Biopotentials of secondary metabolites isolated from marine sponges (original) (raw)
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Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Marine Sponges
docserv.uni-duesseldorf.de
Cytotoxic cyclic peptide……………………………………………………..….170 Biosynthesis of peptides………………………………………………………...171 Relationship between structures and cytotoxic activities of callyaerins …….....174 4.2. Metabolites isolated from the sponge Diacarnus megaspinorhabdosa…...…174 Cytotoxic norterpene peroxides…………………………………………………174 Proposed biosynthesis of terpene peroxides……………………..…………...…175 Mechanism of the antimalarial activity of cyclic peroxides…………………….177 Structure activity relationship of norterpene cyclic peroxides…………….……178 Indole, phenolic and nucleoside derivatives.………………………………...…179 Mechanism of action of nucleoside analogs.
Identification of Cytotoxicity of Marine Sponge Dendrilla Membranosa Against L929 Cell Line
International Journal of Scientific Research in Science and Technology, 2019
Marine sponges are rich sources of pharmacological active compound. Marine sponge, Dendrilla membranosa was collected from the Vizhingam coast. The sponge extract was tested against eight human bacterial pathogens. The bioactive compounds present in marine sponge were determined by GC-MS analysis. The cytotoxic effect of the sponge was evaluated by using MTT assay. The extracts showed potent anti-bacterial activity against Staphylococcus aureus, Bacillussubtilis, Streptococcus pyogens. The bioactive compound present in marine sponge was identified by GC-MS analysis and the compounds are ethane, butane, formate pentane, Alpha d-galactopyranoside, 2-Ethylhexyl2-ethylhexanoate, Hexahydro hexitol, Styrene, Alpha-d glucopyranoside 1-pentyl-2-proppyl-1-octene, nonadecane, 1,2-benzenedicarboxylic acid, bis-2, Octanoic acid. The test material showed none cytotoxic response to fibroblasts cells. The results of present investigation revealed that, Dendrilla membranosa is a potential source of novel anticancer and antibacterial leads.
Bioactive compounds from marine sponges
Several marine sponges from Okinawan waters have been examined for bioactive compounds. Further investigation with Polyfibrospongia sp. which have already yielded novel metabolites gave new hennoxazoles (6-9), of which 7 was moderately cytotoxic. Echinocluthn'a sp. furnished new pyridine alkaloids (1 0-1 2), two of which showed immunosuppressive activity. A sponge identified to be Dysidea herbacea afforded cytotoxic 20,24-dimethyldeoxoscalarin-3-one ( 1 4) along with known diterpenes. Two cytotoxic dimers (15,16) of a sesquiterpene have been isolated from Halichondria sp. Mytiloxanthin derivatives (1 8,19) were the major pigments of Phakellia stellidem. A new species of the family Niphatidae gave highly cytotoxic polyacetylenes (2 0-2 6).
Journal of the Marine Biological Association of India, 2016
A variety of biologically active compounds with unique structures and pharmacological properties have been reported to occur in marine organisms. Demospongiae, an important class of marine sponge is known for producing the largest number and diversity of secondary metabolites isolated till recent times. The review covers the diverse class of bioactive compounds isolated for therapeutic drug applications from different marine organisms. It is an attempt to update the marine research community with results of our ongoing search for bioactive secondary metabolites from marine sponge Spongosorites halichondriodes which has exhibited antibacterial, antifungal, cytotoxic, anti-inflammatory and immunomodulatory activity in our studies. Spongosorites halichondriodes (order Halichondrida, family Halichondriidae) is a predominant marine sponge collected from west coast of Mumbai, India. The sponge S. halichondriodes has shown presence of Octadecadienoic acid (Linoleic acid), ergostan tetraen-ol, dihydroxy cholanoic-methyl esters,C 28 saturated and unsaturated esters like 3β, 4β, 7α, 12α-tetrahydroxy-5β-cholan-24-oic acid methyl ester, 7α, 12β-dihydroxy-5β-cholan24-oic acid methyl ester, novel isocoumarin citrinolactone A, a triterpenoid glycyrrhetinic acid as well as other unknown compounds such as nucleoside inosine.
Screening and characterization of bioactive compound from Samalona island sponges, Indonesia
2015
Marine sponges contain unique chemical compounds that are potential to be developed as new drugs. This study aimed to screen and characterize bioactive compounds of sponges obtained from Samalona Island, South Sulawesi. The sponges were extracted with methanol and partitioned with chloroform-water mixture. The bioactivity of sponge extracts was tested against Artemia salina Leach. Extracts that showed high bioactivity/cytotoxicity were fractionated using vacuum liquid chromatography and isolated using preparative thin layer chromatography. The obtained isolates were then tested against A. Salina. The isolated compound with highest bioactivity was characterized using UV light (chemical reactions and spectrophotometer UV and IR. Three out of 15 sponges collected yielded a highly toxic extracts against A. salina and the most active chloroform extract was obtained from Penares sp. sponge. Fractionation and isolation of the Penares sp extract generated an isolate with high toxicity with ...
Bioactive Compounds from Marine Sponges: Fundamentals and Applications
Marine Drugs
Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from Theonella swinhoei have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have been identified from marine sponges that showcase the ability to act as antibacterial, antiviral, anti-malarial and antifungal agents against human pathogens and fish pathogens in the aquaculture industry. Moreover, the application of such compounds as antimicrobial agents in other veterinary commodities, such as poultry, cattle farming and domesticated cats, is discussed, along with a brief d...
The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp
Marine Drugs, 2022
A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl- 9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro- 3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2’-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. The stereoisomer of 3 was discovered in Ganoderma resinaceum, and metabolites 5 and 6, isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds 7 and 8 have not been found before in the genus Spongia. Compounds 1−9 were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities.
Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges
Revista Brasileira de Farmacognosia
Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity. This review remarks the attempt to provide a preliminary guidance from the perspective of structure-activity relationship and its participation on marine natural products research. This guidance is segregated by the compound's classes and their cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity. Structure-activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended to narrow down the endless possibilities of cytotoxicity by giving a predictable structure-activity relationship for active compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure-activity relationship with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge.