Analysis of non-pharmaceutical interventions impacts on COVID-19 pandemic in Iran (original) (raw)

COVID-19 infection control parameters in Iran: an epidemiological modeling

Novelty in Biomedicine, 2021

Background: We aimed to evaluate Iran's current COVID-19 infection, emphasizing the number of infection detection and the disease's reproductive number in its high peak in November and after the lockdown in December. Materials and Methods: Using the Johns Hopkins Bloomberg School of Public Health Contact Tracing Evaluation and Strategic Support Application, we used the average weekly new cases and average case mortality in November and December 2020. The average case isolation and identification time (25%, Four days) and the average case contact within the household and community were entered into the application. We examined Two modeling systems with 50% and 70% case isolation for the November period as alternative scenarios for the current infection control rate. Results: Our modeling showed only 11% and 30% of the infections were detected in November and December. The disease's reproductive number is similar to the natural reproductive number of the disease (2-3) in N...

Control of COVID-19 outbreak using an extended SEIR model

Mathematical Models and Methods in Applied Sciences, 2021

The outbreak of COVID-19 resulted in high death tolls all over the world. The aim of this paper is to show how a simple SEIR model was used to make quick predictions for New Jersey in early March 2020 and call for action based on data from China and Italy. A more refined model, which accounts for social distancing, testing, contact tracing and quarantining, is then proposed to identify containment measures to minimize the economic cost of the pandemic. The latter is obtained taking into account all the involved costs including reduced economic activities due to lockdown and quarantining as well as the cost for hospitalization and deaths. The proposed model allows one to find optimal strategies as combinations of implementing various non-pharmaceutical interventions and study different scenarios and likely initial conditions.

Covid-19: an analysis of an extended SEIR model and a comparison of different intervention strategies

arXiv: Populations and Evolution, 2020

Modeling accurately the evolution and intervention strategies for the Covid-19 pandemic, that has now affected almost every country in the world, is a challenging problem. We present here an analysis of an extended Susceptible-Exposed-Infected-Recovered (SEIR) model, that takes into account the presence of aymptomatic carriers, and explore the effects of different intervention strategies such as social distancing (SD) and testing-quarantining (TQ). The two intervention strategies (SD and TQ) try to reduce the disease reproductive number ($R_0 > 1$) to a target value ($R_0^{\rm target} < 1 ),butindistinctways,whichweimplementinourmodelequations.Wefindthatforthesametargetvalue,), but in distinct ways, which we implement in our model equations. We find that for the same target value, ),butindistinctways,whichweimplementinourmodelequations.Wefindthatforthesametargetvalue,R_0^{\rm target} <1 $, TQ is more efficient in controlling the pandemic than lockdowns that only implement SD. However, for TQ to be effective, it has has to be based on contact tracing and the ratio of tests/per day to the number of new cases/per day has to be scaled with the mean...

The Required Confronting Approaches Efficacy and Time to Control Iranian COVID-19 Outbreak

Archives of Clinical Infectious Diseases, 2020

The ongoing devastating epidemic of coronavirus disease 2019 (COVID-19) in Iran and the evolving public health situation is very concerning. We have developed a deterministic epidemiological SEIR (Susceptible, Exposed, Infectious, Recovered) model to quantify the required time and efficacy to bring the COVID-19 outbreak under control in Iran. Our results showed that the efficacy of COVID-19 confronting strategies on Feb 29th and March 9th were at 0.5 and 0.7, respectively owing to the relative equivalence number of infected cases estimated by the model and national officially reported cases. Therefore, to control the COVID-19 outbreak in Iran we strongly recommend maintaining the effectiveness of interventions at 0.7 or more at least for the next 4-6 weeks. Because the COVID-19 declining statistics over the next few days or weeks do not mean the definitive control of the outbreak.

Evaluating the Effect of Macro-Level Health Policies on Novel Coronavirus (COVID-19) Epidemic Control in Iran

ACTA MEDICA IRANICA, 2021

This study aimed to evaluate the effect of macro-level health policies on COVID-19 outbreak control in Iran. This was a descriptive-analytical study of the applied time series performed on April 19, 2020. The effect of four macro-health interventions, including reducing overcrowding, social distancing, limitation of high-risk economic activities, and active case detection, was examined. The Vector autoregression (VAR) was used to investigate the effect of the interventions. The augmented Dickey-Fuller test (ADF) was used to ensure the time stability of the time series and the existence of a unit-root. To analyzing data and estimation VAR models, STATA software was used. P of less than 0.1 was considered significant. The increase in the number of cases with two days’ lag had a positive and significant effect on increasing the number of new cases of the COVID-19 (C=0.176, P=0.097). Adopting an overcrowding reduction policy with both 2-day lags (c=0.095, P=0.066) and 4-day lags (c=0.31...

