Working Memory Alterations After a Romantic Relationship Breakup (original) (raw)

2021, Frontiers in Behavioral Neuroscience

Experiencing stress can have a disadvantageous effect on mental well-being. Additional to the relation between suffering from chronic stress and depression, both stress (acute and chronic) and depression are associated with cognitive alterations, including working memory. The breakup of a relationship is considered to be a stressful event that can lead to symptoms of depression in otherwise healthy people. Additional to elevated depression scores, stress-related cognitive alterations may occur in this population as well. Therefore, in the present fMRI study we investigated whether experiencing a relationship breakup is associated with working memory alterations and whether this is related to depressive symptom severity. A three workload version of the n-back task (0-back, 1-back, 2-back) was used to measure working memory in subjects who experienced a breakup in the preceding 6 months (“heartbreak group”, n = 70) and subjects in a romantic relationship (“relationship group”, n = 46)...

Brain Activation During Emotional Memory Processing Associated with Subsequent Course of Depression

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015

Major depressive disorder (MDD) is characterized by a heterogeneous course and identifying patients at risk for an unfavorable course is difficult. Neuroimaging studies may identify brain predictors of clinical course and may help to further unravel the neurobiological processes underlying an unfavorable course. We investigated whether brain activation during an emotional memory paradigm is associated with depressive course. To this end, we followed 74 MDD-patients and 45 healthy controls (HC) for two years. At baseline, participants performed an emotional word-encoding and -recognition task during functional magnetic resonance imaging. Activation patterns were compared between patients with fast remission (n=22), remission with recurrence (n=23), non-remission (n=29) and HC. Additionally, linear relations of brain activation and time to remission during the follow-up period were investigated across patients. We observed that during encoding of negative words, non-remitters showed h...

Oh the lemons in life: Individual differences in emotion processing predict post-trauma depression

2016

The effect that trauma has on a person is variable—some individuals may develop depression, stress, or post-traumatic stress disorder, while others will cope more adaptively. A plethora of research has examined the negative effect of trauma on behavior and cognition. Yet less research has been conducted to elucidate what cognitive processes may underlie whether a person develops depression or is resilient after a stressful event. The goal of the present study is to investigate whether individual differences in emotion-processing in working memory may underlie the development of depression and stress (or not) in response to experiencing a recent trauma. Participants completed two experimental sessions. In the first session participants completed an emotion n-back task followed by questionnaires assessing depression, stress, and trauma history. In the second session 1 to 4 months later, participants again completed depression, stress, and trauma history questionnaires. Participants ...

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