Circulating plasma VEGF response to exercise in sedentary and endurance-trained men (original) (raw)
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Pakistan BioMedical Journal
Endostatin and Vascular Endothelial Growth Factor (VEGF) are important markers driving the angiogenic switch. It is clear that short periods of moderate to high intensity exercise significantly increase the concentration of endostatin and VEGF in plasma. Objective: To investigate concentration of circulatory endostatin in plasma and impact of different intensities of exercise encompassing from low to maximum on distribution of endostatin and VEGF concentrations in plasma. Methods: Eight healthy male volunteers were recruited through advertisements and personal contacts, after assessing their fitness through two pre-participation health screening questionnaires, PAR-Q and ACSM Health Fitness Facility pre-participation health screening questionnaire for performing maximal exercise to volitional exhaustion. All the volunteers attend the lab on 2 consecutive days. The blood was centrifuged at 1000 RPM for 15 minutes for endostatin and VEGF and at 3000 RPM for 15 minutes for lipid profil...
Journal of Applied Physiology, 2005
VEGF-A contributes to muscle tissue angiogenesis following aerobic exercise training. The temporal response of the VEGF-A isoforms and their target receptors has not been comprehensively profiled in human skeletal muscle. We combined submaximal exercise with and without reduced leg blood flow to establish whether ischemia-induced metabolic stress was an important physiological stimuli responsible for regulating the VEGF-A system in humans. Nine healthy men performed two 45-min bouts of one-leg knee-extension exercise, with and without blood flow restriction. Muscle biopsies were obtained at rest and 2 and 6 h after exercise. Expression (mRNA) of the VEGF-A splice variants and related receptors [VEGF receptor (VEGFR)-1, VEGFR-2, and neuropilin-1] was determined by using qPCR. VEGF-Atotal expression increased more robustly after exercise with reduced blood flow, and initially this principally reflected an increase in VEGF-A165. Six hours after exercise, there was a relatively greater ...
Revista argentina de cardiología
background: The aim of this study was to assess the effect of acute and programmed physical exercise on plasma VEGF levels in chronic stable coronary artery disease patients. Following baseline evaluation, 21 patients <75 years underwent an exercise stress myocardial perfusion scan (acute), and were then randomly assigned to perform programmed rehabilitation exercise or continue with their normal therapy. VEGF assessed by SPECT imaging significantly decreased after stress ergometry (from 49.59±6.06 to 31.83±5.62 pg/ml; p=0.021). At one month, it increased (70.90±14.44 pg/ml) though not significantly with respect to baseline values (p=0.1) and significantly with respect to immediate post exercise values (p<0.01). No significant changes were observed in VEGF at 3 months or when results were compared according to the presence of ischemia or programmed exercise. Acute exercise induced a significant reduction in VEGF values, without differences between programmed exercise and the c...
2011
Selective breeding for high voluntary wheel running in untrained mice has resulted in a ‘mini muscle’ (MM) phenotype, which has increased skeletal muscle capillarity compared with muscles from non-selected control lines. Vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1) are essential mediators of skeletal muscle angiogenesis; thus, we hypothesized that untrained MM mice with elevated muscle capillarity would have higher basal VEGF expression and lower basal TSP-1 expression, and potentially an exaggerated VEGF response to acute exercise.We examined skeletalmuscle morphology and skeletalmuscle protein expression of VEGF and TSP-1 in male mice from two (untrained) mouse lines selectively bred for high exercise capacity (MM and Non-MM), as well as one non-selected control mouse line (normal aerobic capacity). In the MM mice, gastrocnemius (GA) and plantaris (PLT) muscle capillarity (i.e. capillary-to-fibre ratio and capillary density) were greater compared with control mice (P<0.05). In Non-MM mice, only muscle capillarity in PLT was greater than in controlmice (P <0.001). The soleus (SOL) showed no statistical differences inmuscle capillarity among groups. In the GA,MMmice had 58% greater basal VEGF (P <0.05), with no statistical difference in basal TSP-1 when compared with control mice. In the PLT, MM mice had a 79% increase in basal VEGF (P <0.05) and a 39% lower basal TSP-1 (P <0.05) compared with the control animals. Non-MMmice showed no difference in basal VEGF in either the GA or the PLT compared with control mice. In contrast, basal TSP-1 was elevated in the PLT, but not in the GA, of Non-MM mice compared with control mice. Neither VEGF nor TSP-1 was significantly different in SOL muscle among the three mouse lines. In response to acute exercise, MM mice displayed a 41 and 28% increase (P <0.05) in VEGF in the GA and PLT, respectively, whereas neither control nor Non-MM mice showed a significant VEGF response to acute exercise. In contrast, TSP-1 levels were decreased by 90% in GA (P <0.05) but increased by 50% in PLT (P <0.05) in response to acute exercise inMMmice. The SOL showed no response to exercise for either VEGF or TSP-1 for any of the mouse lines. These data, with the exception of the Non-MM plantaris muscle, suggest that elevated capillarity is associated with altered balance between positive and negative angiogenic regulators (i.e. VEGF versus TSP-1, respectively). Based on the greater capillarity and significant VEGF response to exercise in MM mice, these data suggest that VEGF expression may, at least in part, be genetically determined.
3 The Effect of Two Types of Physical Activity on Serum VEGF-A Response in Non-Athletic Men
2014
Corresponding Author : Tel : 09185403074, Email : m.baranchi@modares.ac.ir Sport Biosciences, Vol.6, No.1, Spring 2014 The aim of this study was to describe and examine the relationships in physical fitness, anthropometric and body composition profile male adolescent players of Iran national volleyball team. The sample of this study consisted of 40 players (Age: 17.9±0.3) present in the preparation camp of national adolescent volleyball team. Body composition factors (weight, BMI, WHR, body fat percentage, muscle mass) and anthropometric indexes (girths: waist, hip, abdomen, forearm, arm, thigh, calf; breadths: wrist, humerus, femur and lengths: stature, standing reach height, arm span, midstylion-dactylion, radiale-stylion, tibiale mediale, sphyrion tibiale) were measured. Also, physiological and physical fitness variables: heart rate, blood pressure, basal metabolic rate (BMR), long jump, bar fix, sit up, 20-m sprint, 4×9 m agility, spike jump, block jump, anaerobic power (15 s ...
URMIA MEDICAL JOURNAL
Background & Aims: It is more important to know which of physical activities could be the most effective way to cause angiogenesis. In this regards, we have investigated an 8-week aerobic training on vascular endothelial growth factor (VEGF) and Endostatin (ES) in sedentary women. Materials & Methods: 20 volunteer inactive women were chosen and were randomly divided in 2 groups of aerobic and control. Aerobic training programme consisted of 3 days per week for 8 weeks, each consists of 30 minutes with intensity of 65-70% of maximum heart rate was performed.. Before and after training, we have tested aerobic training and control group after an overnight fast. Blood Samples were used to conduct Enzyme-linked immunosorbent assay (ELISA). Independent and Dependent T-Test t were performed to see the significance level of (P<0.05. Results: Statistical analysis revealed that aerobic training increased VEGF and decreased ES to a significant level. Consequently, the results of Independent T Test revealed that there is an obvious difference (P<0.05), between the amount of VEGF and ES in control and intervention group. Conclusion:The results show that the equilibrium between angiogenesis and angiostatic agents. As a result, aerobic training is shifted toward angiogenesis factors. This result helps us to understand the process of angiogenesis consistence with aerobic training activities.
2016
Introduction: The present study aims to investigate the effect of one concurrent endurance and resistance exercise training session on plasma levels of vascular endothelial growth factor (VEGF) and endostatin in inactive women. Methods: In this quasi-experimental study, 12 inactive female university students were divided into control (average age=20.0 ±1.78 years, height = 161.3 ±50 cm, weight = 58.83±5.71 kg, BMI = 22.38±3.23 kg/m 2 ) and exercise (average age =19.5±1.04 years, height = 163.1±3.79 cm, weight = 58.67±7.69 kg, BMI =22.35±2.22 kg/m 2 ) groups. The endurance exercise was performed on a treadmill with 65% of MHR for 16 minutes. The resistance exercises of four movements including leg press, chest compression, armpit and leg stretch were performed at 50% 1RM in two sets with 10 repetitions and 1-2 minutes’ rest intervals between sets. Data were analyzed using dependent t-test and independent t-test to determine differences within the group and between-group at p<0.05....