Synthesis and antibacterial activities of 5-subsituted-4-amino-1,2,4-triazole-3-thiols. (original) (raw)

In the current study, 5-subsituted-4-amino-1,2,4-triazole-3-thiols were prepared fro- m substituted benzoic acid thorough multi step reaction sequence by the cyclization of potassium 3-aroyl-odithiocarbazates obtain ed from hydrazides, in turn prepared form esters. Structure of synthesized compounds was elucidated by using spect- roscopic techniques i-e., UV-Visible, FT-IR, 1 H and 13 C NMR and mass spectrom- etry. Results obtained show that 4-amino-5- o-tolyl-4H-1,2,4-triazole-3-thiol, 4-ami- no-5-m-tolyl-4H-1,2,4-triazole-3-thiol and 4-amino-5-p-tolyl-4H-1,2,4-triazole-3- thiol showed antibacter-ial activity