Various components in the magnetoencephalographic responses evoked by the human face images (original) (raw)
2009, Neuroscience Research
Electrical stimulation applied to visual cortex is known to evoke phosphen in blind patient, indicating a possibility of cortical implant. However, it is not well understood how electrical stimulation activates cortical neuronal circuits. We investigated the spatiotemporal properties of electrically induced response in mouse primary visual cortex (V1) using voltage-sensitive dye. A biphasic current stimulation was delivered to layer 4 of V1 by glass microelectrode. Stimulation (> 40 A) to layer 4 induced response around the electrode and spread laterally to nearby area. The amplitude and the area of response became larger as the stimulation current and the response was recorded occasionally in latero-medial area. Electrical stimulation on the superficial layer (layer 1) was less effective. Stimulation on deeper layers (layers 4 and 5) induced the larger and more widely spreading activity that was followed by a slow negative response, possibly corresponds to hyperpolarization of cells.
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.