Study of in-vitro anti-inflammatory and immunomodulatory effect of Ayurvedic plants – Murva (original) (raw)
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A Controversial Medicinal Plant Murva: A Review
https://www.ijhsr.org/IJHSR\_Vol.11\_Issue.1\_Jan2021/IJHSR\_Abstract.020.html, 2021
Murva is an important medicinal plant used in Ayurveda for the treatment of number of diseases which includes Kushta (psoriasis), Jwara (fever), Pandu (Anemia), Prameha (Diabetes mellitus) and so on. It has been observed that more than one species of plant is used under plant Murva which leads to controversy. Sandigdha Dravya is a term used for medicinal plants having controversial sources, appear in the Ayurvedic classics. The reason for controversy can be listed from one common vernacular name used for two or more different plant species, synonyms and opinion of different authors. Plant based medicines form a very important component of total medicines available for treating various diseases. The increased demand and reduced availability has led to use of different plant species under the name of one plant further arises the problem of controversy. Similarly there is controversy with the drug Murva, that creates huge confusion between different plant sources used in different parts of country. In regards to this purpose, the present work aims to review and differentiate the medicinal plants which are known as Murva.
Background: mussaenda roxburghii hook. Belongs to family rubiaceae, is a perennial shrub moist area of valley and grows in the foothills. Objective: the present investigation was carried out to phytochemicals and pharmacological activity such anti-inflammatory, cardioprotective properties of methanolic crude extract & its fractions such as dcm extract (fraction 1), ethyl acetate extract (fraction2). Materials and methods: residual methanolic extract (fraction 3) of mussaenda roxburghii leaves which were obtained by solvent-solvent extraction process from crude methanolic extract of mussaenda roxburghii. Anti-inflammatory activity was measured by observing the mean inhibition of protein denaturation. Cardioprotective activity was evaluated by thrombolytic assay. Phytochemical screenings have done by using usual procedures. Results: an ex-vivo antiinflammatory test demonstrated that; mean inhibition of protein denaturation 0f 1000/kg of crude methanolic extract of leave of m. Roxburghii was 17.399%. Cardioprotective properties of different extracts of m. Roxburghii was demonstrated which revealed that after treatment of clot with mother methanolic extract, dcm extract (fraction 1), ethyl acetate extract (fraction 2), residual methanolic extract (fraction3) of leaves and methanolic extract of root % clot lysis was 30.56%,27.61%,46.35%,26.02%,49.90 % respectively. Different tests with crude extracts showed that different types of alkaloids, carbohydrates, tannins were present in the leaves of m. Roxburghii. Conclusion: in these investigations demonstrates that different extracts of m. Roxburghii has significant pharmacological activities
Current Drug Targets, 2011
Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation. The transcription factor, Nuclear Factor-kappaB (NF-κB) that controls over 500 different gene products, has emerged as major mediator of inflammation. Thus agents that can inhibit NF-κB and diminish chronic inflammation have potential to prevent or delay the onset of the chronic diseases and further even treat them. In an attempt to identify novel antiinflammatory agents which are safe and effective, in contrast to high throughput screen, we have turned to "reverse pharmacology" or "bed to benchside" approach. We found that Ayurveda, a science of long life, almost 6000 years old, can serve as a "goldmine" for novel anti-inflammatory agents used for centuries to treat chronic diseases. The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit.
2011
Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation. The transcription factor, Nuclear Factor-kappaB (NF-κB) that controls over 500 different gene products, has emerged as major mediator of inflammation. Thus agents that can inhibit NF-κB and diminish chronic inflammation have potential to prevent or delay the onset of the chronic diseases and further even treat them. In an attempt to identify novel antiinflammatory agents which are safe and effective, in contrast to high throughput screen, we have turned to "reverse pharmacology" or "bed to benchside" approach. We found that Ayurveda, a science of long life, almost 6000 years old, can serve as a "goldmine" for novel anti-inflammatory agents used for centuries to treat chronic diseases. The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit.
