Relationship between GnRH, Bradykinin and Inhibin/Activin (beta A and beta B subunits) and apoptosis in testes of infertile and aging men (original) (raw)

2004, Fertility and Sterility

correlations of adiponectin to the hormonal and metabolic parameters including measures of insulin resistance (IR). DESIGN: Case-control study. MATERIALS AND METHODS: One hundred and eighty selected women were classified as follows: 45 obese (BMI Ͻ30 kg/m 2) with PCOS; 45 lean (BMI Ͻ25 kg/m 2) with PCOS; 45 obese (BMI Ͼ30 kg/m 2) without PCOS and 45 lean (BMI Ͻ25 kg/m 2) without PCOS. Blood samples were collected from all women with or without PCOS between 8:00Ϫ11:00 a.m., after an overnight fast. Serum levels of LH, FSH, PROL, TSH, FT4, T, 17-OHP, ⌬4-A, DHEA, DHEAS, SHBG, insulin and plasma levels of adiponectin and glucose were determined. Measures of IR included: fasting serum insulin, GIR and HOMA. RESULTS: Adiponectin concentrations were found to be significantly decreased in women with PCOS and in obese without PCOS as compared to lean women without PCOS. Adiponectin concentrations correlated inversely with body weight, BMI, fasting plasma glucose, serum insulin, ⌬4-A, DHEA, DHEAS, HOMA, but correlated positively with serum T, SHBG, FAI and GIR. Multiple regression analysis showed that BMI, HOMA, ⌬4-A, and insulin were independent determinants of adiponectin concentrations. CONCLUSION: Hypoadiponectinaemia is evident in obese and lean women with PCOS with variable degree of IR; and it is suggested that IR per se and/or other metabolic abnormalities of PCOS are involved in the regulation of adiponectin concentration in women with PCOS.