A Review On Antibiotics In An Animal Feed (original) (raw)
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Antibiotics Used in Food Animals: A review
Veterinary medications, particularly antibiotics, are crucial elements in the manufacturing of animal feed. Typically, antibiotics are mostly employed in animals for the purpose of treating and preventing in fections, as well as promoting growth. The utilization of antibiotics in animals can lead to the presence of antibiotic residues in food products, including milk, eggs, and meat. It is possible for these residues to cause a lot of bad things, like the spread of bacteria that are resistant to antibiotics to humans, immune system problems, allergies, and even cancer (with sulphamethazine, and other drugs). The most harmful consequence of residual drugs is the transfer of resistant antibiotic germs to individuals, aided by the mobility traits of resistance. Controlling the consumption of antibiotics in cattle is imperative in order to mitigate these detrimental effects. The issue should be communicated to individuals and local protocols through formal education. This review will discuss the use of antibiotics in food products and their effects on the health of people.
Annals of the New York Academy of Sciences
Globally, increasing acquired antimicrobial resistance among pathogenic bacteria presents an urgent challenge to human and animal health. As a result, significant efforts, such as the One Health Initiative, are underway to curtail and optimize the use of critically important antimicrobials for human medicine in all applications, including food animal production. This review discusses the rationale behind multiple and competing "critically important antimicrobial" lists and their contexts as created by international, regional, and national organizations; identifies discrepancies among these lists; and describes issues surrounding risk management recommendations that have been made by regulatory organizations on the use of antibiotics in food animal production. A more harmonized approach to defining criticality in its various contexts (e.g., for human versus animal health, enteric diseases versus other systemic infections, and direct versus indirect selection of resistance) is needed in order to identify shared contextual features, aid in their translation into risk management, and identify the best ways to maintain the health of food animals, all while keeping in mind the wider risks of antimicrobial resistance, environmental impacts, and animal welfare considerations.
Food animals are often exposed to antimicrobials to treat and prevent infectious disease so as to promote growth. Many of these antimicrobials are identical to or closely resemble drugs used in humans. Precise figures for the quantity of antimicrobials used in animals are not publicly available and estimates vary widely. Antimicrobial resistance has emerged in zoonotic enteropathogens (e.g., Salmonella spp., Campylobacter spp.), commensal bacteria (e.g., Escherichia coli, enterococci), and bacterial pathogens of animals (e.g., Pasteurella, Actinobacillus spp.), but the prevalence of resistance varies. Antimicrobial resistance emerges from the use of antimicrobials in animals and the subsequent transfer of resistance genes and bacteria among animals and animal products and the environment. To slow the development of resistance, some countries have restricted antimicrobial use in feed and similar measures are required in India. Alternatives to growth-promoting and prophylactic uses of antimicrobials in agriculture include improved management practices, wider use of vaccines, and introduction of probiotics.
Veterinary World, 2022
Antibiotics are among the essential veterinary medicine compounds associated with animal feed and food animal production. The use of antibiotics for the treatment of bacterial infections is almost unavoidable, with less need to demonstrate their importance. Although banned as a growth factor for a few years, their use in animals can add residues in foodstuffs, presenting several environmental, technological, animal health, and consumer health risks. With regard to human health risks, antibiotic residues induce and accelerate antibiotic resistance development, promote the transfer of antibiotic-resistant bacteria to humans, cause allergies (penicillin), and induce other severe pathologies, such as cancers (sulfamethazine, oxytetracycline, and furazolidone), anaphylactic shock, nephropathy (gentamicin), bone marrow toxicity, mutagenic effects, and reproductive disorders (chloramphenicol). Antibiotic resistance, which has excessively increased over the years, is one of the adverse consequences of this phenomenon, constituting a severe public health issue, thus requiring the regulation of antibiotics in all areas, including animal breeding. This review discusses the common use of antibiotics in agriculture and antibiotic residues in food/feed. In-depth, we discussed the detection techniques of antibiotic residues, potential consequences on the environment and animal health, the technological transformation processes and impacts on consumer health, and recommendations to mitigate this situation.
