Myricetin solid lipid nanoparticles: Stability assurance from system preparation to site of action (original) (raw)
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Pharmaceutical Nanoencapsulation Strategies : A Mechanistic Review
2013
Colloidal solid particulates of size in nano range with an upper size limit of approximately 1000 nm are called as nanoparticles which include nanospheres (matrix systems) and nanocapsules (reservoir systems). Literature reveals numerous advantages and successful application of nanoparticles in drug therapy. Nanoparticles has proven as active vectors due to their capacity to release drugs; their subcellular size allows relatively higher intracellular uptake than other particulate systems; they can improve the stability of active substances and can be biocompatible with tissue and cells when synthesized from materials that are either biocompatible or biodegradable. Polymeric nanoparticles have been significantly exploited as drug carriers. This review is an attempt to provide summarized information on the various approaches for fabrication of drug loaded nanocapsules.
International Journal of Applied Pharmaceutics, 2024
Objective: Aim of the present study was the development, optimization and evaluation of myricetin-loaded nanoemulsion gel for wound healing. Methods: Myricetin nanoemulsion was prepared by selecting Peanut oil as oil (wt %), Tween 20 and Polyethylene glycol 400 as surfactant and cosurfactant (Smix) and aqueous phase water. Performance of nanoemulsion gel was evaluated by wound healing activity tested against wound contraction, hydroxyproline content, protein content and antioxidant assay. Results: The optimized nanoemulsion (NEF1) exhibited appreciable stability concerning droplet size and PDI when stored at 5 ᵒC, 25 ᵒC and 40ᵒC up to three months. Morphological characterization by TEM indicated a spherical shape. Wound healing effect was observed through a significant (p<0.5) increase in hydroxyproline content, protein content and antioxidant status in wound tissue. The level of superoxide dismutase (SOD) and catalase were found to increase significantly in wound tissue after treatment with Myricetin loaded nanoemulsion (MYCT-NE) gel, as well as results were comparable to Betadine cream. Conclusion: In conclusion, MYCT-NE gel was found potent wound healing effect through the reduction of oxidative stress and epithelialization of tissue.
DEVELOPMENT AND EVALUATION OF SUSTAIN RELEASE MICROPARTICLES OF METOPROLOL SUCCINATE
International Journal of Applied Pharmaceutics, 2019
Objective: In this study, xanthan gum was oxidized by sodium periodate to form xanthan dialdehyde. This oxidized gum was used as crosslinking agent as an alternative to somewhat toxic glutaraldehyde, the basis of which is the reaction between the Schiff reagent and the aldehydes formed by periodate oxidation. Methods: Formation of aldehyde groups were confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Microparticles of metoprolol succinate were fabricated using crosslinking of a chitosan/gelatin mix system by dialdehyde Xanthan gum. The properties of the developed microparticles were investigated with swelling equilibrium studies, differential scanning calorimeter (DSC), in vitro drug release studies and scanning electron microscopy (SEM). Results: The in vitro drug release from these microparticles was affected by total polymer amount, oxidation reaction time and chitosan to gelatin ratio. The cumulative percent release of metoprolol succinate was observed within the range of 46 to 95% at 8 h from different formulations studied. The factors identified as significant to produce any impact on drug loading as well as drug release were both the polymer and inter actions of polymer and Xanthan gum dialdehyde. Conclusion: The release mechanism followed the super case II model kinetics.
Nanoencapsulation Systems for Bioactive Compounds
Nanotechnology in Functional Foods, 2022
Bioactive compounds are capable of bestowing numerous health advantages. However, incorporation of the same into food products and their delivery is a cause of concern mainly due to chemical instability, susceptibility toward oxidative and gastrointestinal degradation as well as insolubility in body fluids. Application of nanotechnology, especially nanoencapsulation with particles of diameters between 1 and 100 nm has been observed to solve the above issue, thereby aiding in increased bioavailability and functionality of the aforesaid compounds. Moreover, their low cost and biodegradability further qualify them as suitable food transportation agents. Different nanoencapsulation systems can be used, including lipid-based carriers, protein nanocapsules, and polysaccharide nanoparticles. Selection of an appropriate nanocarrier is dependent on the type of the biological material, production method, and the kind of food. Lipid nanoparticles can be used to encapsulate several phytochemicals possessing a range of polarities. Moreover, protein and polysaccharide nanovehicles have exhibited regulated and prolonged release of biomolecules. The present article highlights the features of various nanoencapsulation systems along with their advantages and applications as carriers of nutraceuticals. A deeper understanding of the above may aid in successful utilization of nanocapsules for effective distribution of bioactive compounds.