Enhancing Dissolution Rate of Carbamazepine via Solvent Casting with a Novel Polymeric Solubilizer (Soluplus ® ) (original) (raw)

Abstract

Purpose: To increase dissolution rate of Carbamazepine (CBZ) by forming solid dispersions (SD) with a novel polymeric solubilizer (Soluplus ®) via solvent casting technique. This study also attempted to investigate the solid state within the SD and its potential in enhancing the dissolution rate of CBZ. Methods: SD of CBZ-Soluplus ® at different weight ratios (1:9, 1:4, 1:3, 3:7, 1:1) were prepared by solvent casting technique. The SD samples were dried in an oven at 50 C until the loss on drying is greater than 78%. The SD is then cooled at -20 C for 1 hour. The SDs were gently grounded in a mortar and the resulting granules were sieved and the 106-500 μm particle size fraction was obtained. The dissolution profile of CBZ was performed in a USP II dissolution apparatus (paddle method) with 900 mL of 0.1N HCl (adjusted to pH 1.2) at 100 rpm and 37 C 0.5 C. The solution was filtered and continuously pumped into a Shimadzu UV 160U spectrophotometer and the absorbance values were recor...

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