Pulsed Magnetic Field Induced Fast Drug Release from Magneto Liposomes via Ultrasound Generation (original) (raw)

Fast drug delivery is very important to utilize drug molecules that are short lived under physiological conditions. Techniques that can release model molecules under physiological conditions could play an important role to discover the pharmacokinetics of short lived substances in the body. Here an experimental method is developed for the fast release of the liposomes' payload without a significant increase in (local) temperatures. This goal is achieved by using short magnetic pulses to disrupt the lipid bilayer of liposomes loaded with magnetic nanoparticles. The drug release has been tested by two independent assays. The first assay relies on the AC impedance measurements of MgSO 4 released from the magnetic liposomes. The second standard release assay is based on the increase of the fluorescence signal from 5(6)-Carboxyfluorescein dye when it the dye is released from the magneto liposomes. The efficiency of drug release ranges from a few percent to up to 40% in case of the MgSO 4. The experiments also indicate that the magnetic nanoparticle generate ultrasound, which is assumed to have a role in the release of the model drugs from the magneto liposomes.