To compare the efficacy of triple therapy with furazolidone, amoxicillin and omeprazole for two weeks and three weeks in the eradication of Helicobacter pylori in Bangladeshi duodenal ulcer patients (original) (raw)
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Bangladesh Medical Research Council Bulletin, 1970
Helicobacter pylori eradication is the mainstay in the treatment of Helicobacter pylori associated peptic ulcer disease. Furazolidone was tried in several developing countries and showed good results in some trials. Increasing the duration of treatment has been shown to improve the eradication rate. This study was done to compare the efficacy of triple therapy for two weeks (Group–A) and three weeks (Group–B) consisting of omeprazole 20 mg b.d. amoxicillin 1gm b.d. and furazolidone 200 mg b.d. in the eradication of Helicobacter pylori in duodenal ulcer patient. A total of 70 duodenal ulcer patients with Helicobacter pylori infection were included in the study. Healing of duodenal ulcer was assessed three months after the end of treatment and at the same time Helicobacter pylori eradication assessed by Campylobacter Like Organism (CLO) test and histology. In group–A, duodenal ulcer was healed in 17(58.62%) patients and Helicobacter pylori was eradicated in 15(52%) patients. In group-...
Medical science monitor : international medical journal of experimental and clinical research, 2002
The object of the study was to study the efficacy and safety of furazolidone and tetracycline compared to metronidazole and amoxicillin in an omeprazole based triple therapy in a prospective randomized-blind-clinical trial. Patients with endoscopically verified active duodenal ulcer disease in the presence of Helicobacter pylori infection were eligible to enter the study. Endoscopy was performed a day before and 6-8 weeks after the cessation of treatment. H. pylori status was assessed by histologic examination (Giemsa stain) of biopsy specimens were taken from the antrum and corpus. H. pylori eradication was defined as absence in histology of the biopsy specimens at the second endoscopy. Ulcer healing was considered as decrease in ulcer size to less than 20% of its primary size. Patients were randomly assigned to receive omeprazole 20 mg, amoxicillin 1000 mg and metronidazole 500 mg (OAM group) or omeprazole 20 mg, tetracycline 500 mg and furazolidone 200 mg (OTF group). All medicat...
2011
Background/aims: Furazolidone has been introduced as an effective drug against Helicobacter pylori infection in Iran, but intolerable side effects may limit its use. The aim of this study was to compare quadruple and triple furazolidone-based regimens to achieve an economically affordable regimen with acceptable success rate and fewer side effects. Methods: Patients with Helicobacter pylori positive peptic ulcer disease were randomly allocated into two groups: amoxicillin 1 g b.i.d., furazolidone 200 mg b.i.d. and omeprazole 20 mg b.i.d. with or without bismuth subcitrate 240 mg b.i.d. for two weeks (amoxicillin, furazolidone, omeprazole, bismuth and amoxicillin, furazolidone, omeprazole regimens, respectively). Helicobacter pylori eradication was confirmed by 13C-urea breath test 12 weeks after the end of therapy. Results:
Archives of Iranian medicine, 2007
Furazolidone has been effective against Helicobacter pylori in Iran, with no resistance, but with intolerable side effects in the second week. One-week regimens have not been useful here. We compared the efficacy and side effect profiles of three anti-H. pylori regimens. Patients with peptic ulcer disease and positive H. pylori infection were randomly allocated into three groups. The patients in group A received omeprazole 20 mg + amoxicillin 1g + metronidazole 500 mg, and bismuth subcitrate 240 mg twice daily each, for two weeks; the patients in group B received the same regimen but metronidazole was replaced by furazolidone 200 mg twice daily; and the patients in group C received regimen B for the first week and regimen A for the second week. H. pylori eradication was verified with 13C-urea breath test at the tenth week. Three hundred and fourteen patients were enrolled; 107, 104, and 103 patients in groups A-C, respectively but 278 patients completed the study. Seven, three, and ...
Journal of Chittagong Medical College Teachers' Association, 2016
Helicobacter pylori has an important association with Peptic Ulcer Disease (PUD). Numerous trials have proved that eradication of Helicobacter pylori results in healing of PUD and a very low recurrence rate. Attempts at eradication in Bangladesh with different regimens showed poor results. In Bangladesh there is no study with regimen containing Nitazoxanide and Omeprazole that showed to be very effective in several trails in different countries. This study was conducted in the Medicine department, Chittagong Medical College Hospital, from December 2008 to November 2009 to evaluate the efficacy of Nitazoxanide and Omeprazole in the eradication of Helicobacter pylori in PUD patients of Bangladesh. 130 endoscopically proven PUD patients were enrolled in this study when rapid urease test gave positive result & randomized into two halves for comparison of treatment regimens. After six weeks endoscopy was done. Ulcer healing, rapid urease test negativity and absence of Helicobacter pylori in histology was considered as cure. Conventional group treated with Clarithromycin, Amoxicillin, Lansoprazole for 14 days showed cure rate of 80%, whereas nitazoxanide group showed 76% cure, the difference is not statistically significant. This study shows that two regimens are effective and comparable though newer regimen failed to show superiority over conventional treatment.
Comparative Study Between Two Triple Therapy Regimens on Eradication of Helicobacter Pylori (HP)
2005
Helicobacter pylori (HP) are a bacterium that infects the mucus lining of the human stomach. HP has emerged as one of the most common bacterial pathogens worldwide [1] . It is estimated that about half the world’s population is infected with HP [2] . Curing the infection has the best outcome and is clearly the most cost effective management strategy for HP infected patients with ulcer disease [3] . The goal of the therapy is to eradicate the infection. A comparison of two ‘triple therapy’ regimen to patient with Rapid Urease Test (RUT) and histologically proven HP infection and to evaluation of cost factor of two regimens is studies Regimen-I Omeprazole 20mg bid-Clarithromycin 500mg bid –Amoxicilin 1g bid; Regimen-II Omeprazole 20mg bid-Clarithromycin 500mg bid – Tinidazole-500mg bid. It was hypothesized that Omeprazole – Clarithromycin – Amoxycillin regimen is superior to Omeprazole – Clarithromycin – Tinidazole regimen for eradication of HP. The study was conducted from in Kathman...