Age-stratified analysis of tumor markers and tumor characteristics in adolescents and young women with mature cystic teratoma (original) (raw)
Related papers
Gynecology Obstetrics & Reproductive Medicine, 2016
OBJECTIVE: We aimed to determine the diagnostic values of some clinical and ultrasonographic features for predicting ovarian malignancies in patients with normal serum CA-125 levels. STUDY DESIGN: All of the 84 patients who were diagnosed with ovarian malignancy and 168 patients with benign adnexal mass had normal CA-125 levels, and recruited as study and control groups, respectively. Individual characteristics, ultrasonographic features, and risk of malignancy index (RMI) values of the groups were compared retrospectively. RESULTS: The ages, mean postmenopausal period of the postmenopausal women in the malignant group were significantly higher than the benign group. Nulliparity rates were similar between the two groups. The number of postmenopausal patients was significantly higher in the malignant group. Median cyst diameter and RMI values were significantly higher, and bilaterality and presence of solid area were more frequent in this group. Logistic regression model showed that ovarian cysts larger than 8 cm [Odds ratio (OR): 7.012; p<0.001; 95% Confidence interval (CI): 3.463-14.198], presence of solid area within the cyst [OR: 7.43; p<0.001; 95% CI: 3.799-14.532], and postmenopausal state [OR: 2.893; p=0.027; 95% CI: 1.129-7.412] were found to be significant factors to predict malignancy. CONCLUSIONS: Ovarian cysts larger than 8 cm, presence of solid area within the cyst, and postmenopausal status are the most important risk factors for ovarian malignancies in these patients with normal CA-125 levels.
Elevated CA 125 level in a mucinous cystadenoma and a teratoma: a case report
Journal of Medical Case Reports
Background The presence of a suspicious ovarian cyst with elevated cancer antigen 125 level in a woman of reproductive age poses a serious therapeutic dilemma. Mature cystic teratomas and mucinous cystadenomas may also cause an increase in cancer antigen 125. Case presentation A 43-year-old Sinhalese woman with a history of anovulatory subfertility for 5 years presented with heavy menstrual bleeding and secondary dysmenorrhea of 6 months’ duration. Imaging (pelvic ultrasound and computed tomography of the abdomen and pelvis) revealed a hemorrhagic cyst (6 × 4 cm) on the right side and a multilocular cyst with solid areas (10 × 7 cm) on the left side. Her cancer antigen 125 level was 2715 U/ml. Following a multidisciplinary team meeting, a fertility-sparing staging laparotomy was performed, which included right cystectomy, left oophorectomy, infracolic omentectomy, and peritoneal washings. Histology revealed a mucinous cystadenoma of the right ovary and a mature cystic teratoma on th...
CA 125 levels in the preoperative assessment of advanced-stage uterine cancer
American Journal of Obstetrics and Gynecology, 2003
The purpose of this study was too evaluate preoperative levels of CA 125 in for the prediction of advanced uterine cancer. STUDY DESIGN: We conducted a retrospective analysis of the correlation of preoperative CA 125 with grade, depth of invasion, lymph vascular space involvement, lymph node status, and stage. RESULTS: High CA 125 levels correlated with advanced-stage (P < .0001) and positive (P < .0001) lymph node status. High levels of CA 125 also correlated with the deepest myometrial invasion, the presence of lymph vascular space involvement, and the highest grade. Receiver-operator characteristic curves demonstrated that depth of invasion, lymph vascular space involvement, and grade accurately predicted advancedstage disease 73%, 77% and 80% of the time, respectively. CA 125 levels, however, correctly predicted advanced stage 94% of the time. The sensitivity and specificity of a CA 125 cutoff level of 37 IU/mL were 95% and 90%, respectively, with a positive predictive value of 78% and a negative predictive value of 97%. CONCLUSION: CA 125 appears to be a significant independent predictor of positive lymph node status and the extrauterine spread of disease. (Am J Obstet Gynecol 2003;188:1195-7.)
