The Established Status Epilepticus Trial 2013 (original) (raw)

AI-generated Abstract

Benzodiazepine-refractory status epilepticus (established status epilepticus, ESE) is a common emergency condition requiring effective treatment. This multicenter, randomized, double-blind, Bayesian adaptive trial aims to compare the efficacy of fosphenytoin (fPHT), levetiracetam (LVT), and valproic acid (VPA) in patients older than 2 years. The study will include 795 patients and assess the cessation of clinical seizure activity at 60 minutes post-treatment as the primary outcome. Stratified randomization and interim analyses will ensure the trial's efficiency in identifying the most and least effective treatments.

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