Letter to the editor regarding the article “Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis” (original) (raw)

This letter addresses the article by Atar et al. regarding the relationship between paraoxonase-1 (PON1) activity and polymorphisms in patients with urolithiasis. While commending the authors for their contribution to understanding stone formation mechanisms, several critical issues are raised, including the need to evaluate oxidant/antioxidant status, lipid metabolism profiling, and the assessment of metabolic disorders related to obesity. Furthermore, the lack of stone composition analysis is highlighted as a significant gap. The letter calls for further research to fully elucidate the implications of PON1 enzyme activities and polymorphisms in urinary stone formation.