Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi (original) (raw)

2006, The Journal of Immunology

AI-generated Abstract

Cooperative activation of Toll-like receptor 2 (TLR2) and bradykinin B2 receptor (B2R) plays a critical role in inducing type 1 immunity during subcutaneous infection with Trypanosoma cruzi. The study demonstrates that bradykinin, generated through cruzipain activity from the parasite, enhances the immune response by up-regulating IL-12 production in dendritic cells. The absence of TLR2 significantly impairs this immune activation, underscoring the necessity of TLR2 and B2R cross-talk in the immune response to this pathogen.

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