Effect of Solvents on Spectrophotometric Estimation of Rizatriptan Benzoate (original) (raw)

Rizatriptan Benzoate is a selective 5-Hydroxy Tryptamine 1B/1D receptor agonist, which is used in the treatment of migraine headache. Three simple, sensitive, selective, accurate, precise, economical, robust, rapid and reproducible ultraviolet (UV) spectrophotometric methods have been developed and validated for quantitative estimation of Rizatriptan benzoate in bulk and tablet dosage form. The solutions of Rizatriptan were prepared using water and solvent blends containing acetonitrile: H2O (1:1), water: methanol (1:1) and studied their influence on estimation of Rizatriptan benzoate. The three different solutions of drug were scanned in the UV region of 200nm-400nm. Rizatriptan benzoate showed maximum absorbance at 224nm in all three different solvents, and obeyed Beer-Lambert's law in the concentration range of 2-12μg/ml. The linear regression equations were calculated to be Y=0.913x+0.0065 for acetonitrile: water (1:1) (R2 =0.9994), Y=0.0896x+0.0101 for methanol: water (1:1)...