Biochemical Changes Induced in Liver and Serum of Aflatoxin B1-Treated Male Wistar Rats: Preventive Effect of Picroliv (original) (raw)

2001, Pharmacology and Toxicology

Administration of aflatoxin B 1 to rats (2 mg/kg intraperitoneally) caused significant increase in the activities of g-glutamyl transpeptidase, 5ø-nucleotidase, acid phosphatase, acid ribonuclease as well as content of lipid peroxides in liver after six weeks. However, the activities of succinate dehydrogenase, glucose-6-phosphatase, catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase and glutathione reductase in liver were decreased. The levels of glycogen and reduced glutathione were also decreased. There were significant elevations in the levels of serum transaminases, phosphatases (acid and alkaline), dehydrogenases (sorbitol, lactate and glutamate) and bilirubin following aflatoxin B 1 administration. Picroliv (25 mg/kg/day orally for six weeks), an iridoid glycoside isolated from the roots and rhizomes of Picrorhiza kurroa, significantly prevented the biochemical changes induced by aflatoxin B 1 .