Synthesis of Adsorbents with Dendronic Structures for Protein Hydrophobic Interaction Chromatography (original) (raw)
Related papers
Synthesis of benzyl-terminated dendrons for use in high-resolution capillary gas chromatography
Tetrahedron Letters, 2001
The synthesis, silane functionalization, and facile silica attachment of dendritic monomers containing terminal benzyl groups are presented. For the first time, a simple one-step procedure is described that leads to the in situ creation of a surface-bonded sol-gel dendritic stationary phase on the inner walls of a fused silica capillary; such phases showed unique selectivities in high-resolution capillary gas chromatography.Graphic
Extractant impregnated resins for the recovery of aldehydes and chiral resolution
Science! true daughter of Old Time thou art! Who alterest all things with thy peering eyes. Why preyest thou thus upon the poet's heart, Vulture, whose wings are dull realities? How should he love thee? or how deem thee wise, Who wouldst not leave him in his wandering To seek for treasure in the jewelled skies, Albeit he soared with an undaunted wing? Hast thou not dragged Diana from her car? And driven the Hamadryad from the wood To seek a shelter in some happier star? Hast thou not torn the Naiad from her flood, The Elfin from the green grass, and from me The summer dream beneath the tamarind tree? My deepest gratitude goes to all the people who contributed to the research presented in the pages to follow: my scientific guides André de Haan and Louis van der Ham, my daily "shoulders for crying" Daleen Venter, Renze Wijntje and Željko Kotanjac, my students (Marko Zubić, Francisco Rodríguez Ropero, Marc Arderiu Girame, Gé Driessen), colleagues and dear friends from the former Separation Technology Group, my family. Thank you for lighting the flame inside me.
Dendronized polymers with tailored surface groups
Journal of Polymer Science Part A: Polymer Chemistry, 2005
A series of polymers tethered with bis-MPA dendrons was synthesized by a combination of divergent growth and atom transfer radical polymerization (ATRP). Macromonomers of first and second generation were synthesized utilizing the acetonide protected anhydride of bis-MPA as the generic esterfication agent. The macromonomers were polymerized in a controlled fashion by ATRP utilizing Cu(I)/Cu(II) and N-propyl-2-pyridylmethanamine as the halogen/ligand system. The end-groups of these polymers were further tailored to achieve hydroxyl, acetate, and aliphatic hexadecyl functionality. With this approach all polymers will emanate from the same backbone, enabling for an evaluation of both the generation and end-group dependent properties. Furthermore, a dendronized tri-block copolymer was synthesized. All materials were analyzed by 1 H and 13 C NMR, as well as size-exclusion chromatography (SEC). The SEC analysis revealed that the molecular weights of the divergently grown dendronized polymers increased with increasing generation while the polydispersity (PDI) was kept low. V
Bifunctional dendrons for multiple carbohydrate presentation via carbonyl chemistry
Beilstein journal of organic chemistry, 2014
The synthesis of new dendrons of the generations 0, 1 and 2 with a double bond at the focal point and a carbonyl group at the termini has been carried out. The carbonyl group has been exploited for the multivalent conjugation to a sample saccharide by reductive amination and alkoxyamine conjugation.
Over the past years, polymer-supported reagents have been extensively studied and used in various applications. One class of such reagents is called “scavengers,” which can be used to easily eliminate compounds in a solution. The present work describes the production of a resin that can be used for scavenging ketones and aldehydes using low-cost reagents and simple reaction steps, named here Amb15-Iso. This resin is obtained by reacting a low-cost commercial sulfonyl resin, Amberlyst-15, with isoniazid, a drug used for the treatment of tuberculosis. Acetone and isobutyraldehyde were used as carbonyl compound models. The reactions were monitored in-line by ATR-FTIR and results showed that the polarity of the solvent influences the kinetics of the production of the resin and water proved to be the fastest solvent. For the scavenging of acetone and isobutyraldehyde, two factors showed to have an impact in the amount of compounds captured: the polarity of the solvent and the solubility of water in the solvent. The capacity of scavenging acetone in water varied from 0.11 to 0.28 mmol per gram of resin, depending on the initial acetone concentration. The equilibrium of this reaction was modeled and the equilibrium constant was calculated to be 0.63 ± 0.07 L mol−1. The resin was also recycled and tested in a second round of scavenging and results showed that there was not much difference between the new resin and the recycled one, proving that the Amberlyst-15 could be reused for a second cycle of scavenging.