Mechanistic Studies of Antimicrobial Peptides in Lipid Membranes (original) (raw)

Antibiotics with unexplored mechanisms are needed to fight the alarming rise in antimicrobial resistance. Antimicrobial compounds targeting peptidoglycan precursor lipid II, the Achilles' heel of bacteria, can be a suitable template. Therefore, structural studies of membrane mimetic models may provide insights regarding peptide-lipid interactions at atomic resolution. Highlighted in this thesis are the syntheses of peptidoglycan precursor lipid II and its analogues as well as various phospholipids, with the aim of using these synthetic analogues for structural studies on peptides. Some smaller compounds with antimicrobial properties are also explored in this thesis.