informant interviews with 4 health workers in the selected treatment facilities. Data analysis was done by translating and transcribing the responses from the FGDs and KIIs. The transcribed data was analysed using a thematic framework procedure. Results: It was observed that having a good treatment supporter who was effective and very supportive was the most important factor contributing to treatment adherence. Other identified factors that contributed to treatment adherence included: good communication by health personnel, social support from relatives and communities, little or no side effects from drug usage, low cost of transportation to the health facilities, a positive mind set towards drug usage and treatment, support and motivation from health workers, feelings of wellness during treatment, and a balanced diet. All the respondents agreed that treatment adherence had far reaching effects on positive treatment outcomes. Conclusion:
Factors Affecting Tuberculosis (TB) Patient Adherence to Anti-Tuberculosis Drug Therapy in Surabaya
Gaster
Tuberculosis is one of the infectious diseases that causes many deaths in the world. One of the successes in reducing the death rate due to TB is with anti-tuberculosis treatment efforts. However, adherence to treatment is a serious problem because the results are still far from what is expected. The purpose of this study was to determine the level of adherence and what factors affect TB patients in treatment during the pandemic. This research was a descriptive analysis study with a cross-sectional approach. The number of samples was as high as 261 people. The measuring instrument used was the Medication Adherence Rating Scale (MARS). The validity and reliability showed that all questions were valid with a correlation value of > 0.396 and a Cronbach coefficient of 0.803. The results of the bivariate analysis showed that the factors influencing adherence to taking OAT in TB patients were age, education level, employment status, marital status, location of residence, and income lev...