Effects of Oral Administration of Non-genotoxic Hepato-hypertrophic Compounds on Metabolic Potency of Rat Liver (original) (raw)

Abstract

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This study investigates the effects of non-genotoxic hepato-hypertrophic compounds on the metabolic potency of rat liver, focusing on their influence on the genotoxicity of pro-mutagens. Orally administered compounds led to liver hypertrophy in rats, with significant changes observed in the mutagenicity of tested chemicals when using liver S9 derived from previously treated rats. Results indicate that these compounds may play a role in carcinogenesis by modulating the metabolism of pre-carcinogens, highlighting the complex interactions between environmental factors and metabolic pathways in the liver.

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