International Journal of Complementary and Alternative medicine , 2018
Ayurvedic drugs have been used since ancient times in periodontal therapy and Oral diseases. It also reflects the quality of life of the individual. Due to the high prevalence rate, these oral, periodontal and dental diseases continueto be a major threat in India. There are limited references available on the prevention of these diseases in conventional medicines. At this juncture, a glimpse into classical Ayurvedic texts reveals huge potential of many medicinal plants being used. Hence an effective makeshift from synthetic chemicals can be through the medicinal plants mentioned in traditional science. These also serve as a promising approach in prevention and therapeutic strategies of dentistry. Hence, an attempt has been made to understand the phytochemicals contributing to specific actions in oral diseases. Hence, a thorough review has been made in the science of Ayurveda regarding the detailed descriptions of oral diseases (Mukha rogas) by various Acharyas with respect to its diagnosis, examination, management and prevention. A concept has been framed accordingly as a guide to practitioners focusing mainly on the possible role of Ayurveda in the management of Oral Diseases and also to create awareness regarding the usage of medicinal plants in oral diseases.
Crude extracts (in 50% v/v, ethanol) of Vitex negundo L. (Verbenaceae), Argemone maxicana L. (Papaveraceae), Cuminum cyminum L. (Apiaceae), Moringa oleifera Lamk (Moringaceae), Solanum virginianum L. (Solanaceae), Datura metel L. (Solanaceae) and Zingiber officinale Rosc. (Zingiberaceae) were screened for antioxidant and anti-inflammatory related activities. The antioxidant potentials were determined by performing reducing ability assay, 2, 2-diphenyl-1-picryl hydrazine (DPPH) radical and OH radical scavenging activity along with inhibition of polyphenol oxidase: a metal containing model oxidizing enzyme. The amount of major antioxidative substances like phenolics and vitamin C were estimated. The anti-inflammatory related activities such as inhibition of trypsin, β-glucuronidase and conjugated dien formation were carried out to assess the possible anti-inflammatory potential of the selected botanicals. The result of the present investigations show that the plant samples under study were found to be effective reducing agents along with considerable DPPH radical scavenging activity. With few exceptions all the plant samples showed moderate OH radical scavenging potentials and significantly inhibited the generation of hydroperoxides. All the tested plants showed moderate to poor profiles towards inhibition of trypsin, β-glucuronidase and PPO. In the present growing herbal market worldwide the standardisation, authentication and quality control of medicinal plants has remained a major and critical issue in the focus of converting botanical materials into medicines. The results of the present findings may be useful in this context.
Effect of five medicinal plants used in Indian system of medicines on immune function in Wistar rats
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2011
Today, the use (which we can say 'return to nature') of traditional herbal medicines, herbal health products, pharmaceuticals food supplement, cosmetics, etc. is increasing due to the growing recognition that natural products are safe; have either no or negotiable side effects. The objective of this study was to investigate the immunomodulatory properties of five different medicinal plants used in Indian system of medicines on the Wistar rats. The activity was investigated by phagocytic carbon clearance, antibody titre and delayed type hypersensitivity test. The control group received 0.1% carboxyl methyl cellulose and other groups received the different doses of all the five plants extracts such as Tribulus terrestris, Cassia tora, Achyranthes aspera, Mucuna prurians and Abrus precatorius intraperitoneally for 7 consecutive days. All the five plants exhibited immunostimulatory activity and out of the five plants, T. terrestris showed significant dose dependent increase in the 'humoral antibody titre and DTH response' as indicated by increase in footpad thickness. It also showed significant increase in the 'phagocytic index' in rats. The investigation revealed that all the mentioned plants have immunomodulatory activities.
2021
Objective: The present study aims to scientifically validate the analgesic, anti-inflammatory, and antipyretic activities of Mussaenda erythrophylla. Methods: The leaves were excised from the plant, sliced into small pieces, shade dried, and powdered. The powder was extracted with hydro alcohol, concentrated under reduced pressure and the crude extract was referred to as ME. The analgesic, antiinflammatory, and anti-pyretic activity of ME were analyzed in Wistar rats and Swiss albino mice. Results: The results revealed that the hydroalcoholic extract of the leaves of Mussaenda erythrophylla showed a dose-dependent analgesic, anti-inflammatory, and antipyretic activity, which was comparable to the standards, Morphine, Aspirin, Indomethacin, Dexamethasone, and paracetamol respectively. Conclusion: The results of the current study reveal that Mussaenda erythrophylla possesses significant analgesic, anti-inflammatory, and antipyretic activities. Suresh Arumugam1*, Abijith Rajendren R1, ...