Formulation and Evaluation of Oral Disintegrating Tablets of Ondansetron Hydrochloride (original) (raw)
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Formulation and Evaluation of Oral Disintegrating Film of Atenolol
Asian Journal of Pharmaceutical and Clinical Research
Objective: The main objective of the study was to formulate the oral disintegrating films loaded with atenolol by solvent-casting method and to carry out its evaluation studies.Methods: The films were prepared using the film-forming hydrophilic polymer like hydroxypropyl methylcellulose (E-5) and super disintegrant like pectin in various proportions.The formulated oral films were characterized for Fourier transform infrared (FTIR) and morphological evaluations. Various physicochemical parameters such as weight variation, folding endurance, surface pH, in vitro disintegration, and in vitro dissolution studies were carried out.Results: FTIR studies revealed that there was no drug-polymer interaction. The morphological evaluation of films showed that all the films were homogenous and transparent. The folding endurance test ensured that the films had sufficient brittleness and by weight variation test, it was inferred that all the films were within the deviation. The surface pH study sh...
Development and Evaluation of Ondansetron Orally Disintegrating Tablets
British Journal of Pharmacy, 2018
Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweetener on the formulation. Direct compression method was employed for making orally disintegrating tablets. The formulated orally disintegrating tablets have rapid disintegration property for better patient compliance. Formulated tablets were evaluated for physical parameters along with wetting time, disintegration time, drug content and "in vitro" dissolution. In first approach it was found that batch F7 containing Crospovidone (Polyplasdone XL 10) 10 mg showed minimum disintegration time (i.e. approx. 7.00 seconds) with maximum drug release. Wetting time for batch F7 was found to beminimum (i.e. 12 seconds). In second approach of selection of sweetener batch F 10 containing Sodium saccharin was found better in terms of Impurity study (Relative Substances study).Impurity was found within the specified limit compared to other two sweeteners. Stability study was carried out on optimized formulation. Overall batch containing 10 mg Crospovidone (Polyplasdone XL 10) along with Sodium Saccharin was foundstable both physically and chemically.
Development and in vitro evaluation of fast-dissolving oral films of ondansetron hydrochloride
2015
Ondansetron hydrochloride, a selective 5-HT3 receptor blocker, is an effective antiemetic drug with oral bioavailability of %60 and half-life of 4-5 h. The present study was carried out to prepare fast dissolving films of ondansetron hydrochloride to increase patient compliance and improve efficacy of drug. Films were prepared by solvent casting method, using poly vinyl alcohol, poly vinyl pyrrolidone and konjacglucomannan as film formers and PEG400 as plasticizer. Natural and synthetic sweeteners were used for masking bitterness of drug. Satisfactory results were obtained from evaluation of physical characteristics of fast dissolving films of ondansetron hydrochloride including: thickness: 37-39mm, surface pH: 6.77, folding endurance: up to 300 time and tensile strength: 35.75-50.93g/cm². Films were also subjected to an in vitro dissolution and release studies. In vitro drug release studies indicated 93-95% release in 5 min. Fast dissolving films of ondansetron could be a potentia...
Asian Journal of Applied Science and Technology (AJAST), 2021
Objective: The aim of this study was to develop a simple method for manufacturing oral dispersible tablets of ondansetron hydrochloride using direct compression method and to study the effect of different types and concentration of natural disintegrant (Isabgol mucilage, fenugreek mucilage and dehydrated banana powder) on the disintegrating characteristics of the tablets. Method: Disintegrants extracted from Isabgol, fenugreek and banana powder were used in formulation of tablet using placket burman design in minitab. Then 13 different formulations (F1- F13) were prepared varying the concentration of selected natural disintegrant (Isabgol mucilage extract 6-15%). Formulated tablets were investigated for weight variation, hardness, thickness, disintegration, drug content, friability. Result: The result obtained from disintegration study of tablets prepared using natural disintegrant obtained from isabgol mucilage indicates that the Isabgol with concentration 11.47% shows the disintegration time of 27 seconds. Conclusion: Orodispersible tablet of ondansetron hydrochloride was found to be effective with natural disintegrant obtained from isabgol mucilage
Orally disintegrating films: A modern expansion in drug delivery system
Saudi Pharmaceutical Journal, 2016
Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.