Tumor markers in mature cystic teratomas of the ovary
Archives of Gynecology and Obstetrics, 2008
Objective The objective of this study was to evaluate the serum levels of tumor markers in patients with ovarian mature cystic teratomas. Method Retrospective study of 215 patients operated at Zekai Tahir Burak Women Health Education and Research Hospital between January 2001 and October 2006 was performed. Results The median age was 36 years (range 13-80). The mean tumor diameter was 7.7 § 4.6 cm (range 2-25). The mean serum CA 125 level was 26.2 § 29.9 U/mL (range 1.4-225, normal value <35), and the mean serum CA 19-9 level was 83.5 § 179.2 IU/mL (range 0.6-1,000; normal value <37). The elevated rate of CA 19-9, CA 125 was 39.6% (74/187) and 23.3% (50/215), respectively. The mean age of patients and the rate of bilaterality of tumors were similar in both patients with elevated CA19-9 and with normal CA 19-9 level (P > 0.05). The mean tumor size of patients with elevated CA 19-9 was greater than those with normal CA19-9 level (P = 0.01). Conclusion Serum CA 19-9 has the highest positivity rate among other tumor markers in ovarian mature cystic teratomas. Elevated serum CA 19-9 levels are correlated with larger tumor size. But the diagnostic value of elevated CA 19-9 in patients with MCT would be poor if the test was used alone.
Journal of Kathmandu Medical College, 2018
Introduction: Mature cystic teratoma of ovary, categorized as germ cell tumor is commonly seen in females of reproductive age group. The main aim of this study is to evaluate the serum level of CA 19-9 in those patients.Methods: A prospective study on 65 patients at First Affiliated Hospital, Guangxi Medical University, China within the period of one year. Patients underwent pelvic examination, ultra-sonograph and evaluation of serum level of CA 19-9, CA 125, CEA, AFP and SCCA prior to surgery. Following the surgery, samples were subjected for histo-pathological analysis where confirmatory diagnosis of Mature Cystic teratoma of ovary was established. Serum CA 19-9 was then re-analyzed following surgical removal of the tumor.Results: Mean age of patients with mature Cystic teratoma was 32.5±12.1 years (range 15-71). Mean tumor diameter was 5.8±2.4cm (range 2.3-12.2). Serum level of CA19-9 was the only tumor marker with a mean serum level (49.9±73.4IU/ml) above the cut-off value and i...
The role of tumor markers in predicting mature cystic teratoma of the ovary
2012
The objective of this study was to evaluate size, torsion rate, bilaterality, histopathologic origin, and the serum levels of some tumor markers in patients with mature cystic teratomas of the ovary. Methods. Retrospective study of 110 patients operated at Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Turkey, between January 1998 and December 2003 was performed. The patients were divided into two groups according to cut off levels of each cancer antigens (CA) 19-9 and CA 125. Statistical analysis of the data was performed by Student's t test, Pearson's chisquare test and Mann-Whitney rank sum test. Results. The mean age was 36.01 ± 12,403 years (range 15-78). The mean tumor diameter was 67.83±32.049 mm (range 27-211mm). The mean serum tumor markers of CA 19-9 and 125, carcinoembryogenic antigen and α-fetoprotein levels were 101.2±179.7 IU/mL, 32.0±37.8 U/mL, 1.46±1.20 ng/mL and 2.7±3.0 ng/mL. The bilaterally rate was 6.4% in the normal CA19-9 group and 5.4% in the normal CA125 group. There was no bilaterally in both of the elevated CA19-9 and CA125 groups. The histopathologic component of the teratomas were sebum (70%), hair (62.7%), keratin (20%), cartilage (16.3%) and teeth (3.6%). The torsion rate was 11.5% in the normal CA19-9 group, 15.20% in the normal CA125 group and 15.6% in the elevated CA19-9 group. There was no patient with torsion in the elevated CA125 group. Conclusion. Our study shows that there was no statistical significance between the two analyzed groups in respect to relation between tumor markers and the mean tumor size, bilaterally or torsion rate.
Collegium antropologicum, 2012
During the eighteen-year period in "Sestre milosrdnice" University Hospital Center, Zagreb, 271 women with ovarian tumor was studied. 229 women with ovarian cancer and 42 with borderline tumor. The pathohistological types of tumors were different. The age of the patients ranged from 20-83 years. In all patients the value of biochemical marker CA125 was determined. The aim of this study was to determine the usefulness of CA125 measurement in different age groups and in different patohistologycal forms of tumor. CA125 has proven to be positive in 89.1% of women with ovarian cancer and in 62% with neoplasm of low malignant potential. The higher values of CA125 were detected in younger women with low malignant tumor potential. Serous and metastatic tumor types were also associated with higher values of CA125.