Tuberculosis in the San Diego-Tijuana Border Region: Time for Bi-National Community-Based Solutions (original) (raw)

Panorama of Tuberculosis in Mexico Focusing on the Northern Border

2015

Tuberculosis is one of humanity’s oldest diseases and the one that has caused the most death and suffering. It also continues to be a huge threat given the rise in resistance to medications, its link with the human immunodeficiency virus (hiv-aidS), and, particularly in Mexico and other countries, a closer and closer link to diabetes mellitus (dM), given the role of certain social determinants of health, such as poverty, marginalization, alcoholism, and migration. This is a generally chronic systemic or localized infectious disease caused by Mycobacterium tuberculosis (MTb), transmittable by air (from person to person), traveling through the droplets that accompany usually untreated patients’ coughs or sneezes. It manifests itself mainly in the form of a cough with phlegm, at times with blood, weight loss, afternoon fevers, heavy night sweats, fatigue, and loss of appetite.1 In Mexico, cases are found in all 31 states and Mexico City’s Federal District, but along the border it prese...

Border Lookout: Enhancing Tuberculosis Control on the United States-Mexico Border

The American journal of tropical medicine and hygiene, 2015

We evaluated the use of federal public health intervention tools known as the Do Not Board and Border Lookout (BL) for detecting and referring infectious or potentially infectious land border travelers with tuberculosis (TB) back to treatment. We used data about the issuance of BL from April 2007 to September 2013 to examine demographics and TB laboratory results for persons on the list (N = 66) and time on the list before being located and achieving noninfectious status. The majority of case-patients were Hispanic and male, with a median age of 39 years. Most were citizens of the United States or Mexico, and 30.3% were undocumented migrants. One-fifth had multidrug-resistant TB. Nearly two-thirds of case-patients were located and treated as a result of being placed on the list. However, 25.8% of case patients, primarily undocumented migrants, remain lost to follow-up and remain on the list. For this highly mobile patient population, the use of this novel federal travel intervention...

Multidrug-Resistant Tuberculosis Among Patients in Baja California, Mexico, and Hispanic Patients in California

American Journal of Public Health, 2013

Tuberculosis (TB) is an important health concern along the 1950-mile international border shared by Mexico and the United States. The neighboring states of Baja California, Mexico, and California, United States, have TB incidence rates that far exceed those of their respective countries. In 2008, the incidence rate for TB in Baja California was 50.9 per 100 000, versus 17.1 per 100 000 nationally in Mexico. 1 In California, the incidence of TB that same year was 7.4 per 100 000, compared with 4.2 cases per 100 000 persons in the United States. 2 Multidrug-resistant tuberculosis (MDR-TB) is TB disease associated with Mycobacterium tuberculosis strains that are resistant to isoniazid and rifampin, the 2 most effective TB medications available. 3 MDR-TB is found in Mexico and California, and significantly increases treatment and societal costs of TB, with case fatality rates ranging from 12% in HIVnegative to 90% in HIV coinfected persons. 3 Although TB control efforts worldwide are starting to decrease TB incidence and mortality, 4,5 the emergence of MDR-TB is "threatening to destabilize global TB control," 6(p261) and could rapidly turn TB into an untreatable disease, even in high-income countries. 7 California had an average of 41 MDR-TB cases per year from 1994 to 2003-the highest incidence of MDR-TB in the United States. 8 More than 85% of the incident MDR-TB cases in California from 1993 to 2006 were among foreign-born individuals, 28% of whom were born in Mexico. 7 In Mexico, although some studies of MDR-TB prevalence in specific populations have been conducted, 9-12 there is no routine surveillance data on MDR-TB for comparison. California and Baja California share a strong migratory dynamic. Translocation and contact between inhabitants of both sides of the border are frequent, and familial and other social relations extend across the border. 13 This

Latent tuberculosis in migrants travelling through the northeast regions of Mexico

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Background: Latent tuberculosis infection (LTBI) affects nearly a quarter of the global population. Public health interventions aimed at interrupting tuberculosis transmission do not routinely include systematic screening of migrant populations for LTBI in Mexico, nor other high-income countries. However, early detection and treatment of LTBI in immigrant populations from high-burden countries are recommended by the World Health Organization. Objective: The objective of this study was to determine the proportion of migrants with LTBI in shelters in northeastern Mexico. Methods: In this cross-sectional study, blood samples were obtained from 455 migrants living in shelters in northeastern Mexico during January 2017 to October 2019. LTBI was diagnosed using the QuantiFERON®-TB Gold Plus test. Results: Most of the migrants evaluated in this study were from Honduras; ~86% were male; the average age was 29 ± 10 years. LTBI was identified in 18.4% of those from Central America. Migrants from El Salvador and Nicaragua were more likely to have LTBI than those from Honduras or Guatemala. Overweight or obese persons and older persons had a higher prevalence of LTBI. We detected no significant differences with respect to LTBI when the results were compared based on gender, education, or marital status. Conclusion: The LTBI rates amongst migrants from Central America recently screened in shelters in northeastern Mexico appears to be relatively low given recent estimates of LTBI prevalence in Mexico.

Tuberculosis Treatment Completion in a United States/Mexico Binational Context

Frontiers in Public Health

Background: Tuberculosis (TB) remains a salient public health issue along the U.S./ Mexico border. This study seeks to identify the social and structural factors, which are associated with TB disease burden in the binational geographic region. Identification of barriers of treatment completion provides the necessary framework for developing evidence-based interventions that are culturally relevant and context specific for the U.S./Mexico border region. Methods: Retrospective study of data extracted from medical charts (n = 439) from Yuma County Health Department (YCHD) (n = 160) and Centro de Salud San Luis Río Colorado (n = 279). Patients currently accessing TB treatment at either facility were excluded from the study. Chi-square, unadjusted odds ratios, and logistic regression were utilized to identify characteristics associated with successful TB treatment in this population. Findings: The study population was predominantly male (n = 327). Females were more likely to complete TB treatment (OR = 3.71). The absence of drug use and/or the absence of an HIV positive diagnosis were found to be predictors of TB treatment completion across both clinical sites. Forty-four percent (43.59%) (n = 85) TB patients treated at CDS San Luis did not complete treatment versus 40.35% (n = 49) of TB patients who did not complete treatment at YCHD. Moving from the area or being deported was the highest category (20.78%) for incomplete TB treatment in the population (n = 64) across both clinical sites.

Latent Tuberculosis Infection in a Migrant Agricultural Community in Baja California, Mexico

Journal of Immigrant …, 2011

The objectives were to estimate the prevalence and identify correlates of latent tuberculosis infection (LTBI) among residents of a migrant agricultural community in San Quintín, Baja-California, Mexico. Residents completed a questionnaire and had their blood tested for LTBI using the QuantiFERON®-TB Gold In-Tube (QFT) assay. Among 133 participants, 39.8% (95% CI 31.5–48.7%) tested QFT-positive. Having crossed the U.S.-Mexican border since living in San Quintin (P = 0.03), consuming unpasteurized milk (P = 0.02) and receiving health care at IMSS-Oportunidades in the last 6 months (P = 0.03) were independently associated with QFT-positivity. High LTBI prevalence in this community emphasizes the need for TB education and LTBI treatment for its residents. Association with travel to the U.S. suggests the potential for TB transmission across borders. Higher QFT-positivity among those consuming unpasteurized milk could indicate M. bovis infection, previously reported among Mexican migrants living in U.S. border cities.