Antibiotic residues in animal products and its effect on human health
2019
Antibiotics are mainly employed for chemotherapeutic, prophylactic purposes and also used as feed additives to promote growth and improve feed efficiency. However, antibiotic residues in animal origin products usually found when administration of drug in extra label fashion and does not follow withholding period after treatment. The usage of antibiotic that resulted into deposition of residues in meat, milk and eggs must not be intended for human food consumption. If use of antibiotics is necessary as in prevention and treatment of animal diseases, a withholding period must be observed until the antibiotics residues are negligible to none detected. The concern over antibiotic residues in food of animal origin occurs in two aspects; one which produces potential threat to direct toxicity in human whereas the low levels of antibiotic exposure would result in alteration of microflora, cause disease and the possible development of resistant strains which cause failure of antibiotic thera...
A review of antibiotic use in food animals: perspective, policy, and potential
Public health reports (Washington, D.C. : 1974)
Antibiotic use plays a major role in the emerging public health crisis of antibiotic resistance. Although the majority of antibiotic use occurs in agricultural settings, relatively little attention has been paid to how antibiotic use in farm animals contributes to the overall problem of antibiotic resistance. The aim of this review is to summarize literature on the role of antibiotics in the development of resistance and its risk to human health. We searched multiple databases to identify major lines of argument supporting the role of agricultural antibiotic use in the development of resistance and to summarize existing regulatory and policy documents. Several lines of reasoning support the conclusion that agricultural antibiotics are associated with resistance, yet most public policy is based on expert opinion and consensus. Finally, we propose strategies to address current gaps in knowledge.
Appropriate Regulation of Antibiotics in Livestock Feed
For decades, antibiotics have been widely used, saving lives and reducing suffering. Such drugs are routinely employed among both human and farm animal populations. However, scientific data now links the use of antibiotics at subtherapeutic levels in livestock feed to the spread of antibiotic resistant bacteria in the human population. After examining the current research, this Article concludes that despite short-term economic benefits associated with the widespread use of antibiotics in agriculture, the risk to human health justifies a change in policy. This Article recommends a number of steps to minimize the spread of antibiotic resistance. The primary changes would be to phase out the use of antibiotics as livestock feed additives, and to refuse to approve new drugs for this purpose. In either instance, this use would be permissible if the drug sponsor provides convincing evidence that the agricultural use of its particular antibiotic presents no appreciable risk to human health.
Antibiotic Use in Livestock and Residues in Food—A Public Health Threat: A Review
Foods
The usage of antibiotics has been, and remains, a topic of utmost importance; on the one hand, for animal breeders, and on the other hand, for food safety. Although many countries have established strict rules for using antibiotics in animal husbandry for the food industry, their misuse and irregularities in compliance with withdrawal periods are still identified. In addition to animal-origin foods that may cause antibiotic residue problems, more and more non-animal-origin foods with this type of non-compliance are identified. In this context, we aim to summarize the available information regarding the presence of antibiotic residues in food products, obtained in various parts of the world, as well as the impact of consumption of food with antibiotic residues on consumer health. We also aim to present the methods of analysis that are currently used to determine antibiotic residues in food, as well as methods that are characterized by the speed of obtaining results or by the possibil...
Bacteria in Animal Feed and Their Susceptibility to Antimicrobial Drugs
Archives of Veterinary Medicine
Control of microbiological safety of animal feed is regulated by a law. The regulation is based on methodological standards for estimation of feed quality. Those methods are permanently amended and strive for continuous improvement of microbiological safety of feed. The question remains whether the presence or absence of some bacterial species is sufficient for proper assessment of feed safety. The answer to this question can be found not only in the examination of the number of bacteria in animal feed, but also in qualitative analysis of the isolated microorganisms. The sensitivity of bacteria from animal feed to antimicrobials is one of the qualitative characteristics of microorganisms that can affect food safety even if the feed meets the standards and is within the maximum permitted level. The subject of our work was to determine the presence of bacteria in animal feed with a purpose to examine if they possess lower sensibility to antibiotics. For testing antibiotic sensitivity ...