A SEIRD Model for Control of COVID-19: Case of Azerbaijan

SHS Web of Conferences

Research background:The study uses the key parameters of the spread of the epidemic, dividing the population into several groupsS- susceptible,E- exposed,I- infectious,R- recovered,D- dead. It is found that the model behaves differently depending on theR₀indicator - the average number of people that one infected manages to infect. Measures to suppress the epidemic undertaken by Azerbaijan and their effectiveness have been considered.Purpose of the article:The aim of the article is to model the current dynamics of the disease for future forecasting. The model takes into account all the main parameters of the epidemic: the proportion of severe patients and the mortality rate depending on the age of the patients, the duration of the incubation period and the infectious phase of the disease; incomplete registration of infected people due to the high prevalence of asymptomatic disease and insufficient testing; possible measures to contain and suppress the epidemic and their impact onR₀.M...

Projection of the Epidemics Trend of COVID-19 in Qom, Iran: A Modeling Study

Archives of Clinical Infectious Diseases, 2022

Background: Coronavirus is one of the major pathogens of the human respiratory system and a major threat to the human health. Objectives: This modeling study aimed to project the epidemics trend of coronavirus disease 2019 (COVID-19) in Qom, Iran Methods: This study projected the COVID-19 outbreak in Qom using a modified susceptible-exposed-infectious-recovered (SEIR) compartmental model by the end of December 2020. The model was calibrated based on COVID-19 epidemic trend in Qom from 1 January to 11 July. The number of infected, hospitalized, and death cases were projected by 31 December. A Monte Carlo uncertainty analysis was applied to obtain 95% uncertainty interval (UI) around the estimates. Results: According to the results, the reduced contact rate and increased isolation rate were effective in reducing the size of the epidemic in all scenarios. By reducing the contact rate from eight to six, the number of new cases on the peak day, as well as the total number of cases admitted to the hospital by the end of the period (31 December), decreased. For example, in Scenario A, compared to Scenario E, with a decrease in contact rate from eight to six, the number of new cases on peak days decreased from 15,700 to 1,100. The largest decrease in the number of new cases on peak days was related to Scenario F with 270 cases. Also, the total number of cases decreased from 948,000 to 222,000 between the scenarios, and the largest decrease in this regard was related to Scenario F, with 188,000 cases. Conclusions: The parameters of contact rate and isolation rate can reduce the number of infected cases and prevent the outbreak, or at least delay the onset of the peak. This can help health policymakers and community leaders to upgrade their health care systems.

Impact of non-pharmaceutical interventions on the COVID-19 epidemic: A modelling study

SAGE Open Medicine

Objective: This study aimed to assess the impact of non-pharmaceutical interventions on the COVID-19 epidemic in Oman. Methods: Data were retrieved from published national surveillance data between 24 February and 30 June 2020. To show the impact of the Government introduced public health intervention early in the epidemic, we used a simple disease-transmission model equation of the 2019-n CoV epidemic. Results: From all confirmed cases, the rates of intensive care unit admission were 4.56% (1824). We estimated an R0 of 3.11 with no intervention would result in nearly the entire population of Oman being infected within 65 days. A reduction of the R0 to 1.51 provided an estimated 89,056 confirmed cases, with 167 deaths or 0.4% mortality by June 30 with a requirement of 4052 intensive care unit beds. The current scenario (24 February to 30 June 2020) indicates an R0 of 1.41, resulting in 40,070 confirmed COVID-19 cases, 176 deaths and 69% of confirmed cases recovered. Conclusion: In e...

Assessing the Efficiency of Different Control Strategies for the Coronavirus (COVID-19) Epidemic

arXiv: Populations and Evolution, 2020

The goal of this work is to analyse the effects of control policies for the coronavirus (COVID-19) epidemic in Brazil. This is done by considering an age-structured SEIR model with a quarantine class and two types of controls. The first one studies the sensitivity with regard to the parameters of the basic reproductive number R0 which is calculated by the next generation method. The second one evaluates different quarantine strategies by comparing their relative total number of deaths.

Analysis of Effectiveness of Quarantine Measures in Controlling COVID-19

2020

COVID-19 has created an interesting discourse among the people of the world particularly regarding preventive measures of infectious diseases. In this paper, the authors forecast the spread of the Coronavirus outbreak and study how the reduction of transmission rates influences its decline. The paper makes use of the SIR (Susceptible Infected Recovered) Model which is a deterministic model used in the field of epidemiology-based on differential equations derived from sections of the population. The Basic Reproduction Number (R o) represents the criticality of the epidemic in numeric terms. Forecasting an epidemic provides insights about the geographic spreading of the disease and the case incidences required to better inform intervention strategists about situations that may occur during the outbreak. Through this research paper, the authors wish to provide an insight into the impact of control measures on the pandemic. By drawing a comparison of three countries and their quarantine measures, observations on the decline of the outbreak are made. Authors intend to guide the intervention strategies of under-resourced countries like India and aid in the overall containment of the outbreak.