Electrokinetics for sample preparation of biological molecules in biological samples using microfluidic systems (original) (raw)

Electrokinetics offers a promising approach for the sample preparation of biological molecules within biological samples, particularly utilizing microfluidic systems. This paper discusses the mechanisms and applicability of electrokinetic techniques for sample clean-up, concentration, and derivatization of large biomolecules like DNA, peptides, and proteins, as well as small molecules critical for therapeutic monitoring. It emphasizes the need for tailored strategies to handle diverse biological targets directly from unprocessed samples, highlighting the integration of these methods into efficient lab-on-a-chip devices, which can significantly enhance the performance and accessibility of diagnostic and monitoring technologies.