Multiple Faces of Celiac Disease (original) (raw)
Celiac disease is also called as gluten-sensitive enteropathy and non-tropical sprue. It was first described by Dr. Samuel Gee in an 1888. The term "coeliac" was derived from Greek word koiliakaos-abdominal. The similar description by Aretaeus from Turkey reaches as far back as the second century AD. The cause of celiac disease was unexplained until 1950 when Dicke recognized an association between the consumption of bread, cereals and relapsing diarrhea. This observation was corroborated when, during periods of food shortage in the Second World War, the symptoms of patients improved once bread was replaced by unconventional, non-cereal containing foods like pure fruit, potatoes, banana, milk or meat. It is a chronic immune-mediated disorder of small intestine that occurs in genetically predisposed populations due to permanent intolerance to wheat gliadins and other cereal prolamins. They found that wheat, rye, barley and to a lesser degree oats, triggered malabsorption, which could be reversed after exclusion of the "toxic" cereals from the diet. Shortly after, the toxic agents were found to be present in gluten, the alcohol-soluble fraction of wheat protein. The epidemiology of CD has iceberg characteristics with more undiagnosed cases. The diagnosis of CD is currently based on both typical small bowel biopsy findings with clinical and serological parameters. The compliance rate regarding strict gluten restricted diet is variable and ranges from 50% to 90%. was Ninety (89.77%) and is more in females and in older age group in comparison to males and younger age group.
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