A facile method for steroid labeling by heavy isotopes of hydrogen (original) (raw)
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Canadian Journal of Chemistry, 1992
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The Journal of Organic Chemistry, 1993
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European Journal of Organic Chemistry, 2020
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Enantiospecific tritium labeling of 28‐homocastasterone
A regiospecific and enantiospecific synthesis of tritium‐labeled 28‐ homocastasterone is reported. Appropriate chlorocarbonate, efficiently synthesized from the starting 28‐homocastasterone in an overall yield of 46%, undergoes catalytic tritium dechlorination by the T 2 /Pd[0]/Et 3 N system, providing 28‐[3β‐ 3 H] homocastasterone, in a good yield, radiochemical purity (>97%), and with a high specific activity (5.8 Ci/mmol).