Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) bacteremia: series of 12 cases at Prince Sultan Military Medical City KSA (original) (raw)
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South Asian journal of cancer, 2013
Although Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) infections in immunocompromised hosts have been recognised, clinical data detailing these infections remain limited, especially from India. Antimicrobial susceptibility data on E. meningoseptica remain very limited, with no established breakpoints by Clinical and Laboratory Standards Institute (CLSI). The organism is usually multidrug resistant to antibiotics usually prescribed for treating Gram-negative bacterial infections, a serious challenge to the patient and the treating clinicians. The analysis was done in a tertiary care oncology and stem cell transplant center. Susceptibility testing and identification of E. meningoseptica was done using Vitek auto analyzer. Records of immunocompromised patients with E. meningoseptica bacteremia were analysed from January 2009 to March 2012. A total of 29 E. meningoseptica bacteremia cases were documented between 2009 and 2012. Eleven patients were immunocompromised....
Journal of Pure and Applied Microbiology
Elizabethkingia meningoseptica a rare pathogen in earlier times has been accused to infect the immunocompromised, preterm neonates, the patients exposed to longterm antibiotics and intensive care units. The apparent resistance of the multidrug Elizabethkingia meningoseptica affects the selection of appropriate antibacterial agents against it. The current study attempts to determine the prevalence of E. meningoseptica infections and consider the sensitivity pattern in a tertiary care hospital. A prospective study of prevalence of E. meningoseptica in a tertiary care hospital from March 2020 to March 2021 i.e over a period of 1 year. Patient clinical data as well as ABST patterns were collected and analyzed. Out of total 1813 patient’s samples E. meningoseptica was isolates from 21 cases (1.15%). Average age was 61.42 years, with males most likely to be infected (52.38%). All the adult patients had underlying diseases, obstructive gall bladder diseases (n=7, 33.33%) which included cho...
Intractable & Rare Diseases Research
Elizabethkingia species are gram negative bacilli which are aerobic, oxidase positive, indole positive, nonmotile bacilli and does not ferment glucose. They can be found commonly in freshwater, saltwater, soil and in hospital environments (1). They do not normally exists in the human body, but have been reported to cause various invasive infections like meningitis, pneumonia, endocarditis, and bacteremia in adults and neonates in association with severe underlying illness (2). The risk factors associated with acquisition of this infection include immunosuppression, underlying medical diseases, prolonged hospital stay, prior use of higher antibiotics, indwelling central venous catheter and other invasive devices (3). This organism is resistant to many antibiotics like beta-lactam antibiotics, aminoglycosides, tetracyclines, and chloramphenicol, However, it is susceptible to some agents used to treat Gram-positive bacteria like erythromycin, clindamycin, rifampicin, trimethoprim-sulfamethoxazole, quinolones and vancomycin (4). Selecting appropriate antimicrobial agents for patients infected with E. meningoseptica is difficult due to lack of data on clinical response to different treatments and also due to multiple drug resistance. In this report, we describe a series of four cases with E. meningoseptica bacteraemia and septic shock admitted to the ICUs of our level 1 Trauma Centre. 2. Patients and Methods This is a retrospective study conducted over a two Summary Elizabethkingia meningoseptica (E. meningoseptica) is a non-fermenting gram negative organism that is commonly detected in the soil and water but is rarely reported to cause human infection. However it is emerging as a nosocomial pathogen in patients admitted in intensive care units (ICUs). Infections caused by this organism have a high mortality rate due to lack of effective therapeutic regimens and its intrinsic resistance to multiple antibiotics. We report our experience in managing Elizabethkingia meningoseptica (E. meningoseptica) septicemia in our ICU patients with septic shock during prolonged intensive care management. Over a two year period four cases were admitted into the polytrauma ICU developed sepsis due to E. meningoseptica. All these patients were on mechanical ventilation, had central venous catheter (CVC) and were exposed to various broad spectrum antibiotics. Of the four patients, three died and one recovered. E. meningoseptica infection should be considered as a possible etiological agent of sepsis in patients who do not respond to empirical therapy, as this results in an inappropriate choice of antimicrobial therapy, leading to increased morbidity and mortality of patients. Its unusual resistance pattern along with inherent resistance to colistin makes this organism difficult to treat unless susceptibility patterns are available.