2018
DOI: 10.21276/sjmps.2018.4.1.1 Abstract: The purpose of present research work was to fabricate patient friendly, immediate release oral film of ondansetron hydrochloride using hydrophilic excipients. The film was prepared by solvent casting method. Hydroxyethyl cellulose, polyvinyl alcohol and polyvinylpyrrolidone k30 along with different plasticizers (peg 400 and pg) were scrutinized for film formulation. The auxiliary excipients used were sodium saccharin and sodium lauryl sulphate. The final selection was done with hydroxyethyl cellulose as a film former and peg 400 as a plasticizer for the film. The drug loaded films of hydroxyethyl cellulose were evaluated for thickness, uniformity in drug content, folding endurance, disintegration time, in-vitro drug release studies, tensile strength and drugexcipient compatibility studies. Taste masking was done by novel sandwich technology (placing the ondansetron hydrochloride film between two listerine pocket pack films). This approach can...
Membranes
The objective of the present study was to develop an orally disintegrating film (ODF) for a poorly water-soluble drug, phenytoin (PHT), using the cosolvent solubilization technique to achieve the amorphization of the drug, followed by the preparation of ODFs. Eleven formulations were prepared with different polymers, such as polyvinyl alcohol (PVA) and high methoxyl pectin (HMP) by the solvent casting method. The prepared films were subjected to characterization for weight variations, thickness, surface pH, disintegration time and mechanical strength properties. Then, differential scanning calorimetry, X-ray diffraction analysis and the drug release patterns of the selected films were evaluated. Among the prepared formulations, the formulation composed of 1% w/w of PVA, 0.04% w/w of sodium starch glycolate with polyethylene glycol 400, glycerin and water as cosolvents (PVA-S4) showed promising results. The physical appearance and mechanical strength properties were found to be good....
International Journal of Pharmacy and Pharmaceutical Sciences, 2019
Objective: The aim of the present study was to prepare the ondansetron hydrochloride Mouth Dissolving Tablets (MDTs) followed by its comparison with ethical and non-ethical (generic) marketed tablets. Methods: Prior to the formulation, drug excipient compatibility study was carried out by FTIR spectroscopy. The λmax was determined by UV spectroscopy. The ondansetron hydrochloride MDTs were prepared by direct compression method using Sodium Starch Glycolate (SSG) as super disintegrant and camphor as a sublimating agent. Then the prepared MDTs were subjected to evaluation of post compression parameters such as thickness and diameter, weight variation, wetting time, hardness, friability, disintegration and dissolution. The results obtained were compared with that of ethical and non-ethical marketed ondansetron hydrochloride 4 mg tablets. Results: The λmax was found at 310 nm. FTIR study revealed that excipients used in the prepared formulations are compatible with the drug. The thickne...
International Journal of Pharmaceutical Sciences and Drug Research, 2017
Mouth dissolving tablet is an innovative solid unit dosage form that overcome the problem of swallowing and provide rapid disintegration and dissolution to release the drug as soon as they come in contact with saliva, hence provide quick onset action. The aim of this study was to formulate and evaluate mouth dissolving tablets of Ondansetron hydrochloride using natural super disintegrating agent. Ondansetron hydrochloride is a serotonin receptor (5-HT3) antagonist used to treat nausea and vomiting arises during chemotherapy and radiation therapy. Mouth dissolving tablets were prepared by direct compression method using natural super disintegrating agent (Plantago ovata mucilage). Prepared tablet were evaluated for Hardness, weight variation, friability, thickness, wetting time, dispersion time, water absorption ratio, disintegration and dissolution study. According to results of optimized batches it has been concluded that Formulation batch F6 was an ideal batch which contain 12% w/...
Oral Disintegrating Tablets – A Current Review
The patient compliance lies in the ease with which the drug is delivered into the body without affecting its efficacy and without causing any inconvenience to the patient. For the patients who have a problem in swallowing, mainly the children and the old, oral disintegrating tablets (ODT) is a good choice. The products are designed to disintegrate or dissolve rapidly on contact with saliva, thus eliminating the need to chew the tablet, swallow an intact tablet, or take the tablet with liquids. Design of an ODT requires enough porosity inside the tablet for fast dissolving or fast melting while maintaining the mechanical strength of the tablet. Processing techniques such as freeze-drying, molding and sublimation, spray drying, direct compression followed by vacuum drying can be used to formulate ODTs. Formulation techniques such as incorporation of high levels of disintegrant, extragranular microparticulate active in conjunction with an effervescent agent, highly compressible excipients, aminoacid as a disintegrant, amorphous ingredient, hydrophilic waxy binder, combination of ion exchange resin and cyclodextrin, combination of the superdisintegrants and sublimation technique, specialized excipients such as effervescent couple and highly micronized agents. Various studies carried out by several scientists in the world are presented in this review article.