From the breast to the upper jaw: A rare case of metastatic breast cancer (original) (raw)

Maxillofacial metastasis from breast cancer

Pan African Medical Journal, 2014

Metastatic tumors to paranasal sinuses are exclusively rare. In this paper, we report acase of breast carcinoma metastasizing to the right maxilla.

Metastatic breast cancer in a Nigerian tertiary hospital

African health sciences

Late presentation of breast carcinoma is common in resource-limited countries with attendant poor outcome. To describe the pattern of clinical presentation and challenges of treating patients presenting with metastatic breast carcinoma in a Nigerian hospital. Clinical records of all patients who presented with metastatic breast carcinoma between January 1991 and December 2005 at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria were reviewed. More than half of all histologically confirmed breast cancer patients seen within the study period presented with metastatic disease. Their ages ranged between 20-81 years with a mean age of 45.9 years. Only 3% (6 of 202) were males. Two-thirds had more than one secondary site on initial evaluation and the commonest sites were liver (63%), lung parenchyma (51%), pleura (26%) and contralateral breast in 25%. On immunohistochemistry, basal like tumours were found in 46.1%. Mastectomy was done in 37 patients with fungatin...

Rare metastasis of breast cancer to mandible - a case report

Libri Oncologici Croatian Journal of Oncology, 2019

Breast cancer is the most common cancer in the female population. In Croatia, breast cancer makes up to 26% of all newly diagnosed cases of cancer in females. Breast cancer primarily metastasizes to bones, lungs, liver, brain and lymph nodes. We report a case of isolated metastasis of breast cancer to mandible in a 76-year-old female patient, who was diagnosed with cancer eleven years ago, which presented with diffi cult chewing, discrete pain, and continuing increase in tumor marker Ca15-3. Pathohistology of intraoral biopsy confi rmed a breast cancer metastasis. The patient received with palliative radiotherapy and hormone therapy. Every oncological patient complaining about the disorders in the mandibular area must be subject to thorough examination and metastasis should be included in the diff erential diagnosis. Metastatic lesion in the mandible is a sign of disseminated disease, and the treatment is most often palliative.

Breast metastasis from squamous cell carcinoma of the oropharynx: a case report

Journal of Medical Case Reports, 2017

Background: Breast metastases from extramammary tumors are extremely rare, the most common primary tumors being contralateral breast carcinoma, followed by lung, gynecological, gastrointestinal, melanoma, and hematological cancers. Only a few cases deriving from head and neck squamous cell carcinoma have been reported in the literature to date. Case presentation: We report a case of a 47-year-old Caucasian woman who presented to our hospital with a solitary breast lesion in the right upper external quadrant associated with multiple bone and visceral metastases. Two years before, she had undergone radical resection of a squamous cell carcinoma of the oropharynx (stage pT2, pN1), which was followed by adjuvant radiotherapy. Breast ultrasound showed a hypoechogenic tumor lesion of 4 cm in the right upper external quadrant that was associated with multiple axillary and infra-/supraclavicular adenopathies. A positron emission tomographic scan documented multiple visceral and bone metastases with a single hypermetabolic lesion of the right breast. The results of histology and immunohistochemistry were consistent with a metastasis from a squamous cell carcinoma. The patient died of acute respiratory insufficiency 1 month after her breast metastasis diagnosis and before starting any systemic antitumoral treatment. Conclusions: Although breast metastases are extremely rare, they should be considered in any patient with a history of cancer and confirmed by histology and immunohistochemistry because they are very difficult to distinguish from other primary breast tumors based only on clinical and radiological features. There are no standardized treatment guidelines for breast metastasis management. Surgery and radiotherapy can play a role in symptom palliation, but they do not have any relevant impact on survival, the prognosis being poor, with an estimated overall survival less than 1 year from diagnosis.

A Case Report on Mandibular Metastasis From a Breast Carcinoma

Cureus

Despite the rise in the number of cases of breast cancer in recent years, clinical diagnosis of a primary tumor in cases presenting with metastasis to the oral cavity poses a challenge in modern medicine because of its rare presentation. We report a case of breast cancer which presented as a painless swelling in the jaw. A 37-year-old multiparous woman consulted her dentist with complaints of toothache and swelling over the right cheek. On examination, she was diagnosed with dental caries and an orthopantomogram (OPG) was done to evaluate the swelling which revealed an area of rarefaction with an irregular margin on the right angle of the mandible. With suspicion of malignancy, the head, neck, oral and pharyngeal regions were thoroughly inspected and palpated. An ultrasonogram (USG) of the neck was done, which was normal and a core needle biopsy of the oral swelling was performed which showed metastatic carcinomatous deposits with pancytokeratin (PAN-CK) positivity, estrogen receptor (ER) positivity, and the Ki-67 value was 10% to 20% which was suggestive of breast carcinoma metastasis. Thereafter, the patient was referred for a surgeon's opinion. A breast examination was then done which revealed a lump in the right breast with a retracted nipple. A core needle biopsy of the lump revealed that it was ER and progesterone receptor (PR) positive and human epidermal growth factor receptor 2 (HER-2/neu) negative which confirmed the clinical diagnosis of breast cancer. Since the incidence of oral metastatic tumors is low, the likelihood of an early diagnosis of the distant primary tumor is reduced. Hence, all lesions of the oral cavity should be evaluated with due diligence considering the possibility of it being secondary metastases from distant tumors.

