A novel technique to measure the sucrose concentration in hydrogel sucrose solution using two dimensional photonic crystal structures (original) (raw)

Measurement of Sucrose Concentration Using Optical Metamaterial Structure Via FDTD Technique

IETE Journal of Research, 2020

The current communication deals with the investigation of sucrose concentration in aqueous solution using copper-based metamaterial structure at a wavelength of 1550 nm. In this article, 5 × 5 air holes are engraved on a copper-based metamaterial structure, which contains the different concentration of sucrose in aqueous solution. Further, the present structure manipulates with finite difference time domain (FDTD) technique to compute the sucrose concentration. Moreover, different losses (absorption loss, dispersion loss, propagation loss, and polarization loss) are measured for the same. Nevertheless, similar type of papers have been published, the present paper has a couple of benefits including the method of computation (FDTD) and the output variation (linear ship) with the concentration. Apart from this, the present research shows the error bar, which deals with an accurate measurement. Again a mathematical model is also obtained, which gives the relationship between the sucrose concentration and the output intensity. Further, output results declared that transmitted intensity varies linearly with the concentration of sucrose. Lastly, a feeble error in the commutation proclaims an accurate investigation of sucrose in their aqueous solution with the help of a photonic structure.

Comparing the Light Response of D-Glucose in Polyacrylamide Hydrogel and Water in NIR Spectral Region by Using an LED Based Portable Device

2022

The spectral properties of the molecules depend on the matrix in which it is present. The interaction of the molecule with the solute molecules affects the vibrational and rotational modes of the molecule. In this study, an absorption-based system was designed to show how the absorbance properties of glucose change in polyacrylamide hydrogel, and the measurements were performed at different wavelengths; 960 nm, 1450 nm, 1550 nm, and 1950 nm. It was observed that the system is sensitive to glucose at 1450 nm and 1950 nm wavelengths in polyacrylamide hydrogel, whereas it is only sensitive at 1450 nm in water which is due to the high absorbance of water at 1950 nm. In polyacrylamide hydrogel, water molecules mostly gather around the polymer chains via electrostatic interactions and the absorbance of water decreases which results in an increasing absorbance of glucose. According to the results, the responsivity of the system at 960 nm and 1550 nm, which are the wavelengths commonly used...

Design of Photonic Crystal-Based Biosensor for Detection of Glucose Concentration in Urine

IEEE Sensors Journal, 2015

In this paper, we have demonstrated and designed a 2D photonic crystal-based biosensor with line defect, which can detect glucose concentration in urine. Simulation and analysis have been done in order to detect glucose concentration in normal urine (0-15 mg/dL), urine with 0.625, 1.25, 2.5, 5, and 10 gm/dL of glucose concentration in the wavelength range of 1530-1565 nm. Finite-difference time-domain method has been used for the analysis. Massachusetts Institute of Technology electromagnetic equation propagation and MIT photonic bands simulation tools have been used for modeling and designing of photonic crystal, and IPKISS software framework has been used for generation of mask design, which can be used for the fabrication of the photonic crystal sensor. It has been observed from the band structure that for little change in refractive index, there will be a moderate shift in the frequency and transmitted output power and hence it acts as a sensor. This indicates that it is highly sensitive for the change in refractive index.

Photonic crystal borax competitive binding carbohydrate sensing motif

The Analyst, 2009

We developed a photonic crystal sensing method for diol containing species such as carbohydrates based on a poly(vinyl alcohol) (PVA) hydrogel containing an embedded crystalline colloidal array (CCA). The polymerized CCA (PCCA) diffracts visible light. We show that in the presence of borax the diffraction wavelength shifts as the concentration of glucose changes. The diffraction shifts result from the competitive binding of glucose to borate, which reduces the concentration of borate bound to the PVA diols.

