Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus (original) (raw)

This review article discusses the challenges posed by the human respiratory syncytial virus (hRSV) in terms of vaccine development due to the absence of a single animal model that fully mimics human pathology. The significance of various animal models, particularly the murine model, is evaluated alongside other alternatives like mustelids, ruminants, and non-human primates. Each model's advantages and limitations are examined to highlight their roles in understanding the pathology of hRSV and inform future vaccine and therapy development.