Breast carcinoma metastasis to the cheek: a case report

Journal of Medical Case Reports, 2022

Background Breast carcinoma is a common tumor in women, but it rarely metastasizes to the oral region. Furthermore, metastases to the oral region occur mainly to the maxillary and mandibular bone and rarely to soft tissue. Case presentation We describe a case of breast cancer metastasis to the buccal area. Examination of the right buccal mass of a 66-year-old Japanese woman was suggestive of breast cancer metastasis, and a breast lump was detected. Since receiving hormone-based treatment, the patient has survived more than 5 years and is now in remission. Conclusions An oral metastatic lesion may be the first sign of breast carcinoma; oral surgeons should be aware of this possibility.

Report of six cases of metastatic jaw tumours in Nigerians

Background: Metastatic tumours make up approximately one per cent of all oral malignancies. Such tumours may present in the jawbones and oral soft tissues. The commonest oral site is the mandible. Nigerian reports of metastatic tumours to the jaws are very rare. Method: This is a retrospective study of six cases of metastatic tumours to the jaws seen at the Maxillofacial Unit, Ahmadu Bello University Hospital, Kaduna from1979-1998,representing 1% of all histologically confirmed malignant jaw tumours in the hospital. Results: Unlike in other reports, most (three of our six cases) originated from the thyroid gland while the rest were from the breast, uterus and the nasopharynx. More of our lesions occurred in the mandible (4) than the maxilla (2) and almost all patients presented with oral complaints oblivious of the primary malignancy. These complaints resemble those from odontogenic infections and benign neoplasms. The most common histological type of metastatic tumours in this stud...

Oral and maxillofacial metastasis of male breast cancer: Report of a rare case and literature review

Oral surgery, oral medicine, oral pathology and oral radiology, 2018

Oral and maxillofacial metastatic tumors are uncommon, with the breast, prostate, lung, and kidney representing the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date, only 8 cases of metastatic breast adenocarcinoma to the oral and maxillofacial region in a male patient have been reported in the literature. An 88-year-old male with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling lasting 6 months. Intraoral examination revealed a 2-cm reddish, pedunculated nodule with a smooth surface located in the left retromolar region. Imaging revealed maxillary sinus involvement. The patient underwent incisional biopsy, and microscopic evaluation revealed invasive tumor islands compounded by malignant epithelial cells, sometimes exhibiting ductal arrangement, which were positive for the estrogen receptor and gross cystic disease fluid protein 15. The final dia...

Jaw Pain as a First Presentation in the Diagnosis of Breast Cancer

Iranian journal of pathology, 2016

The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, was referred to the Department of Medical Oncology of Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2014, presented with pain and tenderness in the left mandibular and temporal bone and paresthesia of the lower left lip and chin. CT scan of mandible showed no significant finding. Four months later, she was referred with complaints left breast pain for 4 wk and worsening swelling, pain and paresthesia. Breast examination revealed a 2 cm firm nodule on the left breast. Based on her medical history and histopathological study, metastatic carcinoma of the breast was suspected. She has received chemoradiotherapy that led to complete relief of her sympt...

Metastasis of Breast Cancer to the Mandibular Gingiva: Report of a Rare Case

Middle East Journal of Cancer, 2020

Metastatic tumors to the oral cavity are rare and account for only 1% of all oral cavity malignancies, and if occurs, it involves the jaws rather than the soft tissue. Diagnosis of a metastatic lesion in gingiva can be challenging owing to its rarity and atypical appearance. In this paper, we describe a rare case of breast cancer metastasis to the gingival soft tissue of mandible. A 68-year-old female referred to the department of oral and maxillofacial surgery with the chief complaint of a painful mass in the right buccal and lingual anterior region of the mandible with the mobility of the involved teeth. The patient also reported the history of a breast cancer dating back to eight years ago. Histopathologic findings and immunohistochemistry results supported a metatatic lesion. As a result, it is important to have a great clinical suspicion to diagnose such lesions in order to receive the most proper treatment to patients as soon as possible.