A longitudinal study of bone-related biochemical changes at the menopause (original) (raw)
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Correlates of Biochemical Markers of Bone turnover among Post-Menopausal Women
PubMed, 2018
Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important area of research in low income country like Nepal. This study aimed to examine the correlates of bone turnover markers in post-menopausal women in tertiary level of health care center of Nepal. Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01). Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.
Archives of Gynecology and Obstetrics, 1998
We studied factors related to bone mass after a natural or surgical menopause in 73 healthy women attending the menopause clinic of a university hospital. In the natural menopause group we found inverse correlations between bone mineral density (BMD) vs. menopausal duration; BMD vs. body mass index (BMI) and BMI vs. inorganic phosphate (Pi), borderline correlations between weight vs. thyroxin (T4) and weight vs. luteinising hormone (LH) and a positive correlation between androstenedione (D4A) vs. urinary calcium (Uca). In the surgical menopause group we found some negative correlations (BMD vs. menopausal duration, BMI vs. Pi; BMI vs. dehydroepiandrosterone sulphate (DS), weight vs. DS and cortisol vs. Uca) and some positive correlations (BMD vs. free testosterone (fT), BMD vs. calcium (Ca), and BMD vs. Uca). We concluded that the serum hormone levels we measured were not useful markers of current bone mineral status.
Influence of duration of menopause on bone turnover markers in post-menopausal women
Biomedicine
Introduction and Aim: Osteoporosis is common among women following 10 years of cessation of menstruation, due to bone loss accelerated by menopause. The study was done to evaluate the effect of duration of menopause on bone turnover markers (BTMs). Materials and Methods: The study involved 100 postmenopausal women; 50 osteoporotic and 50 non-osteoporotic. Comparison and correlation of serum calcium, phosphorus, alkaline phosphatase (ALP), serum osteocalcin (sOC) and urinary hydroxyproline (uHP) were done based on duration of menopause. Comparison of biochemical parameters was done using Independent t-test and ANOVA test for two groups and more than two groups respectively. Correlation was done using Pearson’s correlation test. Statistical significance was considered at p<0.05. Results: The sOC significantly declined and uHP levels increased between quartiles of duration of menopause among study participants. (p<0.001). However, in those without fractures, sOC and uHP were ...
Clinical chemistry, 2001
Markers of bone formation and resorption may be useful as early indicators of response to therapy. Our aim in this study was to investigate the use of bone markers for monitoring of intervention for bone loss in early postmenopausal women and to assess the relationships between these markers and changes in bone mineral density (BMD). Subjects were randomly assigned to the following groups: a control group; a group receiving calcium alone; groups receiving calcium plus low or conventional doses of conjugated equine estrogen; and groups receiving calcium plus low or conventional doses of calcitriol. At baseline and at 1 and 3 months after intervention, we measured serum intact osteocalcin, serum N-terminal midfragment osteocalcin, serum C-terminal telopeptide of type I collagen (CTx), urinary deoxypyridinoline cross-links, and urinary CTX: The BMD of the lumbar spine and the femoral neck was measured at baseline and after 1 and 2 years of intervention. No marker changed significantly ...
International Journal of Women's Health, 2017
Background: Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre-and postmenopausal women. Methods: A descriptive cross-sectional study was conducted over a period of 6 months among the female population of Dholahity community, Lalitpur, Nepal. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated as per the guideline provided by the reagent manufacturer, and hormonal assay, particularly estradiol level assessment, was performed by chemiluminescence immunoassay-based technique. Results: A significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women, whereas a significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal (p,0.001). Age was significantly correlated with bone markers (ALP and calcium) in postmenopausal group (p,0.005), while there was no significant correlation in premenopausal group. In addition, there was significant positive correlation between calcium and estradiol in postmenopausal women, while ALP was negatively correlated with estradiol in that group. Further, no significant correlation was demonstrated between estradiol and bone markers in postmenopausal women in body mass index and age-adjusted partial correlation analysis. Conclusion: Timely diagnosis of osteoporosis in women would be of significant benefit for effective care for required populations and help to minimize mortality rate and financial burden of our country.
American Journal of Biomedical Sciences
Menopause is associated with various physiological and biochemical changes that have effects on bone minerals and their metabolism. There have been a lot of complaints about bone pains and bone related problems especially among middle aged women. Thus, the work was designed to assess and compare the levels of parathyroid hormone (PTH), oestrogen and selected bone minerals (calcium and phosphate) in preand post-menopausal women. A total of one hundred subjects were investigated. They comprised fifty premenopausal women within the ages of 20 years and 45 years and fifty post-menopausal women within the ages of 50 years and 65 years. The levels of parathyroid hormone, oestrogen, calcium and phosphate were measured in the subjects. Parathyroid hormone and oestrogen were analyzed using enzyme immunoassay technique while calcium and phosphate were analyzed using spectrophotometric method. The results showed that parathyroid hormone, calcium and phosphate were significantly increased (p<0.05) while there was decrease in oestrogen in post-menopausal women compared with premenopausal women. PTH and oestrogen correlated significantly at (p<0.01) in both pre-and post menopause. This study concluded that postmenopausal women have increased serum levels of parathyroid hormone, calcium and phosphate but decreased serum level of oestrogen. Significant positive correlation exists between PTH and oestrogen in both pre-and post menopause but no significant relationship between PTH and oestrogen with calcium and phosphate.
Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women
Journal of Nepal Medical Association, 2018
Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal. Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause ...
Variations of some biochemical markers in post-menopausal women with and without osteoporosis
Background: Osteoporosis is a silent disease because bone loss occurs without symptoms, resulting in bone fractures and prevention of fracture is dependent on early detection. The prevalence of osteoporosis increases with age due to menopause, which results in decreased production of estradiol and other hormones, leading to reduced bone mineral density. Objective: to describe the variation of some biochemical markers and to observe if these markers could be used as simple tool to predict bone turnover due to osteoporosis, among postmenopausal women. Methods: The physical characteristics were assessed using anthropometric measurements including height, weight, and body mass index (BMI), bone mineral density (BMD) of lumbar and hip were measured by the dual-energy X-ray absorptiometry (DXA) instrument. Random urine and serum calcium, phosphate and serum alkaline phosphatase (ALP) were measured using spectrophotometric kit, while serum levels of parathyroid hormone (PTH) and estradiol (E2) were measured by Enzyme-Link Immune Sorbent Assay (ELISA) techniques in 44 postmenopausal osteoporotic women and 44 healthy women as a control group, aged 50-65 years old. The patients were selected on the basis of inclusion and exclusion criteria. They were recruited from the Al-yarmouk Teaching Hospital, Baghdad, Iraq, between October 2012 and April 2014. This case-control study was conducted at Chemistry and Biochemistry department, College of Medicine, Al-Nahrain University, Baghdad, Iraq. Results: The osteoporotic postmenopausal women had higher mean serum PTH level compared to the healthy women (57.91± 29.03 vs 44.52± 17.08 pg/ml; p=0.0099). The mean serum E2 concentration was significantly higher in healthy postmenopausal women compared to osteoporotic women (51.49± 35.18 vs 34.92± 33.98 pg/ml P=0.0272). There were no significant differences in mean values of Ca+2, P and ALP (p>0.05). There were significant increased in Urinary calcium/Creatinine ratio and Urinary phosphate/Creatinine ratio (259.7±145.33 vs 192.11±119.06 mg/g; P=0.0192); (1368.32±883.66 vs 725.64±721.22; mg/g P=0.0003) respectively, in osteoporotic postmenopausal women compared to healthy postmenopausal women. Lumbar and hip BMD were significantly lower in osteoporotic postmenopausal group as compared with healthy group ( 0.73±0.06 vs 1.13±0.08 g/cm 2; p<0.0001); (0.5± 0.1 vs 0.97± 0.09 g/cm 2; p<0.0001), respectively. Conclusion: Estradiol, parathyroid hormone, urinary Calcium and urinary phosphorus may be useful to predict a bone loss among postmenopausal women.
2021
Background: Menopause accelerates bone loss after 10 years of cessation of the menstrual cycle causing osteoporosis. Hip fractures among postmenopausal women escalate morbidity and mortality in these women. Objective: The study was done to evaluate the effect of duration of menopause on BTMs so that it could detect post-menopausal osteoporosis at the earliest and predict the fracture risk Materials and Methods: The study was conducted in a tertiary hospital in Mangalore on 100 postmenopausal women. The duration of menopause was divided into quartiles. Evaluation and correlation of serum osteocalcin, urinary hydroxyproline, BMI, calcium, phosphorous and alkaline phosphatase was done on the duration of menopause. The subjects comprised 50 osteoporotic and 50 non-osteoporotic post-menopausal women. Continuous variables were represented as median and interquartile ranges. Comparison between two groups was done using the Mann Whitney U test. Comparison between more than two groups was do...
Effect of menopause on bone turn over
Women of all ethnic groups show an accelerated phase of bone loss, which occurs for about 10 years after the cessation of ovarian function. Biochemical assays reflect the turnover of entire skeleton; can detect early changes in the bone turnover. The present study was undertaken to investigate the role of biochemical markers of bone turnover in postmenopausal women. Fifty premenopausal and fifty early postmenopausal women each were selected after the informed consent and 5ml of venous blood was collected. Serum was separated for estimation of total calcium, phosphorous, serum alkaline phosphatase , osteocalcin, total protein & albumin. Urinary Hydroxyproline and Urinary calcium were estimated. Data was analyzed using oneway ANOVA followed by Tukey's test. P value <0.05 was considered the level of significance. Results were expressed as mean ± SD and range values. The serum alkaline phosphatase, osteocalcin and Hydroxyproline were significantly increased in early postmenopausal women as compared to that in premenopausal women. From our study, we conclude that biochemical markers of bone formation and bone resorption was grossly elevated in early postmenopausal women when compared to premenopausal women indicating an accelerated bone turnover in this age group.