Opioid receptors in human neuroblastoma SH-SY5Y cells: Evidence for distinct morphine (μ) and enkephalin (δ) binding sites (original) (raw)

This study investigates the binding characteristics of opioid receptors in human neuroblastoma SH-SY5Y cells, highlighting distinct binding sites for morphine (μ) and enkephalins (δ). The research demonstrates the saturability, stereospecificity, and reversibility of these receptors. The findings show the significance of guanine nucleotides and sodium chloride in regulating opioid binding, indicating distinct morphine and enkephalin interactions that could inform therapeutic strategies targeting opioid receptors.