Effect of Pore Size on Mechanical Integrity and Blood Flow in Polymeric Biomaterial via Computer Simulation Model (original) (raw)

2015

Abstract

Synthetic bio-materials are a substitute to diseased tissue. In ideal condition the fabricated tissue must mimic native tissue structurally as well as functionally. Millions are spent, however, little or no attention is paid to as how the fabricated material will behave under physiological conditions. We propose that a material must first be designed through software then it must be analysed for its mechanical properties and then it must go through prototyping and biocompatibility tests. Bone is a porous tissue with great variation in pore size and porosities. However, the effect of pore size on how the material will behave under mechanical forces and due to blood flowin vivo is poorly characterised. In this study we report the effect of pore size on the mechanical integrity and impact of blood flow of a synthetic polymer scaffold via computer simulation model. It was observed that increasing the pore size may significantly reduce implant success. It is suggested that anticipated si...

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