A Case Series of Elizabethkingia meningosepticum Bacteremia in the Cancer Population
Cureus, 2021
Elizabethkingia meningosepticum (E. meningosepticum) is a ubiquitous microorganism previously known as Chryseobacterium meningosepticum. It is emerging as a pathogen responsible for bacteremia in the immunocompromised population, particularly in cancer patients and those with a history of prolonged hospital stay and frequent instrumentations. A retrospective chart review of all cases over 10 years at the Moffitt Cancer Center showed a total of three patients with E. meningosepticum infection. The first patient (history of multiple myeloma) underwent endoscopy complicated by aspiration pneumonia and positive blood culture for E. meningosepticum infection. The second patient (current acute myelogenous leukemia) had neutropenic fever in the setting of a recent chest port infection. Blood culture from the chest port showed E. meningosepticum. The third patient (history of esophageal adenocarcinoma and acute myelogenous leukemia) had a history of recent pneumonia and cellulitis who presented with recurrent neutropenic fever. Blood culture was positive for E. meningosepticum. E. meningosepticum bacteremia has a high 28-day mortality rate (41%). As these three cases illustrate, early identification of the pathogen along with empiric treatment with a fluoroquinolone and/or minocycline is indicated to reduce morbidity and mortality.
International Journal of Advanced Research, 2020
Blood from a two day old male baby with history of respiratory distress and meconium aspiration was sent to the Department of Microbiology for culture. Blood culture yield non haemolytic small colonies of 1-2 mm on Blood agar and no growth on MacConkey agar.Based upon the colony characteristics, biochemical reactions, antimicrobial susceptibility pattern and identification by conventional and Vitek 2 Compact system, the isolate was identified as Elizabethkingia meningoseptica which is a rare cause of bacteremia in neonates.
Indian Journal of Medical Microbiology, 2013
the acquisition of this infection. [4,5] E. meningoseptica is an uncommon pathogen infrequently isolated from clinical specimens. Antimicrobial susceptibility data therefore is rather scarce regarding this rare pathogen. Moreover, results of susceptibility testing vary when different methods (viz. disc diffusion, microbroth dilution and E-test) are used. Even Clinical and Laboratory Standards Institute (CLSI) has no recommendations for performance and interpretation of antimicrobial susceptibility tests for this rare pathogen. [4-6] E. meningoseptica has a unique antibiogram and this pathogen though being a Gram-negative bacillus is inherently resistant to many antimicrobial agents commonly used to treat infections caused by Gram-negative bacteria (aminoglycosides, beta-lactam antibiotics, tetracyclines and chloramphenicol) but are often susceptible to agents generally used to treat infections caused by Gram-positive bacteria (rifampicin, clindamycin, erythromycin, trimethoprim-sulfamethoxazole, quinolones and vancomycin). This often leads to inappropriate choice of antibiotics for initial empirical therapy and results in treatment failures. [4-10] It is resistant to multiple antibiotics, especially beta-lactams as it produces two beta-lactamases viz. extended-spectrum beta-lactamase and a carbapenem hydrolyzing metallo beta-lactamase conferring resistance to many extended spectrum beta lactam antibiotics, aztreonam and carbapenems. However, various studies have found E. meningoseptica to be sensitive to piperacillin and piperacillin/tazobactam. [4-10] According to the results of the SENTRY antimicrobial surveillance program, the agents most active against E. meningoseptica are the quinolones, rifampin and trimethoprim-sulfamethoxazole while the susceptibility of the organism to aminoglycosides, beta-lactams, carbapenems and glycopeptides is low. [6]
A Retrospective Study on Elizabethkingia Meningoseptica -An Emerging Pathogen
Elizabethkingia meningoseptica is a ubiquitous Gram negative bacilli and is an emerging pathogen for hospital acquired infection.. The mortality rate is high and thus timely diagnosis is essential. Even more so because it is inherently resistant to a lot of antibiotics. In this retrospective study carried out over a period of 3 months at our tertiary care hospital, 12 patients were detected with Elizabethkingia meningoseptica predominantly from Endo-Tracheal tube aspirate.In 83.33% instances they caused nosocomial infection in COVID 19 patients.Mechanical ventilation, ECMO and prolonged exposure to carbapenems were significant risk factors associated with the infection. Cotrimoxazole was most sensitive among the antibiotics tested, followed by vancomycin and levofloxacin. Most of the other antibiotics active against Gram negative bacilli showed very high resistance including recent antibiotics like meropenem EDTA, ceftazidime-avibactam and ELORES (ceftriaxone+ sulbactum + EDTA). The outcome was not favourable in most cases