Squamous cell carcinoma of the gallbladder (original) (raw)
Related papers
Squamous cell carcinoma of gallbladder: a rare entity
International Surgery Journal
Adenocarcinoma is the most common variant of gallbladder carcinoma. Adenosquamous carcinoma and pure squamous cell carcinoma are rare variants accounting for only up to 3% of the tumors. Pure squamous cell carcinoma of the gallbladder is reported and its incidence is less than 1%. Usually they present at advanced stage and many of the times these are unresectable. Hence survival in patients with squamous cell carcinoma is less than adenocarcinoma, and carries a bad prognosis. We report a rare case of squamous cell carcinoma gallbladder, which was well differentiated, diagnosed early and resected completely. Postoperatively patient is planned for adjuvant chemotherapy.
Modern Pathology, 2011
The information in the literature on squamous cell and adenosquamous carcinomas of the gallbladder is highly limited. In this study, 606 resected invasive gallbladder carcinoma cases were analyzed. Squamous differentiation was identified in 41 cases (7%). Those without any identifiable glandular-type invasive component were classified as pure squamous cell carcinomas (8 cases) and those with the squamous component constituting 25-99% of the tumors were classified as adenosquamous carcinomas (26 cases) and included into the analysis. The remaining 7 that had o25% squamous component were classified as adenocarcinoma with focal squamous change and excluded. The clinicopathological characteristics of adenosquamous carcinoma/squamous cell carcinomas were documented and contrasted with that of ordinary gallbladder adenocarcinomas. The average patient age was 65 years (range 26-81); female/male ratio, 3.8. In only 13%, there was a preoperative clinical suspicion of malignancy. Grossly, 58% presented as thickening and hardening of the wall and 6% were polypoid. In 12%, mucosa adjacent to the tumor revealed squamous metaplasia. All pure squamous cell carcinomas had prominent keratinization. Giant cells and tumor-infiltrating eosinophils were observed in 29 and 51% of the squamous cell carcinomas/adenosquamous carcinomas versus 10% (P ¼ 0.02) and 6% (P ¼ 0.001) in gallbladder adenocarcinomas, respectively. All but three cases had 'advanced' (pT2 and above) carcinomas. Follow-up was available in 31 patients: 25 died of disease (median ¼ 5 months, range 0-20), and 6 were alive (median ¼ 64 months, range 5-112.5). The survival of patients with squamous cell carcinomas/adenosquamous carcinomas was significantly worse than that of gallbladder adenocarcinomas (P ¼ 0.003), and this adverse prognosis persisted when compared with stage-matched advanced gallbladder adenocarcinoma cases (median ¼ 11.4 months, P ¼ 0.01). In conclusion, squamous differentiation was noted in 7% of gallbladder carcinomas. The incidence of adenosquamous carcinoma (defined as 25-99% of the tumor being squamous) was 4%, and that of pure squamous cell carcinoma (without any documented invasive glandular component) was 1%. Pure squamous cell carcinomas often showed prominent keratinization. The overall prognosis of adenosquamous carcinoma/squamous cell carcinoma appears to be even worse than that of ordinary adenocarcinomas. Most patients died within a few months; however, those few who were alive beyond 2 years in this cohort experienced long-term survival.
A Squamous Cell Gallbladder Carcinoma: A Case Report and Literature Review
Emirates Medical Journal, 2020
Squamous Cell (SQC) is a rare type among gallbladder cancer (GBC) and it has a very poor prognosis due to frequent local invasion and advanced stage at diagnosis. Its clinical course and prognostic factors have not been known well until now. The aim of this report is to present an unresectable SQC-GBC case treated by Concurrent Chemo-Radiation Treatment (CCRT) and compare the results of treatment with previously reported case series. This is a case report of a 57 years old female patient, diagnosed with unresectable primary pure SQC of GBC with bile duct invasion and multiple liver and lymph node metastases. She underwent CCRT with best supportive care (BSC), including percutaneous and endoscopic drainage of malignant biliary obstruction, and partial response was achieved. However, the patient was expired due to metastatic invasion of colon and uterus in 10 months after first diagnosis.
Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
Cureus, 2023
Squamous cell carcinoma of the gallbladder is a profoundly rare tumor. It is one of the most aggressive and deadly forms of gallbladder cancer, often being diagnosed at a later stage. There are no definitive risk factors described for this specific type of gallbladder tumor when compared to other forms of gallbladder carcinoma. This case is regarding a 64-year-old female who was found to have primary squamous cell carcinoma of the gallbladder during an attempted cholecystectomy. Her tumor was found to have invaded her liver. The tumor displayed characteristic qualities of a pure squamous cell carcinoma and was positive for CK7 and p63 upon pathological analysis. Best results for treatment for this condition are achieved via R0 resection. Adjuvant therapy with chemoradiation has not been well-defined nor very effective in prior cases.
Squamous cell carcinoma of the gallbladder: an unusual presentation
The Internet Journal of Surgery, 2009
Squamous cell carcinoma (SCC) of the gallbladder is a rare and aggressive affection and is responsible for up to 2% of the malignant neoplasms of this organ. While SCC commonly presents as abdominal lump and/or jaundice, some cases with unusual presentations have been reported in literature. Squamous cell carcinoma of the gall bladder may present rarely as empyema or acute cholecystitis. We report here a rather unusual presentation of a case of a squamous cell carcinoma of the gallbladder in a 60-year-old male presenting as pyoperitoneum.
Turkish Journal of Pathology, 2013
Primary carcinomas of the gallbladder are rare malignancies and adenocarcinoma is the more common subtype. Primary squamous cell carcinoma of the gallbladder has rarely been diagnosed by aspiration cytology. Here, we present a case of a 62-year old female patient suffering from abdominal complaints who underwent ultrasound-guided fine-needle aspiration cytology and was diagnosed as keratinizing squamous cell carcinoma of gallbladder. The diagnosis was confirmed on subsequent histopathological examination that also revealed metastasis in the cystic lymph node. Histogenesis and biological behavior of squamous cell carcinoma of gallbladder remains a matter of debate but the role of aspiration cytology in diagnosing these lesions cannot be undermined.
Primary Pure Squamous Cell Carcinoma of the Gallbladder: Case Report
Surgical Science, 2012
Squamous cell carcinoma of the gallbladder is rare and accounts for about 12.7% of all cases of gallbladder cancer. Pure squamous cell carcinoma is even less common with a reported incidence of 3.3%. We present a case of 72-year-old African-American woman with decreased appetite, fatigue, and weight loss associated with intermittent right upper quadrant pain for two months. Computed tomography of the abdomen revealed a mass in the gallbladder and the hepatic flexure of the colon with involvement of adjacent small bowel. On exploratory laparotomy, a mass at the dome of the gallbladder was found with local invasion of the hepatic flexure, and the proximal transverse colon. There was no obvious involvement of the duodenum, common bile duct, or the extra-hepatic biliary tree. An extended right hemicolectomy, distal small bowel resection, cholecystectomy, a wedge resection of the liver and a feeding jejunostomy, were performed. Pathologic evaluation demonstrated well to moderately differentiated squamous cell carcinoma of gallbladder without evidence of distant metastasis. The patient improved clinically and was discharged home in good condition.
Case Reports in Surgery, 2017
Primary pure squamous cell carcinoma (SCC) of the gallbladder is an exceptionally rare type of tumor that comprises only 1% of all gallbladder cancer. SCC of the gallbladder portends a worse prognosis than the more common adenocarcinoma variant because of its aggressive invasion to local structures and because it is often diagnosed at an advanced stage. Owing to its rarity, diagnosis and management can be challenging. Herein, we present the case of a 75-year-old female complaining of abdominal pain, nausea, and vomiting. Computed tomography and ultrasonography results of the abdomen were consistent with acute cholecystitis and cholelithiasis. Histologic evaluation of the resected mass revealed a malignant tumor with prominent keratinization, confirming the diagnosis of an invasive primary pure SCC of the gallbladder. Microscopic examination showed direct infiltration to the liver, duodenum, and stomach. This case report describes the hospital course of a patient with SCC of the gallbladder and suggests that gallbladder cancer should be considered as part of the differential diagnosis in elderly patients presenting with acute cholecystitis. In addition, this article will review existing literature to examine the utility of different diagnostic techniques and treatment modalities available in the management of gallbladder cancer.