An Analysis and Design of Photonic Crystal-Based Biochip for Detection of Glycosuria

IEEE Sensors Journal, 2015

In this paper, a 2-dimensional "Air holes in silicon slab" photonic crystal based structure with line defect has been designed and simulated for detection of high glucose concentration in urine from 0-15 mg/dl to 10 gm/dl in the wavelength range of 1530-1565 nm. High glucose concentration in urine is referred as "Glycosuria". The proposed sensor structure is modeled and simulated in time domain by using MEEP (MIT Electromagnetic Equation Propagation) simulation tool. Finite Difference Time Domain (FDTD) method has been used for the analysis. Band structure has been computed and Eigen frequencies have been extracted for each k-point for the designed sensor structure by using MPB (MIT Photonic Bands) simulation tool. The changes in the normalized output power levels, Quality (Q)-factor and resonant frequency have been observed for different concentrations of glucose present in urine. The calculated value of Q-factor obtained is Q=23575. The study has been done for normal urine and glycosuric urine. It is clear from the simulated graphs of transmission spectrum and band structure that for minute changes in the refractive index, the transmitted output power level range varies from 0.2298 dB to-0.091 dB and the resonant frequency range varies from 0.229259-0.22914 (in units of c/a) and hence it acts as a sensor for detection for "Glycosuria". Our designed sensor has achieved sensitivity of 638 nm /RIU.

Metamaterial based sucrose detection sensor using transmission spectroscopy

Optik, 2020

In the present study, metamaterial based optical sensor is proposed and optimization of the proposed optical sensor for sucrose detection is done. In this paper single negative metamaterial surface is fabricated using E-beam lithography technique to be used as an optical sensor for broad wavelength range using UV-Vis-NIR spectrometer. The resultant sensitivity and detection accuracy of the proposed metamaterial based sensor is higher than simple thin film sensor, i.e. 1740.8 (nm/RIU) and 0.893 respectively. The center wavelength of the proposed optical sensor is 967 and 933 nm for gold and metamaterial based-sensor respectively, which ensures the larger bandwidth available in the case of metamaterial based-sensor. It is observed that high surface to volume ratio of metamaterial surface ensures the better sensitivity of the proposed sensor. Simple structure of presented metamaterial surface also makes sure reliable and precise fabrication of metamaterial surface.

Polymerized Crystalline Colloidal Array Sensing of High Glucose Concentrations

Analytical Chemistry, 2009

We are developing photonic crystal glucose sensing materials to continuously monitor relatively high glucose concentrations, such as found in blood. We modified our synthetic fabrication methodologies in order to increase the glucose concentration range and to increase the reproducibility of our PCCA fabrication. We have also advanced our understanding of the sensing response by developing a mechanical method to independently determine the hydrogel cross-link density. Our investigation of the sensing mechanism indicates that glucose binding depends mainly on the boronic acid concentrations and affinities. We determined the binding constant of 2-fluoro-5-aminophenyl boronic acid for glucose under physiological conditions. We have examined the dependence of glucose sensing upon interferences by other species that ligand to boronic acids, such as lactate and human serum albumin. We examined the stability of our sensors over a period of weeks at room temperature and demonstrated that we could further stabilize our sensing materials by reversibly dehydrating them for storage.

Analysis and optimization of a hydrogel matrix for the development of a sandwich-type glucose biosensor

Sensors and Actuators B: Chemical, 2015

The development of a sandwich-type biosensor for glucose quantification is presented. This work is focused on the optimization of the enzymatic matrix of the biosensor. The best performance was found for an enzymatic matrix composed by 30% w/w mucin, 70% w/w albumin, 1.35 U glucose oxidase (GOX) per sensor, and glutaraldehyde diluted to 3%. The crosslinking with glutaraldehyde transforms this mixture into a hydrogel that is entrapped between two membranes of polycarbonate. The selected sandwich-type biosensor showed very good response time, sensitivity, stability, and sensor-to-sensor reproducibility. According to the results presented in this manuscript, a biosensor prepared with very high amount of enzyme would not necessarily increase the analytical signal. Simulated curves are compared with experimental data to explain the dependence of sensitivity on the concentration of enzyme. In addition, this kind of comparison represents a quite simple way to estimate the value of v max ≈0.13 M s −1 from the amperometric response of a sensor prepared with 1.34 U of GOX. Considering that sandwich-type biosensors are commonly assembled as part of devices where the sample is diluted with buffer, the more than 3 orders of magnitude of linear behavior of this sensor would ensure the possibility for assessing any sample.